FlyBase Allele Report: Dmel\w[sat]

General Information

Symbol

Dmel\w^sat

Species

D. melanogaster

Name

satsuma

FlyBase ID

FBal0018300

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Zachar and Bingham, 1982)

Progenitor genotype

Cytology

Description

Amino acid replacement: F590G. Mutation is at the C-terminal end of putative transmembrane spanning α-helix 5.

(Mackenzie et al., 1999)

Point mutation.

(Bhadra et al., 1997, Bhadra and Birchler, 1996, Birchler and Hiebert, 1989, Rabinow and Birchler, 1989)

Point mutation in the structural portion of w.

(Rabinow et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

MNV

X:2,791,023..2,791,025 [-]

Nucleotide change:

TTC2791025GGC

Reported nucleotide change:

TT5317GG

Amino acid change:

F590G | w-PA

Reported amino acid change:

F590G

Comment:

The reported Phe590 to Gly amino acid change (TTC to GGC) requires substitution at two positions in the codon.

(Mackenzie et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002, Mackenzie et al., 1999, Bhadra et al., 1997)

visible | recessive

Phenotype Manifest In

pigment cell

(Lloyd et al., 2002, Mackenzie et al., 1999, Zachar and Bingham, 1982)

Detailed Description

Statement

Reference

Homozygotes have brown-orange eyes with only 7% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Drosopterin (red pigment) levels are 4% of wild-type levels, xanthommatin levels (brown pigments) are 79% of wild-type levels.

(Mackenzie et al., 1999)

Eye colour: deep ruby.

(Zachar and Bingham, 1982)

Eye colour: deep ruby Malpighian tubule colour: nearly wild-type.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

w^sat has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Enhancer of

Statement

Reference

w^sat/w^e(g) is an enhancer of abnormal eye color phenotype of g^53d

(Lloyd et al., 2002)

w^sat/w^e(g) is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

NOT Enhancer of

Statement

Reference

w^sat/w^e(g) is a non-enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^sat has phenotype, enhanceable by Ufo¹

(Bhadra et al., 1997)

w^sat has phenotype, enhanceable by Wow^γb

(Birchler et al., 1994)

w^sat has phenotype, enhanceable by Wow^γe

(Birchler et al., 1994)

w^sat has phenotype, enhanceable by Wow^ems1

(Birchler et al., 1994)

w^sat has phenotype, enhanceable by Wow^hd1

(Birchler et al., 1994)

NOT Enhanced by

Statement

Reference

w^sat has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^sat has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^sat has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^sat has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^sat has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

w^sat has phenotype, suppressible by Mow^gamma

(Bhadra and Birchler, 1996)

w^sat has phenotype, suppressible by Pcf11^γb

(Rabinow et al., 1991)

w^sat has phenotype, suppressible by Pcf11^γc

(Rabinow et al., 1991)

w^sat has phenotype, suppressible by Pcf11^γd

(Rabinow et al., 1991)

w^sat has phenotype, suppressible by Pcf11^EMS3

(Rabinow et al., 1991)

w^sat has phenotype, suppressible by Pcf11^EMS4

(Rabinow et al., 1991)

w^sat has phenotype, suppressible by Pcf11^EMS5

(Rabinow et al., 1991)

w^sat has phenotype, suppressible by Pcf11^hd1

(Rabinow et al., 1991)

NOT suppressed by

Statement

Reference

w^sat has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^sat has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^sat has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^sat has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

w^sat/w^e(g) is an enhancer of pigment cell phenotype of g^53d

(Lloyd et al., 2002)

w^sat/w^e(g) is an enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

NOT Enhancer of

Statement

Reference

w^sat/w^e(g) is a non-enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Flies with a w^sat/w^e(g) mutant genotype enhance the eye colour defective phenotype of g² homozygous mutants leading to a greater reduction of red pigment in the eye. In contrast, w^sat/w^e(g), g^50e mutants have similar levels of red pigment in the eye to single g^50e mutants.