FlyBase Allele Report: Dmel\w[a3]

General Information

Symbol

Dmel\w^a3

Species

D. melanogaster

Name

apricot-3

FlyBase ID

FBal0018197

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Roseman et al., 1995)

Mutagen

spontaneous

(Zachar and Bingham, 1982, Dunn, 1935)

Progenitor genotype

Cytology

Description

Point mutation.

(Bhadra et al., 1997, Bhadra and Birchler, 1996, Roseman et al., 1995, Csink et al., 1994, Birchler and Hiebert, 1989, Rabinow and Birchler, 1989)

Point mutation in the structural portion of w.

(Rabinow et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002, Benevolenskaya et al., 2000, Bhadra et al., 1997, Peng and Mount, 1995)

abnormal eye color | recessive

(Frolov et al., 1998)

visible | recessive

Phenotype Manifest In

Malpighian tubule

pigment cell

(Lloyd et al., 2002, Benevolenskaya et al., 2000, Frolov et al., 1998, Peng and Mount, 1995, Zachar and Bingham, 1982)

Detailed Description

Statement

Reference

Homozygotes have reddy-orange eyes with only 28% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Eye colour: orange-brown.

(Zachar and Bingham, 1982)

Eye colour: orange; sexes similar. Malpighian tubule colour: colourless. Eye colour: like rb or g when w^a3 rb and w^a3 g.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^a3 has abnormal eye color phenotype, enhanceable by g^53d

(Lloyd et al., 2002)

w^a3 has abnormal eye color phenotype, enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

NOT Enhanced by

Statement

Reference

w^a3 has abnormal eye color phenotype, non-enhanceable by g²

(Lloyd et al., 2002)

w^a3 has abnormal eye color phenotype, non-enhanceable by g^50e

(Lloyd et al., 2002)

w^a3 has abnormal eye color phenotype, non-enhanceable by Rga⁰³⁸³⁴

(Frolov et al., 1998)

Suppressed by

Statement

Reference

w^a3 has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

NOT suppressed by

Statement

Reference

w^a3 has abnormal eye color phenotype, non-suppressible by Rga⁰³⁸³⁴

(Frolov et al., 1998)

NOT Enhancer of

Statement

Reference

w^a3 is a non-enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^a3 has pigment cell phenotype, enhanceable by g^53d

(Lloyd et al., 2002)

w^a3 has pigment cell phenotype, enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^a3 has phenotype, enhanceable by Ufo¹

(Bhadra et al., 1997)

NOT Enhanced by

Statement

Reference

w^a3 has pigment cell phenotype, non-enhanceable by g²

(Lloyd et al., 2002)

w^a3 has pigment cell phenotype, non-enhanceable by g^50e

(Lloyd et al., 2002)

w^a3 has phenotype, non-enhanceable by B52^ED

(Peng and Mount, 1995)

w^a3 has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^a3 has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^a3 has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^a3 has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

w^a3 has phenotype, suppressible by Mow^gamma

(Bhadra and Birchler, 1996)

w^a3 has phenotype, suppressible by Wow^γb

(Birchler et al., 1994)

w^a3 has phenotype, suppressible by Wow^γe

(Birchler et al., 1994)

w^a3 has phenotype, suppressible by Wow^ems1

(Birchler et al., 1994)

w^a3 has phenotype, suppressible by Wow^hd1

(Birchler et al., 1994)

w^a3 has phenotype, suppressible by Pcf11^γb

(Rabinow et al., 1991)

w^a3 has phenotype, suppressible by Pcf11^γc

(Rabinow et al., 1991)

w^a3 has phenotype, suppressible by Pcf11^γd

(Rabinow et al., 1991)

w^a3 has phenotype, suppressible by Pcf11^EMS3

(Rabinow et al., 1991)

w^a3 has phenotype, suppressible by Pcf11^EMS4

(Rabinow et al., 1991)

w^a3 has phenotype, suppressible by Pcf11^EMS5

(Rabinow et al., 1991)

w^a3 has phenotype, suppressible by Pcf11^hd1

(Rabinow et al., 1991)

NOT suppressed by

Statement

Reference

w^a3 has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

w^a3 has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

w^a3 has phenotype, non-suppressible by east¹

(Chapman and Bingham, 1985)

w^a3 has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

w^a3 has phenotype, non-suppressible by su(w^a)¹

NOT Enhancer of

Statement

Reference

w^a3 is a non-enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

w^a3, g^53d male mutants have lower amounts of pigment in the eye than w^a3 single mutants, although the effect is not strong enough to change the colour of the eye, as is the case for many other g^53d, w allele mutants. w^a3, g²/Y mutant flies have similar levels of red pigment in the eye to w^a3 single mutants and a slight decrease in red pigment compared to g² single mutants. Additionally, w^a3, g^50e/Y double mutant flies have similar levels of red pigment in the eye to g^50e single mutants.

(Lloyd et al., 2002)

The eye colour phenotype is not affected by Rga⁰³⁸³⁴.

(Frolov et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

151

w^a3

Kyoto

101216

w^a3

Notes on Origin

Discoverer

Curry, 2nd July 1934.

Comments

Dosage compensation is not affected by su(Hw)^V.

(Roseman et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

w^a3

Name Synonyms

apricot-3

Secondary FlyBase IDs

References (23)

Report Sections

Open Close