FB2024_03 , released June 25, 2024
Allele: Dmel\tubR5.6
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General Information
Symbol
Dmel\tubR5.6
Species
D. melanogaster
Name
FlyBase ID
FBal0035865
Feature type
allele
Associated gene
Dmel\tub
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Belvin et al., 1995, Hecht and Anderson, 1993, Letsou et al., 1993)

amorphic allele - molecular evidence

(Clemmons and Wasserman, 2013)
Mutagen
Delta2-3 transposase
(Hecht and Anderson, 1993)
Progenitor genotype
tub9
(Hecht and Anderson, 1993)
Cytology
Description

Imprecise excision of the P-element deleting 5kb of flanking DNA including the entire tub open reading frame.

(Hecht and Anderson, 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tubste/tubR5.6 and tub9Δ/tubR5.6 females produce embryos that span a phenotypic range from strongly dorsalised to wild type.

      tub2/tubR5.6 females produce embryos that are severely dorsalised.

      tub4/tubR5.6 females produce embryos that are either moderately or strongly dorsalised.

      tub7/tubR5.6 and tub8/tubR5.6 females produce embryos that span a phenotypic range from severely dorsalised to wild type.

      tub6/tubR5.6 and tub9/tubR5.6 females produce embryos that span a phenotypic range from severely to moderately dorsalised.

      (Clemmons and Wasserman, 2013)

      tubR5.6/Df(3R)XM3 larvae have significantly higher levels of muscle defects than wild-type larvae. Muscle fibre 8 is duplicated, and extra muscle fibres of undetermined identity in the neighbourhood of muscle fibres 4 and 5 are seen.

      (Halfon and Keshishian, 1998)

      Embryos exhibit a cuticular phenotype.

      (Yang and Steward, 1997)

      Injection of tor::tubt4021t construct and pll::tort4021p construct into tubR5.6/Df(3R)XM3 embryos induces dorsoventral pattern elements.

      (Großhans et al., 1994)

      Strongly dorsalised embryos, the phenotype of tubR5.6 Tl3t/tubR5.6 is also completely dorsalised.

      (Hecht and Anderson, 1993)

      Embryos derived from homozygous mothers gastrulate symmetrically and form hollow tubes of dorsalized larval cuticle. Homozygous pupae have a mean axial ratio of 2.5, whereas heterozygotes have a mean axial ratio of 3.0. Homozygotes carrying P{ptub462} have a mean axial ratio of 2.7.

      (Letsou et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tubR5.6 is rescued by tubptub462

      (Yang and Steward, 1997)
      Partially rescued by

      tubR5.6 is partially rescued by tubptubΔC205

      (Yang and Steward, 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      K. Anderson.

      (Letsou et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tubR5.6
      (Clemmons and Wasserman, 2013)
      tubr5.6
      (Halfon and Keshishian, 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (15)