FlyBase Allele Report: Dmel\w[a2]

General Information

Symbol

Dmel\w^a2

Species

D. melanogaster

Name

apricot-2

FlyBase ID

FBal0018196

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Zachar and Bingham, 1982)

Progenitor genotype

Cytology

Description

Point mutation.

(Bhadra et al., 1997, Bhadra and Birchler, 1996, Larsson et al., 1996, Soriano et al., 1995, Csink et al., 1994, Birchler and Hiebert, 1989, Rabinow and Birchler, 1989)

Point mutation in the structural portion of w.

(Rabinow et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Xie and Birchler, 2012, Bhadra et al., 1997, Peng and Mount, 1995)

abnormal eye color | recessive

(Frolov et al., 1998)

visible | recessive

Phenotype Manifest In

eye

(Xie and Birchler, 2012)

Malpighian tubule

pigment cell

(Frolov et al., 1998, Peng and Mount, 1995, Zachar and Bingham, 1982)

Detailed Description

Statement

Reference

Fails to respond to E(w^a).

(Birchler and Hiebert, 1989)

Eye colour: orange-brown.

(Zachar and Bingham, 1982)

Eye colour: orange; darker in male. Malpighian tubule colour: colourless.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^a2 has abnormal eye color phenotype, enhanceable by Dp(2;2)Pdup-3/+

(Xie and Birchler, 2012)

Suppressed by

Statement

Reference

w^a2 has abnormal eye color phenotype, suppressible | partially by Df(2R)Pdel-1/+

(Xie and Birchler, 2012)

w^a2 has abnormal eye color phenotype, suppressible | partially by Pcf11^EMS2/Inr-a[+]

(Xie and Birchler, 2012)

w^a2 has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^a2 has eye phenotype, enhanceable by Dp(2;2)Pdup-3/+

(Xie and Birchler, 2012)

NOT Enhanced by

Statement

Reference

w^a2 has phenotype, non-enhanceable by Ufo¹

(Bhadra et al., 1997)

w^a2 has phenotype, non-enhanceable by B52^ED

(Peng and Mount, 1995)

w^a2 has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^a2 has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^a2 has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

w^a2 has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^a2 has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^a2 has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^a2 has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^a2 has eye phenotype, suppressible | partially by Df(2R)Pdel-1/+

(Xie and Birchler, 2012)

w^a2 has eye phenotype, suppressible | partially by Pcf11^EMS2/Inr-a[+]

(Xie and Birchler, 2012)

w^a2 has pigment cell phenotype, suppressible by RpLP0⁰¹⁵⁴⁴

(Frolov and Birchler, 1998)

w^a2 has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

w^a2 has phenotype, suppressible by Mow^gamma

(Bhadra and Birchler, 1996)

w^a2 has phenotype, suppressible by Wow^γb

(Birchler et al., 1994)

w^a2 has phenotype, suppressible by Wow^γe

(Birchler et al., 1994)

w^a2 has phenotype, suppressible by Wow^ems1

(Birchler et al., 1994)

w^a2 has phenotype, suppressible by Wow^hd1

(Birchler et al., 1994)

w^a2 has phenotype, suppressible by Pcf11^γb

(Rabinow et al., 1991)

w^a2 has phenotype, suppressible by Pcf11^γc

(Rabinow et al., 1991)

w^a2 has phenotype, suppressible by Pcf11^γd

(Rabinow et al., 1991)

w^a2 has phenotype, suppressible by Pcf11^EMS3

(Rabinow et al., 1991)

w^a2 has phenotype, suppressible by Pcf11^EMS4

(Rabinow et al., 1991)

w^a2 has phenotype, suppressible by Pcf11^EMS5

(Rabinow et al., 1991)

w^a2 has phenotype, suppressible by Pcf11^hd1

(Rabinow et al., 1991)

NOT suppressed by

Statement

Reference

w^a2 has phenotype, non-suppressible by Ufo¹

(Bhadra et al., 1997)

w^a2 has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^a2 has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^a2 has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

w^a2 has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^a2 has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^a2 has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

w^a2 has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

w^a2 has phenotype, non-suppressible by east¹

(Chapman and Bingham, 1985)

w^a2 has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Inr-a^EMS2/+ or Df(2R)Pdel-1/+ darkens the eye colour of w^a2 flies.

The addition of Dp(2;2)Pdup-3/+ lightens the eye colour of w^a2 flies.

(Xie and Birchler, 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (2)

Bloomington

150

w^a2

Kyoto

101215

w^a2

Notes on Origin

Discoverer

Bridges, 1929.

Comments

Shows no interaction with "Msu" mutations.

(Csink et al., 1994)

mle⁴ has no effect on the dosage compensation of w^e, w^apl, w^F4-2, w^a2, Dp(1;1)w⁺61e19 or wⁱ.

(Hiebert and Birchler, 1994)

The alkylating agent ENU at high concentration, but not MMS or EMS, induces a significant increase in the frequency of somatic revertant sectors in the eye in w^a2 flies.

(Soriano et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

w^a2

(Xie and Birchler, 2012)

wa2

(Soriano et al., 1997)

Name Synonyms

apricot-2

Secondary FlyBase IDs

References (25)

Report Sections

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