FlyBase Allele Report: Dmel\Pcf11[EMS2]

General Information

Symbol

Dmel\Pcf11^EMS2

Species

D. melanogaster

Name

FlyBase ID

FBal0029861

Feature type

allele

Associated gene

Dmel\Pcf11

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Rabinow et al., 1991)

Progenitor genotype

Cytology

Description

Coordinates are relative t the Inr-a-PD isoform.

(Xie and Birchler, 2012)

Nucleotide substitution: C?T.

(Xie and Birchler, 2012)

Amino acid replacement: R456term.

(Xie and Birchler, 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:14,867,661..14,867,661 [-]

Nucleotide change:

C14867661T

Reported nucleotide change:

C?T

Amino acid change:

Reported amino acid change:

R456term

(Xie and Birchler, 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Pal Bhadra et al., 1998)

lethal - all die before end of larval stage | recessive

(Rabinow et al., 1991)

non-suppressor of variegation, with In(1)w^m4h

(Bhadra et al., 1998)

some die during larval stage | recessive

(Rabinow et al., 1991)

Phenotype Manifest In

pigment cell

(Pal Bhadra et al., 1998)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pcf11^EMS2/Inr-a[+] is a suppressor | partially of abnormal eye color phenotype of w^a2

(Xie and Birchler, 2012)

Pcf11^EMS2/Inr-a[+] is a suppressor of abnormal eye color phenotype of w^a

(Xie and Birchler, 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Low¹/Pcf11^EMS2 is an enhancer of phenotype of w^sp1

(Bhadra et al., 1998)

Wow^unspecified, Mow^EMS, Pcf11^EMS2 is an enhancer of phenotype of w^sp1

(Bhadra et al., 1998)

Wow^unspecified, Mow^EMS, Low¹, Pcf11^EMS2 is an enhancer of phenotype of w^sp1

(Bhadra et al., 1998)

NOT Enhancer of

Statement

Reference

Pcf11^EMS2 is a non-enhancer of phenotype of w^sp1

(Bhadra et al., 1998)

Wow^unspecified/Pcf11^EMS2 is a non-enhancer of phenotype of w^sp1

(Bhadra et al., 1998)

Pcf11^EMS2 is a non-enhancer of phenotype of z¹

(Bhadra et al., 1998)

Wow^unspecified/Pcf11^EMS2 is a non-enhancer of phenotype of w^crr

(Bhadra et al., 1998)

Wow^unspecified, Low¹, Pcf11^EMS2 is a non-enhancer of phenotype of w^sp1

(Bhadra et al., 1998)

Mow^EMS, Low¹, Pcf11^EMS2 is a non-enhancer of phenotype of w^sp1

(Bhadra et al., 1998)

Suppressor of

Statement

Reference

Pcf11^EMS2/Inr-a[+] is a suppressor | partially of eye phenotype of w^a2

(Xie and Birchler, 2012)

Pcf11^EMS2/Inr-a[+] is a suppressor of eye phenotype of w^a

(Xie and Birchler, 2012)

Mow^EMS, Low¹, Pcf11^EMS2 is a suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Wow^unspecified, Mow^EMS, Pcf11^EMS2 is a suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Wow^unspecified, Mow^EMS, Low¹, Pcf11^EMS2 is a suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Mow^EMS/Pcf11^EMS2 is a suppressor of phenotype of w^sp1

(Bhadra et al., 1998)

Pcf11^EMS2 is a suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Mow^EMS/Pcf11^EMS2 is a suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Low¹/Pcf11^EMS2 is a suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Wow^unspecified, Low¹, Pcf11^EMS2 is a suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Pcf11^EMS2 is a suppressor of phenotype of w^a

(Pal Bhadra et al., 1998)

NOT Suppressor of

Statement

Reference

Wow^unspecified/Pcf11^EMS2 is a non-suppressor of phenotype of w^crr

(Bhadra et al., 1998)

Pcf11^EMS2 is a non-suppressor of phenotype of w^sp1

(Bhadra et al., 1998)

Wow^unspecified/Pcf11^EMS2 is a non-suppressor of phenotype of w^sp1

(Bhadra et al., 1998)

Wow^unspecified, Low¹, Pcf11^EMS2 is a non-suppressor of phenotype of w^sp1

(Bhadra et al., 1998)

Mow^EMS, Low¹, Pcf11^EMS2 is a non-suppressor of phenotype of w^sp1

(Bhadra et al., 1998)

Pcf11^EMS2 is a non-suppressor of phenotype of z¹

(Bhadra et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Inr-a^EMS2/+ darkens the eye colour of w^a and w^a2 flies.

(Xie and Birchler, 2012)

Inr-a^EMS2 mutants suppress mutant eye colour phenotype in w^crr mutants and has no effect on mutant eye colour phenotype in w^sp1 mutants. Inr-a^EMS2, Wow^unspecified mutants have no effect on mutant eye colour phenotype in w^crr or w^sp1 mutants. Inr-a^EMS2, Mow^EMS mutants suppress mutant eye colour phenotype in w^crr and w^sp1 mutants. Low¹, Inr-a^EMS2 mutants suppress mutant eye colour phenotype in w^crr mutants and enhance mutant eye colour phenotype in w^sp1 mutants. Low¹, Inr-a^EMS2, Wow^unspecified mutants suppress mutant eye colour phenotype in w^crr mutants and have no effect on mutant eye colour phenotype in w^sp1 mutants. Low¹, Inr-a^EMS2, Mow^EMS mutants suppress mutant eye colour phenotype in w^crr mutants and have no effect on mutant eye colour phenotype in w^sp1 mutants. Inr-a^EMS2, Wow^unspecified, Mow^EMS mutants suppress mutant eye colour phenotype in w^crr mutants and enhance mutant eye colour phenotype in w^sp1 mutants. Low¹, Inr-a^EMS2, Wow^unspecified, Mow^EMS mutants suppress mutant eye colour phenotype in w^crr mutants and enhance mutant eye colour phenotype in w^sp1 mutants. Inr-a^EMS2 increases the suppression of PEV caused by Wow^unspecified, Low¹.

(Bhadra et al., 1998)

The effect of Inr-a^EMS2 is epistatic to that of Wow^γb and Mow^EMS.

(Pal Bhadra et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Inr-a^EMS-2

(Xie and Birchler, 2012)

Inr-a^EMS2

Pcf11^EMS2

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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