FlyBase Allele Report: Dmel\w[IR1]

General Information

Symbol

Dmel\w^IR1

Species

D. melanogaster

Name

Inducer Reactive 1

FlyBase ID

FBal0018259

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

I{}w^IR1

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

IR-hybrid dysgenesis

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lajoinie et al., 1995)

Mutagen

IR-hybrid dysgenesis

(Milligan and Kaiser, 1993, Pelisson, 1981)

Progenitor genotype

Associated Insertion(s)

I{}w^IR1

Cytology

Description

Insertion of an I-element.

(Bhadra et al., 1997)

I-element insertion.

(Bhadra and Birchler, 1996, Rabinow and Birchler, 1989)

A full length I-element is inserted into the 5th intron at position -1448 (FBrf0041384). The transcriptional orientation of the I-element is opposite to that of the w locus.

(Lajoinie et al., 1995)

Insertion into non-translated region of the w gene.

(Vaury et al., 1995)

Antiparallel I-element insertion into intron 5.

(Csink et al., 1994)

Insertion of I-element.

(Abad et al., 1989)

I element insertion.

(Birchler and Hiebert, 1989)

An I-element maps either at the site of mutation or within less than 0.02 map units.

(Pelisson, 1981)

5.4kb I-element insertion map site (kb): -1.45; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Benevolenskaya et al., 2000, Bhadra et al., 1997, Pelisson, 1981)

abnormal eye color | recessive

(Frolov et al., 1998, Lajoinie et al., 1995)

visible | recessive

Phenotype Manifest In

pigment cell

(Benevolenskaya et al., 2000, Frolov et al., 1998, Lajoinie et al., 1995, Pelisson, 1981)

Detailed Description

Statement

Reference

Flies have red-brown eyes.

(Lajoinie et al., 1995)

Eye colour: brownish at 20^oC and a lighter colour at 25^oC.

(Pelisson, 1981)

Eye colour: brownish at 20^oC, lighter at 25^oC. Eye colour: z¹ w^IR1 males mottled orange eyes.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^IR1 has abnormal eye color phenotype, enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

Suppressed by

Statement

Reference

w^IR1 has abnormal eye color | recessive phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^IR1 has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^IR1 has pigment cell phenotype, enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^IR1 has phenotype, enhanceable by Mow^gamma

(Bhadra and Birchler, 1996)

w^IR1 has phenotype, enhanceable by Wow^γb

(Birchler et al., 1994)

w^IR1 has phenotype, enhanceable by Wow^γe

(Birchler et al., 1994)

w^IR1 has phenotype, enhanceable by Wow^ems1

(Birchler et al., 1994)

w^IR1 has phenotype, enhanceable by Wow^hd1

(Birchler et al., 1994)

w^IR1 has phenotype, enhanceable by Rm62^D

(Csink et al., 1994)

w^IR1 has phenotype, enhanceable by Rm62^Dem

(Csink et al., 1994)

w^IR1 has phenotype, enhanceable by Rm62^E

(Csink et al., 1994)

w^IR1 has phenotype, enhanceable by Rm62^F

(Csink et al., 1994)

w^IR1 has phenotype, enhanceable by Rm62^H

(Csink et al., 1994)

w^IR1 has phenotype, enhanceable by Rm62^K

(Csink et al., 1994)

NOT Enhanced by

Statement

Reference

w^IR1 has phenotype, non-enhanceable by Ufo¹

(Bhadra et al., 1997)

w^IR1 has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^IR1 has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^IR1 has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^IR1 has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^IR1 has pigment cell phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^IR1 has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

NOT suppressed by

Statement

Reference

w^IR1 has phenotype, non-suppressible by Ufo¹

(Bhadra et al., 1997)

w^IR1 has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^IR1 has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^IR1 has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^IR1 has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Pelisson.

Comments

Somewhat unstable under IR dysgenic conditions.

(Pelisson, 1981)

Used to test PCR amplification between gene-specific primers and I-element primers.

(Milligan and Kaiser, 1993)

The I-element insertion in w^IR1 interferes with the normal processing of w gene transcripts.

(Lajoinie et al., 1995)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

M14954

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

w^IR1

Name Synonyms

Inducer Reactive 1

Secondary FlyBase IDs

References (21)

Report Sections

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