FlyBase Allele Report: Dmel\g[53d]

General Information

Symbol

Dmel\g^53d

Species

D. melanogaster

Name

FlyBase ID

FBal0004981

Feature type

allele

Associated gene

Dmel\g

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Lindsley and Grell, 1968)

Progenitor genotype

Cytology

Description

No alteration in detected by Southern analysis.

(Lloyd et al., 1999)

Alleles separable by conversion; g^53d to the left of g².

(Lindsley and Zimm, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | male

(Lloyd et al., 2002)

abnormal eye color

(Cheli et al., 2010, Cheli et al., 2010, Lloyd et al., 2002, Lloyd et al., 1999)

abnormal eye color | recessive

(Warner et al., 1998, Simpson et al., 1997)

Phenotype Manifest In

eye

(Simpson et al., 1997)

Malpighian tubule

(Lloyd et al., 1999, Simpson et al., 1997)

pigment cell

(Lloyd et al., 2002, Lloyd et al., 1999, Lloyd et al., 1999, Warner et al., 1998)

pigment granule

(Simpson et al., 1997)

Detailed Description

Statement

Reference

Mutant flies have reduced red pigment in the eye compared to controls.

(Cheli et al., 2010, Cheli et al., 2010)

g^53d mutants have highly reduced levels of red and brown pigment in the eye compared to wild-type flies. g^53d mutant male flies show a greater degree of male-male courtship than wild-type flies.

(Lloyd et al., 2002)

Eyes of flies heterozygous for g^53d/Dp(1;f)LJ9 depend on parental derivation of Dp(1;f)LJ9 chromosome. Eyes show variegation if Dp(1;f)LJ9 derived from male parent, and not if Dp(1;f)LJ9 derived from female parent. The variegating phenotype persists for one generation only, i.e. is reset by passage through the germ line. The imprint is a response to the physiological sex of the parent, and does not depend on the particular allele of g opposite Dp(1;f)LJ9. Factors that affect position effect variegation influence the somatic expression but not the establishment of the imprinting.

(Lloyd et al., 1999)

Eye colour: flies show a fine-grained mottling of red spots on a pale background as they age. Eye colour: red pigments are reduced to 15 +/- 2% of wild-type levels, brown pigments are reduced to 13 +/- 2% of wild-type levels in females. Red pigments are reduced to 21 +/- 3% of wild-type levels, brown pigments are reduced to 7 +/- 4% of wild-type levels in males. Malpighian tubule colour: colourless (wild-type colour is orange). Testis colour: essentially wild type (wild-type colour is bright yellow).

(Lloyd et al., 1999)

Eye colour: pale orange. Malpighian tubule colour: colourless. Testis colour: wild-type. Ommatidia are well developed but pigment granules are absent.

(Simpson et al., 1997)

Lightly pigmented eyes and some pigment deposition in the ocelli.

(Tearle, 1991)

RK1.

(Lindsley and Grell, 1968)

Orange eyed.

(Hexter, 1963)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

g^53d has abnormal eye color phenotype, enhanceable by aux^UAS.cHa/Scer\GAL4^GMR.PF

(Cheli et al., 2010)

g^53d has abnormal eye color phenotype, enhanceable by z¹

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w^e(g)/w¹¹¹⁸

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w¹/w^e(g)

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w^Bwx/w^e(g)

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w^a/w^e(g)

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w^bf/w^e(g)

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w^co/w^e(g)

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w^sat/w^e(g)

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by z^a

(Lloyd et al., 2002)

g^53d has abnormal eye color phenotype, enhanceable by w^e(g)

(Lloyd et al., 2002)

g^53d/g^P has abnormal eye color phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g^53d/g[+], z¹ has abnormal eye color | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

g^53d/g^P has abnormal eye color phenotype, enhanceable by w^e(g)/w^e(g)

(Lloyd et al., 2002)

g^53d, z[+]/z¹ has abnormal eye color | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

g^53d, z¹ has abnormal eye color | male phenotype, enhanceable by E(z)¹

(Lloyd et al., 2002)

Suppressed by

Statement

Reference

g^53d has abnormal eye color phenotype, suppressible by w^HSBJ

(Lloyd et al., 2002)

Enhancer of

Statement

Reference

g^53d is an enhancer of abnormal eye color phenotype of w^a3

(Lloyd et al., 2002)

Other

Statement

Reference

g^53d, lt¹ has abnormal eye color | recessive phenotype

(Warner et al., 1998)

g^53d, lt¹/lt¹¹ has abnormal eye color | recessive phenotype

(Warner et al., 1998)

g^53d, lt¹¹ has abnormal eye color | recessive phenotype

(Warner et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

g^53d, z¹ has pigment cell phenotype, enhanceable | male by E(z)¹

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by z¹

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w^e(g)/w¹¹¹⁸

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w¹/w^e(g)

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w^Bwx/w^e(g)

(Lloyd et al., 2002)

g^53d/g^P has pigment cell phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w^a/w^e(g)

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w^bf/w^e(g)

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w^co/w^e(g)

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w^sat/w^e(g)

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by z^a

(Lloyd et al., 2002)

g^53d has pigment cell phenotype, enhanceable by w^e(g)/w^e(g)

(Lloyd et al., 2002)

g^53d/g[+], z¹ has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

g^53d/g^P has pigment cell phenotype, enhanceable by w^e(g)/w^e(g)

(Lloyd et al., 2002)

g^53d, z[+]/z¹ has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)¹

(Lloyd et al., 2002)

g^53d, z¹ has pigment cell | male phenotype, enhanceable by E(z)¹

(Lloyd et al., 2002)

Suppressed by

Statement

Reference

g^53d has pigment cell phenotype, suppressible by w^HSBJ

(Lloyd et al., 2002)

Enhancer of

Statement

Reference

g^53d is an enhancer of pigment cell phenotype of w^a3

(Lloyd et al., 2002)

Other

Statement

Reference

g^53d, lt¹ has pigment cell phenotype

(Warner et al., 1998)

g^53d, lt¹/lt¹¹ has pigment cell phenotype

(Warner et al., 1998)

g^53d, lt¹¹ has pigment cell phenotype

(Warner et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of aux^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF enhances the loss of red eye pigment that is seen in g^53d flies.

(Cheli et al., 2010)

w^e(g), g^53d double mutant flies have at least a 50% reduction of brown (ommochrome) pigments deposited in the eye compared to g^53d single mutants. There is also a reduction in red (pteridine) pigment to a lesser extent. All of the following w alleles when heterozygous with w^e(g) enhance the eye colour defective phenotype of g^53d mutants, leading to a greater reduction of red pigment within the eye: w¹¹¹⁸, w¹, w^a, w^bf, w^Bwx, w^co and w^sat. In contrast to g^53d homozygotes, g^P/g^53d transheterozygotes do interact with w^e(g), as g^P/g^53d, w^e(g) and g^P/g^53d, w^e(g)/+ flies have a reduced amount of red pigment in the eye compared to g^P, w^e(g) double mutant flies. The w^HSBJ transgene is able to increase the amount of red pigment in the eyes of g^53d mutant flies. The g^53d and following w alleles act additively to reduce eye pigmentation in double mutant male flies: w^a, w^a3, w^bf, w^ch, w^co, w^e, wⁱ and w^t. g^53d, z^a double mutants have a reduced amount of red pigment in the eye comparted to g^53d single mutants in both male and female flies. Likewise, g^53d, z¹ double mutant flies show decreased red eye pigment than g^53d mutants, although this reduction is greater in female flies than in male flies. Male E(z)¹/+, g^53d, z¹ triple mutants have less red pigment in the eye than g^53d, z¹ double mutants. Likewise, female E(z)¹/+, g^53d/+, z¹/+ triple mutants have a reduction in red eye pigment compared to g^53d/+, z¹/+ double mutants.

(Lloyd et al., 2002)

Eye colour: lt¹ g^53d double mutants show a marked reduction in eye pigment. Eye colour: lt¹/lt¹¹ g^53d double mutants show a reduction in red eye pigment compared to either lt¹/lt¹¹ or g^53d single mutants.

(Warner et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Hexter, April 1953.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

g^53d

(Cheli et al., 2010, Cheli et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (13)

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