FlyBase Allele Report: Dmel\Doa[7]

General Information

Symbol

Dmel\Doa⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0002725

Feature type

allele

Associated gene

Dmel\Doa

Associated Insertion(s)

Carried in Construct

Also Known As

Doa¹⁰⁵

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Rabinow and Birchler, 1989)

Progenitor genotype

Caused by aberration

T(2;3)Doa¹⁰⁵

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sex-determination | female | recessive

(Du et al., 1998)

lethal | recessive

(Rabinow et al., 1993, Rabinow and Birchler, 1989)

visible (with Doa^01705b)

(Yun et al., 2000)

visible | adult stage (with Doa⁹)

(Kpebe and Rabinow, 2008)

visible | dominant

(Rabinow and Birchler, 1990)

Phenotype Manifest In

ommatidium (with Doa^01705b)

(Yun et al., 2000)

scutellar bristle | increased number (with Doa^01705b)

(Yun et al., 2000)

wing (with Doa⁹)

(Kpebe and Rabinow, 2008)

Detailed Description

Statement

Reference

The wings of Doa⁷/Doa⁹ mutant flies exhibit a held-out phenotype.

Doa⁷/Doa^E786 mutants exhibit defects in the mesothoracic tarsi.

Doa⁷/Doa³ mutants where the Doa⁷ allele is from the mother are viable. When the Doa³ allele comes from the mother there are no survivors.

In Doa⁷/Doa⁵ mutants where the Doa⁷ allele is from the mother only the males survive and they have held-out and fragile wings, ectopic crossveins, missing scutellar bristles. When the Doa⁵ allele comes from the mother there are no survivors.

In Doa⁷/Doa⁹ mutants where the Doa⁷ allele is from the mother it is predominantly males that are observed. These have rough eyes, held-out and fragile wings, duplication of the postalar bristles, missing scutellar or ocellar bristles, slight sexual transformations of females and disorganisation of the vaginal bristles. When the Doa⁹ allele comes from the mother there are no survivors.

In Doa⁷/Doa^E777 mutants where the Doa⁷ allele is from the mother only the males survive and the flies have held-out wings and duplication of the postalar bristles. When the Doa^E777 allele comes from the mother there are no survivors.

In Doa⁷/Doa⁰⁴⁷⁴³ mutants where the Doa⁷ allele is from the mother only males are observed. These have extremely rough eyes, ectopic wing veins, missing head, scutellar and thoracic bristles. When the Doa⁰⁴⁷⁴³ allele comes from the mother there are no survivors.

(Kpebe and Rabinow, 2008)

Transheterozygotes with Doa^01705b have rough eyes and duplicated scutellar bristles.

(Yun et al., 2000)

XX ; Doa⁷/Doa^Dem and XX ; Doa^unspecified/Doa⁷ adults have subtle intersexual characteristics.

(Du et al., 1998)

Heterozygotes with Doa^HD have ommatidia of varying size and disorganization of the interommatidial bristles. Random interruption of the normal lattice of pigment cells and random vacuolization of the retina and pigment cells are restored to at least normal levels (suppression of w^a).

(Yun et al., 1994)

Rare Doa^HD/Doa⁷ escapers of lethality are found at a frequency of approximately 0.5%.

(Rabinow and Birchler, 1989)

Heterozygotes with Doa^HD survive rarely and when they do, w^a is darkened to nearly wild-type color; w^sp55 reacts in the opposite manner, becoming nearly white; eyes of escapers have disarranged facets; both sexes involving Doa⁷ are weakly fertile.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Doa⁷/Doa^Dem, Srrm1^B103 has abnormal sex-determination phenotype

(Fan et al., 2014)

Doa⁷, E(gl)3C^unspecified has viable phenotype

(Yun et al., 2000)

Doa⁷, E(gl)3C^unspecified has fertile phenotype

(Yun et al., 2000)

Doa⁷, tra^unspecified has abnormal sex-determination | female phenotype

(Du et al., 1998)

Doa⁷, tra2^B has abnormal sex-determination | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra^unspecified has abnormal sex-determination | dominant | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra2^B has abnormal sex-determination | dominant | female phenotype

(Du et al., 1998)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Doa⁷/Doa^HD has phenotype, non-enhanceable by Ras85D^e2F

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-enhanceable by gl²

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-enhanceable by gl^60j

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-enhanceable by rl¹

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-enhanceable by rl^Sem

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-enhanceable by sina¹

(Yun et al., 2000)

NOT suppressed by

Statement

Reference

Doa⁷/Doa^HD has phenotype, non-suppressible by Ras85D^e2F

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-suppressible by gl²

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-suppressible by gl^60j

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-suppressible by rl¹

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-suppressible by rl^Sem

(Yun et al., 2000)

Doa⁷/Doa^HD has phenotype, non-suppressible by sina¹

(Yun et al., 2000)

Enhancer of

Statement

Reference

Doa⁷ is an enhancer of phenotype of w^sp55

(Rabinow and Birchler, 1989)

NOT Enhancer of

Statement

Reference

Doa⁷ is a non-enhancer of phenotype of w^a57i11

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^a58l

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^a2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^r

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^IR5

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^a3

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^sp81d

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^a59k1

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^sp2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^E

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^ec3

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^apl

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^IR2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^sat

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^bl

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^Bwx

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^a4

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^IR3

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^col

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^e2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^co

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of wⁱ

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^IR4

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^IR6

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^mo

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^IR1

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^h

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^bf2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^zm

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^bf

(Rabinow and Birchler, 1989)

Doa⁷ is a non-enhancer of phenotype of w^e

(Rabinow and Birchler, 1989)

Suppressor of

Statement

Reference

Doa⁷ is a suppressor of phenotype of w^aM

(Rabinow and Birchler, 1989)

Doa⁷ is a suppressor of phenotype of w^aR84h

(Rabinow and Birchler, 1989)

Doa⁷ is a suppressor of phenotype of w^a

(Rabinow and Birchler, 1989)

NOT Suppressor of

Statement

Reference

Doa⁷ is a non-suppressor of phenotype of w^a57i11

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^a58l

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^sp2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^ec3

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^IR2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^bl

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^E

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^col

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^e2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^IR4

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^IR6

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^mo

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^Bwx

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^a3

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^a4

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^apl

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^bf

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^IR3

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^bf2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^co

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^e

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^h

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of wⁱ

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^sat

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^zm

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^IR1

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^a2

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^r

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^IR5

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^sp81d

(Rabinow and Birchler, 1989)

Doa⁷ is a non-suppressor of phenotype of w^a59k1

(Rabinow and Birchler, 1989)

Other

Statement

Reference

Doa⁷, tra^unspecified has leg | female phenotype

(Du et al., 1998)

Doa⁷, tra2^B has leg | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra^unspecified has leg | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra2^B has leg | female phenotype

(Du et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

SRm160^B103 produces a female to male somatic sex transformation phenotype in Doa^HD/Doa⁷ mutant flies. The male genital arch and "claspers" are seen in XX individuals.

(Fan et al., 2014)

Doa⁷ in combination with E(gl)3C^unspecified results in flies with normal eyes, wings and bristles. No suppression of w^a is seen in these flies.

(Yun et al., 2000)

Heterozygous tra^unspecified/+ adults have normal sexual differentiation. XX ; tra^unspecified/+ adults that are also carrying Doa^unspecified/Doa⁷ are clearly intersexual with respect to the number or morphology of sex combs. Heterozygous tra2^B/+ adults have normal sexual differentiation. XX ; tra2^B/+ adults that are also carrying Doa^unspecified/Doa⁷ are clearly intersexual with respect to the number or morphology of sex combs.

(Du et al., 1998)

Rare Doa^HD/Doa⁷ escapers show extreme suppression of the w^a phenotype, such that eyes, Malpighian tubules, ocelli and testes are essentially wild-type in colour. They have disordered eye facets and scutellar bristles are often missing or abnormal. Male escapers carrying w^sp55 have bleach-white eyes.

(Rabinow and Birchler, 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99883

w^a; T(2;3)Doa¹⁰⁵, Doa⁷/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Doa¹⁰⁵

(Fan et al., 2014, Kpebe and Rabinow, 2008, Yun et al., 2000, Du et al., 1998, Yun et al., 1994, Rabinow et al., 1993, Rabinow and Birchler, 1990, Rabinow and Birchler, 1989)

Doa⁷

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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