FlyBase Allele Report: Dmel\g[P]

General Information

Symbol

Dmel\g^P

Species

D. melanogaster

Name

FlyBase ID

FBal0062819

Feature type

allele

Associated gene

Dmel\g

Associated Insertion(s)

P{}g^P

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lloyd et al., 2002)

Mutagen

P-element activity

(Ooi et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{}g^P

Cytology

Description

Insertion of a 2kb P-element 5' to the open reading frame, 21bp upstream of the most likely translation initiation site.

(Lloyd et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002, Lloyd et al., 1999)

abnormal eye color (with Df(1)HA92)

(Lloyd et al., 2002)

Phenotype Manifest In

pigment cell

(Lloyd et al., 2002, Lloyd et al., 1999)

pigment cell (with Df(1)HA92)

(Lloyd et al., 2002)

testis sheath

(Lloyd et al., 1999)

Detailed Description

Statement

Reference

Homozygotes have 50% red pigment in the eye compared to 100% in wild-type flies. Df(1)HA92/g^P flies have lower levels of red pigment in the eye than g^P homozygotes.

(Lloyd et al., 2002)

Eye colour: red pigments are reduced to 50 +/- 5% of wild-type levels in males. Testis colour: pale yellow (wild-type colour is bright yellow).

(Lloyd et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

g^53d/g^P has abnormal eye color phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g^53d/g^P has abnormal eye color phenotype, enhanceable by w^e(g)/w^e(g)

(Lloyd et al., 2002)

Df(1)HA92/g^P has abnormal eye color phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g^P has abnormal eye color phenotype, enhanceable by Df(1)N-8/+

(Lloyd et al., 2002)

g^P has abnormal eye color phenotype, enhanceable by Df(1)N-8/w^e(g)

(Lloyd et al., 2002)

NOT Enhanced by

Statement

Reference

g^P has abnormal eye color phenotype, non-enhanceable by w^e(g)

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

g^53d/g^P has pigment cell phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g^53d/g^P has pigment cell phenotype, enhanceable by w^e(g)/w^e(g)

(Lloyd et al., 2002)

Df(1)HA92/g^P has pigment cell phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g^P has pigment cell phenotype, enhanceable by Df(1)N-8/+

(Lloyd et al., 2002)

g^P has pigment cell phenotype, enhanceable by Df(1)N-8/w^e(g)

(Lloyd et al., 2002)

NOT Enhanced by

Statement

Reference

g^P has pigment cell phenotype, non-enhanceable by w^e(g)

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Unlike most g alleles, g^P, w^e(g) double mutants do not have reduced levels of red pigment in the eye compared to g^P single mutants. However, Df(1)HA92/g^P, w^e(g)/+ mutants do have lower levels of red pigment in the eye than Df(1)HA92/g^P single mutants. g^P, Df(1)N-8/+ double mutant flies have still less red pigment in their eyes than the Df(1)HA92/g^P, w^e(g)/+ mutants, while g^P, Df(1)N-8/w^e(g) flies have the least pigment of the mutant combinations described here. In contrast to g^53d homozygotes, g^P/g^53d transheterozygotes do interact with w^e(g), as g^P/g^53d, w^e(g) and g^P/g^53d, w^e(g)/+ flies have a reduced amount of red pigment in the eye compared to g^P, w^e(g) double mutant flies. g^P, Df(1)N-8/+ flies have less red pigment in their eyes than g^P single mutant flies; g², Df(1)N-8/w^e(g) flies have even less red pigment than g^P, Df(1)N-8/+ flies.

(Lloyd et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Unstable allele; reverts or mutates to a variety of more extreme phenotypes in 1-2% of progeny of dysgenic crosses.

(Lloyd et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

g^P

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close