FlyBase Allele Report: Dmel\Srrm1[B103]

General Information

Symbol

Dmel\Srrm1^B103

Species

D. melanogaster

Name

FlyBase ID

FBal0301138

Feature type

allele

Associated gene

Dmel\Srrm1

Associated Insertion(s)

P{?EP}Srrm1^B103

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Fan et al., 2014)

Mutagen

Delta2-3 transposase

(Fan et al., 2014)

Progenitor genotype

P{EP}Srrm1^GE25979

(Fan et al., 2014)

Associated Insertion(s)

P{?EP}Srrm1^B103

Cytology

Description

Imprecise excision of the P{EP} element in P{EP}SRm160^GE25979 has resulted in a 3653bp deletion, eliminating the entire coding region of SRm160 and parts of the non-coding region.

(Fan et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:13,037,011..13,040,663 [+]

Comment:

Inferred endpoints of a 3653 bp deletion resulting from the imprecise excision of P{EP}Srrm1^GE25979, which removes the Srrm1 gene.

(Fan et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Ustaoglu et al., 2019)

lethal | recessive

(Fan et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Srrm1^B103 is an enhancer of abnormal sex-determination phenotype of Doa^HD/Doa^Dem

(Fan et al., 2014)

Other

Statement

Reference

Doa⁷/Doa^Dem, Srrm1^B103 has abnormal sex-determination phenotype

(Fan et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

SRm160[+]/Srrm1^B103 is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, hid^UAS.cUa

(Fan et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

SRm160^B103 strongly enhances the female to male somatic sex transformation phenotype seen in Doa^HD/Doa^Dem mutant flies. The male genital arch and "claspers" are seen in XX individuals.

SRm160^B103 produces a female to male somatic sex transformation phenotype in Doa^HD/Doa⁷ mutant flies. The male genital arch and "claspers" are seen in XX individuals.

One copy of SRm160^B103 slightly suppresses the apoptosis seen in the eye when hid^Scer\UAS.cUa is expressed under the control of Scer\GAL4^GMR.PU.

(Fan et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Srrm1^GE25979

(Fan et al., 2014)

Srrm1^G18603

(Fan et al., 2014)

Fails to complement