FlyBase Allele Report: Dmel\w[Bwx]

General Information

Symbol

Dmel\w^Bwx

Species

D. melanogaster

Name

Brownex

FlyBase ID

FBal0018220

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Zachar and Bingham, 1982)

Progenitor genotype

Cytology

Description

Point mutation.

(Bhadra et al., 1997, Bhadra and Birchler, 1996, Csink et al., 1994, Birchler and Hiebert, 1989, Rabinow and Birchler, 1989)

3bp deletion, removing the ATC triplet encoding amino acid residue Ile581.

(Ewart et al., 1994)

Point mutation in the structural portion of w.

(Rabinow et al., 1991)

Deficiency from coordinate -18 to -14.5, using coordinate system of FBrf0038648 where coordinate 0 is the copia insert of w^a.

(Zachar and Bingham, 1982)

Restriction map of w^Bwx resembles that of Canton-S wild type except for a deletion of 150 bp (Zachar and Bingham, 1982).

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:2,791,050..2,791,052 [-]

Comment:

3bp deletion, removing the ATC triplet encoding amino acid residue Ile581.

(Ewart et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002, Benevolenskaya et al., 2000, Bhadra et al., 1997)

abnormal eye color | recessive

(Frolov et al., 1998)

abnormal eye color | semidominant

visible

(Ewart et al., 1994)

visible | semidominant

Phenotype Manifest In

Malpighian tubule

pigment cell

(Lloyd et al., 2002, Benevolenskaya et al., 2000, Frolov et al., 1998, Ewart et al., 1994, Zachar and Bingham, 1982)

testis pigment cell

Detailed Description

Statement

Reference

Homozygotes have dull red eyes with only 0.7% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Eye colour: brown.

(Ewart et al., 1994, Zachar and Bingham, 1982)

Eye colour: brown, like bw¹. Eye colour: duller and darker than wild-type as heterozygous female. Eye colour: brown, when heterozgous with other w alleles or w deletions. Eye colour: lighter than either single mutant as w^Bwx w^col. Eye colour: like w^a when heterozygous with w^a. Eye colour: like w^bf when heterozygous with w^bf. Testis colour: colourless. Malpighian tubule colour: pale yellow.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^Bwx has abnormal eye color phenotype, enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

Suppressed by

Statement

Reference

w^Bwx has abnormal eye color | recessive phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^Bwx has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Enhancer of

Statement

Reference

w^Bwx/w^e(g) is an enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

w^Bwx/w^e(g) is an enhancer of abnormal eye color phenotype of g^53d

(Lloyd et al., 2002)

w^Bwx/w^e(g) is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^Bwx has pigment cell phenotype, enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^Bwx has phenotype, enhanceable by Ufo¹

(Bhadra et al., 1997)

w^Bwx has phenotype, enhanceable by Wow^γb

(Birchler et al., 1994)

w^Bwx has phenotype, enhanceable by Wow^γe

(Birchler et al., 1994)

w^Bwx has phenotype, enhanceable by Wow^ems1

(Birchler et al., 1994)

w^Bwx has phenotype, enhanceable by Wow^hd1

(Birchler et al., 1994)

NOT Enhanced by

Statement

Reference

w^Bwx has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^Bwx has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^Bwx has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^Bwx has pigment cell phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^Bwx has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

w^Bwx has phenotype, suppressible by Mow^gamma

(Bhadra and Birchler, 1996)

w^Bwx has phenotype, suppressible by Pcf11^γb

(Rabinow et al., 1991)

w^Bwx has phenotype, suppressible by Pcf11^γc

(Rabinow et al., 1991)

w^Bwx has phenotype, suppressible by Pcf11^γd

(Rabinow et al., 1991)

w^Bwx has phenotype, suppressible by Pcf11^EMS3

(Rabinow et al., 1991)

w^Bwx has phenotype, suppressible by Pcf11^EMS4

(Rabinow et al., 1991)

w^Bwx has phenotype, suppressible by Pcf11^EMS5

(Rabinow et al., 1991)

w^Bwx has phenotype, suppressible by Pcf11^hd1

(Rabinow et al., 1991)

NOT suppressed by

Statement

Reference

w^Bwx has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

w^Bwx has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^Bwx has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

w^Bwx/w^e(g) is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

w^Bwx/w^e(g) is an enhancer of pigment cell phenotype of g^53d

(Lloyd et al., 2002)

w^Bwx/w^e(g) is an enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Flies with a w^Bwx/w^e(g) mutant genotype enhance the eye colour defective phenotype of g², g^50e and g^53d homozygous mutants leading to a greater reduction of red pigment in the eye.

(Lloyd et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type