FlyBase Allele Report: Dmel\w[zm]

General Information

Symbol

Dmel\w^zm

Species

D. melanogaster

Name

zeste mottled

FlyBase ID

FBal0018326

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

3S18{}w^zm

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

spontaneous

(Peterson et al., 1994, Zachar and Bingham, 1982)

unequal recombination

Progenitor genotype

Associated Insertion(s)

3S18{}w^zm

Cytology

Description

Insertion of a 3S18 element into intron 1.

(Bhadra et al., 1997)

3S18 insertion in intron 1 at nucleotide position +3430.

(Larsson et al., 1996)

Insertion of a 3S18 element into the first intron of w.

(Judd, 1995)

3S18 insertion into intron 1.

(Csink et al., 1994)

6.4kb retrotransposon 3S18 insertion 11bp from the 5' end of the first intron at coordinate +3.43 (FBrf0041384) in the same transcriptional orientation as w, very near the site of w^a copia insertion.

(Peterson et al., 1994)

3S18 insertion.

(Birchler and Hiebert, 1989)

3S18 insertion.

(Rabinow and Birchler, 1989)

Fine structural analysis shows that the change in the w locus is located right of w^a and probably right of w^ch.

(Judd, 1965)

w^zm carries an insertion of the transposable element BEL near the 5' junction of the first intron at +3.5 (O'Hare, Murphy, Levis and Rubin, 1984). This insertion does not appear to alter the size of the 2.6 kb w⁺ transcript in w^zm and z w^zm flies (Levis, O'Hare and Rubin, 1984). 6.0kb BEL insertion map site (kb): +3.43; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:2,796,221..2,796,225 [-]

(Bhadra et al., 1997, Larsson et al., 1996, Davis and Judd, 1995, Judd, 1995, Peterson et al., 1994, Rabinow and Birchler, 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Birchler et al., 1989)

Phenotype Manifest In

pigment cell

(Birchler et al., 1989, Kalisch and Rasmuson, 1974)

Detailed Description

Statement

Reference

Eye colour: wild-type, in z⁺ males or females. Eye colour: red-brown mottled, in z¹ male. Eye colour: occasional red mottling, in z¹ female. Eye colour: lighter yellow background as z^v77h w^zl male, compared with z¹ w^zl male. Eye colour: darker yellow than z¹ as z^v77h w^zl female.

(Judd, 1995)

Repression of w^zm by z¹ is suppressed by Su(z)12¹.

(Birve and Rasmuson-Lestander, 1994)

No interaction with mutations of Rm62.

(Csink et al., 1994)

In homozygous z⁺ female w^zm causes variegation of the eye pigmentation.

(Kalisch and Rasmuson, 1974)

Eye colour: wild-type in z⁺ w^zm male and z⁺ w^zm/z⁺ w^zm female. Eye colour: lemon yellow, in z¹ w^zm female at 25^o-30^oC. Eye colour: orange with red spots, in z¹ w^zm female at 14^oC. Eye colour: lemon yellow with fine-grained red spots, in z¹ w^zm male at 25^oC-30^oC. Eye colour: almost wild-type, in z¹ w^zm male at 14^oC-17^oC. Eye colour: mottled, with mw.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^zm, z¹ has abnormal eye color phenotype, enhanceable by mw¹

(Birchler et al., 1989)

Other

Statement

Reference

w^zm, z¹ has abnormal eye color phenotype

(Birchler et al., 1989)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^zm has phenotype, enhanceable by Wow^γb

(Birchler et al., 1994)

w^zm has phenotype, enhanceable by Wow^γe

(Birchler et al., 1994)

w^zm has phenotype, enhanceable by Wow^ems1

(Birchler et al., 1994)

w^zm has phenotype, enhanceable by Wow^hd1

(Birchler et al., 1994)

w^zm, z¹ has pigment cell phenotype, enhanceable by mw¹

(Birchler et al., 1989)

NOT Enhanced by

Statement

Reference

w^zm has phenotype, non-enhanceable by Low¹

(Bhadra et al., 1997)

w^zm has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^zm has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^zm has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^zm has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^zm has phenotype, suppressible by E(z)⁶⁰

(Peterson et al., 1994)

NOT suppressed by

Statement

Reference

w^zm has phenotype, non-suppressible by Low¹

(Bhadra et al., 1997)

w^zm has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^zm has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^zm has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^zm has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

Other

Statement

Reference

w^zm, z¹ has pigment cell phenotype

(Birchler et al., 1989)

Additional Comments

Genetic Interactions

Statement

Reference

Eye colour: brown mottled in hemizygous z¹ w^zm male; z¹-like with occasional red mottling in homozygous z¹ w^zm female. Eye colour: wild-type, with dark flecks, in z¹ w^zm; E(z)⁶⁰ male.

(Peterson et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101256

y¹ z¹ w^zm sn³

Notes on Origin

Discoverer

Becker, 1959.

M.M. Green.

(Peterson et al., 1994)

Comments

Located to the right of w^a and to the left of w¹.

Unstable.

(Judd, 1969, Judd, 1957)

Unstable, mutating to derivatives, most of which are unstable.

(Judd, 1964, Judd, 1963)

Unstable; derivatives include w^zl (from the z¹ w^zm stock), w^zmz (from the z¹ w^zm stock) and w^zmzrb, w^zmzz and w^zmzw (from the z¹ w^zmz stock); only w^zl is stable; reverts to w^zm+ and z¹ w⁺) and the white-eyed w^zmzz and w^w; the derivatives were often recovered in clusters.

(Kalisch and Becker, 1970)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

w^zm

z^m

Name Synonyms

zeste mottled

(Judd, 1965)

zeste-mottled

(Rabinow and Birchler, 1989)

Secondary FlyBase IDs

References (28)

Report Sections

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