FlyBase Allele Report: Dmel\w[sp55]

General Information

Symbol

Dmel\w^sp55

Species

D. melanogaster

Name

FlyBase ID

FBal0018306

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

mdg3{}w^sp55

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Zachar and Bingham, 1982)

Progenitor genotype

Associated Insertion(s)

mdg3{}w^sp55

Cytology

Description

Insertion of a mdg3 element into the 5' untranslated region.

(Bhadra et al., 1997)

mdg3 insertion into 5' untranslated leader sequence.

(Bhadra and Birchler, 1996)

mdg3 insertion in 5' untranslated leader.

(Larsson et al., 1996)

Insert stated as cause: undefined Insertion of a copia-like element.

(Soriano et al., 1995)

mdg3 insertion into the 5' untranslated leader of w.

(Birchler et al., 1994)

Parallel mdg3 insertion into 5' untranslated region.

(Csink et al., 1994)

Insert stated as cause: undefined Insertion of a retrotransposon near the transcription start site.

(Sabl and Birchler, 1993)

Insertion of an unknown transposon near the 5' start site of transcription.

(Birchler, 1992)

Transposable element near 5' structural gene.

(Rabinow et al., 1991)

Retrotransposon insertion.

(Birchler and Hiebert, 1989)

Insert stated as cause: undefined Retrotransposon insertion.

(Rabinow and Birchler, 1989)

Insertion of a 5.8kb transposable element within the w locus.

(Zachar and Bingham, 1982)

w⁺ mRNA not detected in this allele. w^sp55 enhanced by Doa (Rabinow and Birchler, 1989). 5.8 kb insertion map site (kb): +3 to +5; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Bhadra et al., 1997, Birchler et al., 1989)

abnormal eye color | recessive

(Frolov et al., 1998)

visible | recessive

Phenotype Manifest In

pigment cell

(Benevolenskaya et al., 1998, Frolov et al., 1998, Birchler et al., 1989, Rabinow and Birchler, 1989, Zachar and Bingham, 1982)

Detailed Description

Statement

Reference

eyes have lighter coloring.

(Csink et al., 1994)

Homozygous males are darker than homozygous females. Triple X metafemale individuals homozygous for w^sp55 exhibit a lighter eye colour than w^sp55 homozygous XX females.

(Birchler, 1992)

Eye colour: mottled with mw.

(Birchler et al., 1989)

Eye colour: almost bleach white in homozygous females.

(Rabinow and Birchler, 1989)

Eye colour: dark yellow in males; lighter in females.

(Zachar and Bingham, 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^sp55 has abnormal eye color phenotype, enhanceable by mw¹

(Birchler et al., 1989)

Suppressed by

Statement

Reference

w^sp55 has abnormal eye color | recessive phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^sp55 has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^sp55 has pigment cell phenotype, enhanceable by RpLP0⁰¹⁵⁴⁴

(Frolov and Birchler, 1998)

w^sp55 has phenotype, enhanceable by Mow^gamma

(Bhadra and Birchler, 1996)

w^sp55 has pigment cell phenotype, enhanceable by In(3)Msu¹/+

(Csink et al., 1994)

w^sp55 has pigment cell phenotype, enhanceable by In(3)Msu²/+

(Csink et al., 1994)

w^sp55 has phenotype, enhanceable by Ts(YSt;2Lt)B110+Ts(YSt;2Rt)R15

(Sabl and Birchler, 1993)

w^sp55 has phenotype, enhanceable by Ts(YLt;2Rt)G10+Ts(YLt;2Lt)R155

(Sabl and Birchler, 1993)

w^sp55 has phenotype, enhanceable by Ts(YSt;2Rt)L107+Ts(YSt;2Lt)P59

(Sabl and Birchler, 1993)

w^sp55 has phenotype, enhanceable by Ts(YLt;3Lt)A31+Ts(YLt;3Rt)G122

(Sabl and Birchler, 1993)

w^sp55 has phenotype, enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^sp55 has pigment cell phenotype, enhanceable by mw¹

(Birchler et al., 1989)

w^sp55 has phenotype, enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^sp55 has phenotype, enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^sp55 has phenotype, enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^sp55 has phenotype, enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^sp55 has phenotype, enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^sp55 has phenotype, enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^sp55 has phenotype, enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^sp55 has phenotype, enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

NOT Enhanced by

Statement

Reference

w^sp55 has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^sp55 has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^sp55 has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

w^sp55 has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^sp55 has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^sp55 has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^sp55 has phenotype, non-enhanceable by Ts(YLt;3Lt)B141+Ts(YLt;3Rt)G11

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Ts(YLt;3Lt)B116+Ts(YLt;3Rt)G48

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Ts(YSt;3Rt)G73+Ts(YSt;3Lt)R128

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Ts(YLt;2Rt)L52+Ts(YLt;2Lt)R15

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Ts(YSt;2Lt)H149+Ts(YSt;2Rt)R14

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Dp(2;Y)J64

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Ts(YSt;3Rt)A31+Ts(YSt;3Lt)D228

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Ts(YSt;3Lt)G48+Ts(YSt;3Rt)R36

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-enhanceable by Ts(YLt;3Rt)B21+Ts(YSt;3Lt)G11

(Sabl and Birchler, 1993)

Suppressed by

Statement

Reference

w^sp55 has pigment cell phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^sp55 has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

w^sp55 has phenotype, suppressible by Ufo¹

(Bhadra et al., 1997)

w^sp55 has phenotype, suppressible by Ts(YLt;2Rt)B110+Ts(YLt;2Lt)L138

(Sabl and Birchler, 1993)

w^sp55 has phenotype, suppressible by Ts(YLt;3Lt)B141

(Sabl and Birchler, 1993)

w^sp55 has phenotype, suppressible by Ts(YLt;3Lt)B21

(Sabl and Birchler, 1993)

w^sp55 has phenotype, suppressible by mw¹

NOT suppressed by

Statement

Reference

w^sp55 has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^sp55 has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^sp55 has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

w^sp55 has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^sp55 has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^sp55 has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

w^sp55 has phenotype, non-suppressible by Ts(YLt;2Rt)L52+Ts(YLt;2Lt)R15

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Ts(YSt;2Lt)H149+Ts(YSt;2Rt)R14

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Dp(2;Y)J64

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Ts(YSt;3Rt)A31+Ts(YSt;3Lt)D228

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Ts(YSt;3Lt)G48+Ts(YSt;3Rt)R36

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Ts(YLt;3Rt)B21+Ts(YSt;3Lt)G11

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Ts(YLt;3Lt)B141+Ts(YLt;3Rt)G11

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Ts(YLt;3Lt)B116+Ts(YLt;3Rt)G48

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by Ts(YSt;3Rt)G73+Ts(YSt;3Lt)R128

(Sabl and Birchler, 1993)

w^sp55 has phenotype, non-suppressible by east¹

(Chapman and Bingham, 1985)

Other

Statement

Reference

sgl⁰⁵⁰⁰⁷, w^sp55 has pigment cell phenotype

(Benevolenskaya et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Eye colour: lighter in Doa mutant males than w^sp55 Doa⁺. Eye colour: almost bleach white in homozygous females with Doa mutant. Eye colour: darker, with duplication for Doa⁺.

(Rabinow and Birchler, 1989)

Eye colour: mottled with mw.

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101233

w^sp55

Notes on Origin

Discoverer

Comments

Shows hyper-dosage compensation.

(Birchler, 1992)

Wow mutations dominantly cause a reduction of w pigmentation.

(Birchler et al., 1994)

The alkylating agents EMS, MMS, and ENU induce a clear increase in the frequency of somatic revertant sectors in the eye in w^sp55 flies.

(Soriano et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

w^sp55

wsp55

(Soriano et al., 1997)

Name Synonyms

spotted-55

(Rabinow and Birchler, 1989)

Secondary FlyBase IDs

References (22)

Report Sections

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