FB2024_03 , released June 25, 2024
Allele: Dmel\B52ED
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General Information
Symbol
Dmel\B52ED
Species
D. melanogaster
Name
Enhancer of Deformed
FlyBase ID
FBal0052459
Feature type
allele
Associated gene
Dmel\B52
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Mount and Peng, 1994)
Mutagen
ethyl methanesulfonate
(Kurkulos et al., 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: E70K. Conserved amino acid in the β4 strand of the first RNA-binding domain.

(Peng and Mount, 1995)

Amino acid replacement: E70K. Point mutation in the amino-terminal RNA binding domain.

(Mount and Peng, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:13,662,307..13,662,307 [+]
Nucleotide change:

G13662307A

Amino acid change:

E70K | B52-PA; E70K | B52-PB; E70K | B52-PC; E70K | B52-PD; E70K | B52-PF; E70K | B52-PI; E70K | B52-PK; E70K | B52-PM; E70K | B52-PN; E70K | B52-PO

Reported amino acid change:

E70K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Peng and Mount, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      B52ED is an enhancer of phenotype of wa

      (Peng and Mount, 1995, Mount and Peng, 1994, Kurkulos et al., 1991)

      B52ED is an enhancer of phenotype of wDR18

      (Peng and Mount, 1995, Mount and Peng, 1994)

      B52ED is an enhancer of phenotype of wbl

      (Peng and Mount, 1995)

      B52ED is an enhancer of phenotype of tra2B

      (Peng and Mount, 1995)

      B52ED is an enhancer of phenotype of wa4

      (Peng and Mount, 1995)

      B52ED is an enhancer of phenotype of tub4

      (Mount and Peng, 1994)

      B52ED is an enhancer of phenotype of waRE714

      (Kurkulos et al., 1991)
      NOT Enhancer of
      Statement
      Reference

      B52ED is a non-enhancer of phenotype of wa2

      (Peng and Mount, 1995)

      B52ED is a non-enhancer of phenotype of wa3

      (Peng and Mount, 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Transheterozygotes with Df(3R)ry27 produce very few adult progeny and those that survive have head defects that resemble those observed by in extreme Dfd mutants. This effect is due to an uncharacterised genetic element on the Df(3R)ry27 chromosome.

      (Peng and Mount, 1995)

      Transheterozygotes with wa have light eyes.

      (Kurkulos et al., 1991)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      X ray induced revertants are recovered, some are nulls. Null alleles are recessive lethal indicating that B52 is required for viability.

      (Mount and Peng, 1994)

      Mutation has no effect on the eye colour of wa2 or wa3.

      (Peng and Mount, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      B52ED
      E(Dfd)1
      (Mount and Peng, 1994)
      E726
      (Kurkulos et al., 1991)
      Name Synonyms
      Enhancer of Deformed
      (Peng and Mount, 1995)
      Secondary FlyBase IDs
      • FBal0021160
      References (7)