FB2024_03 , released June 25, 2024
Allele: Dmel\tub4
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General Information
Symbol
Dmel\tub4
Species
D. melanogaster
Name
FlyBase ID
FBal0032951
Feature type
allele
Associated gene
Dmel\tub
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hecht and Anderson, 1993)
Progenitor genotype
Cytology
Description

Nucleotide change of T to A in the intron at its 5' end, in that region predicted to be recognised by the U1 small nuclear ribonucleoprotein.

(Letsou et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:4,388,398..4,388,398 [+]
Nucleotide change:

T4388398A

Reported nucleotide change:

T?A

Comment:

Nucleotide change of T to A in the intron at its 5' end, in that region predicted to be recognized by the U1 small nuclear ribonucleoprotein.

(Letsou et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tub4/tubR5.6 females produce embryos that are either moderately or strongly dorsalised.

      (Clemmons and Wasserman, 2013)

      Stronger dorsalising phenotype is seen at 18oC than 29oC. Transheterozygotes with tub4 are moderately dorsalised, the phenotype of tub2 Tl3t/tub1 is unchanged from the transheterozygote.

      (Hecht and Anderson, 1993)

      Homozygous pupae develop filzkorper and some ventral denticles.

      (Letsou et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      tub4 has phenotype, enhanceable by B52ED

      (Mount and Peng, 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Molecular alteration is predicted to reduce, but not eliminate, splicing.

      (Letsou et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tub4
      (Clemmons and Wasserman, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)