FlyBase Allele Report: Dmel\w[bf]

General Information

Symbol

Dmel\w^bf

Species

D. melanogaster

Name

buff

FlyBase ID

FBal0018215

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

roo{}w^bf

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lloyd et al., 2002, Roseman et al., 1995, Rabinow and Birchler, 1990)

Mutagen

spontaneous

(Rabinow et al., 1991, Collins et al., 1983)

Progenitor genotype

Associated Insertion(s)

roo{}w^bf

Cytology

Description

Insertion of a roo element into intron 4.

(Bhadra et al., 1997)

roo insertion in intron 4.

(Bhadra and Birchler, 1996)

roo insertion into intron 4.

(Larsson et al., 1996, Roseman et al., 1995, Csink et al., 1994, Rabinow and Birchler, 1989)

Insertion of a roo element.

(Soriano et al., 1995)

Two roo inserts separated by 30kb.

(Lim and Simmons, 1994)

roo element insertion in intron 4.

(Rabinow et al., 1991)

roo element insertion in the same orientation into the fourth intron.

(Rabinow and Birchler, 1990)

roo insertion in intron 4.

(Birchler and Hiebert, 1989)

Insertion of a 9.2 kb roo-element at map position -1.2 relative to the transcription start site of w.

(Collins et al., 1983)

roo insertion into the interval between coordinates -0.4 and -1.3, using coordinate system of FBrf0038648 where coordinate 0 is the copia insert of w^a.

(Zachar and Bingham, 1982)

w^bf is associated with an insertion of the transposable element roo (B104) at coordinate -1.13 on the molecular map of white within the intron between the third and fourth exons (Levis, O'Hare and Rubin, 1984; Zachar and Bingham, 1982). 8.7 kb roo insertion map site (kb): -1.13; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:2,791,675..2,791,679 [-]

(Bhadra et al., 1997, Bhadra et al., 1997, Bhadra and Birchler, 1996, Larsson et al., 1996, Roseman et al., 1995, Soriano et al., 1995, Lim and Simmons, 1994, Rabinow et al., 1991, Rabinow and Birchler, 1990, Rabinow and Birchler, 1989, Collins et al., 1983, Zachar and Bingham, 1982)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002, Bhadra et al., 1997, Birchler et al., 1989, Redfield, 1952)

visible | recessive

(Redfield, 1952)

Phenotype Manifest In

Malpighian tubule

(Redfield, 1952)

pigment cell

(Lloyd et al., 2002, Birchler et al., 1989, Redfield, 1952)

Detailed Description

Statement

Reference

Homozygotes have faint yellow eyes with only 2% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Eye colour: lighter than either mutation alone, with g¹. Eye colour: lighter than either mutation alone, with rb¹.

(Green, 1959)

Spontaneously reverts. Eye colour: light buff; somewhat lighter in males; lighter at 19^oC than at 25^oC. Malpighian tubule colour: colourless.

(Redfield, 1952)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^bf has abnormal eye color | recessive phenotype, enhanceable by Low¹

(Bhadra et al., 1997)

w^bf has abnormal eye color phenotype, enhanceable by mw¹

(Birchler et al., 1989)

Enhancer of

Statement

Reference

w^bf/w^e(g) is an enhancer of abnormal eye color phenotype of g^53d

(Lloyd et al., 2002)

w^bf/w^e(g) is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

w^bf/w^e(g) is an enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^bf has pigment cell phenotype, enhanceable by Low¹

(Bhadra et al., 1997)

w^bf has phenotype, enhanceable by mw²

(Rabinow and Birchler, 1990)

w^bf has pigment cell phenotype, enhanceable by mw¹

(Birchler et al., 1989)

NOT Enhanced by

Statement

Reference

w^bf has phenotype, non-enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^bf has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^bf has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^bf has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

w^bf has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^bf has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^bf has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^bf has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^bf has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^bf has phenotype, suppressible by Ufo¹

(Bhadra et al., 1997)

w^bf has phenotype, suppressible by Mow^gamma

(Bhadra and Birchler, 1996)

w^bf has phenotype, suppressible by Wow^γb

(Birchler et al., 1994)

w^bf has phenotype, suppressible by Wow^γe

(Birchler et al., 1994)

w^bf has phenotype, suppressible by Wow^ems1

(Birchler et al., 1994)

w^bf has phenotype, suppressible by Wow^hd1

(Birchler et al., 1994)

w^bf has pigment cell phenotype, suppressible by In(3)Msu¹/+

(Csink et al., 1994)

w^bf has pigment cell phenotype, suppressible by In(3)Msu²/+

(Csink et al., 1994)

w^bf has phenotype, suppressible by Su(w^a4)^M1

(Khatpova and Gerasimova, 1992)

w^bf has phenotype, suppressible by Pcf11^γb

(Rabinow et al., 1991)

w^bf has phenotype, suppressible by Pcf11^γc

(Rabinow et al., 1991)

w^bf has phenotype, suppressible by Pcf11^γd

(Rabinow et al., 1991)

w^bf has phenotype, suppressible by Pcf11^EMS3

(Rabinow et al., 1991)

w^bf has phenotype, suppressible by Pcf11^EMS4

(Rabinow et al., 1991)

w^bf has phenotype, suppressible by Pcf11^EMS5

(Rabinow et al., 1991)

w^bf has phenotype, suppressible by Pcf11^hd1

(Rabinow et al., 1991)

NOT suppressed by

Statement

Reference

w^bf has phenotype, non-suppressible by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^bf has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^bf has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

w^bf has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^bf has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^bf has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

w^bf has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^bf has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

w^bf has phenotype, non-suppressible by east¹

(Chapman and Bingham, 1985)

w^bf has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

w^bf/w^e(g) is an enhancer of pigment cell phenotype of g^53d

(Lloyd et al., 2002)

w^bf/w^e(g) is an enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

w^bf/w^e(g) is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

Other

Statement

Reference

In(3)Msu²/In(3)Msu¹, w^bf has pigment cell phenotype

(Csink et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Flies with a w^bf/w^e(g) mutant genotype enhance the eye colour defective phenotype of g², g^50e and g^53d homozygous mutants leading to a greater reduction of red pigment in the eye. Male w^bf, g^53d double mutant flies have lower levels of pigment in the eye than w^bf single mutants, leading to a change in eye colour from faint yellow to completely white.