FlyBase Allele Report: Dmel\w[e]

General Information

Symbol

Dmel\w^e

Species

D. melanogaster

Name

eosin

FlyBase ID

FBal0018237

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

pogo{}w^e

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lloyd et al., 2002, Roseman et al., 1995)

Mutagen

spontaneous

(O'Hare et al., 1991, Zachar and Bingham, 1982)

Progenitor genotype

w¹

(Frolov et al., 1998, Bhadra et al., 1997, O'Hare et al., 1991, Rabinow et al., 1991, Zachar and Bingham, 1982)

Associated Insertion(s)

pogo{}w^e

Cytology

Description

Insertion of a 190bp pogo element into the Doc element present in w¹.

(O'Hare et al., 1991)

w^e is derived from w¹ and carries an insertion of the transposable element pogo within the w¹ Doc insertion (O'Hare). 0.2kb pogo insertion in Doc element map site (kb): +3.71; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

X84406

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002, Benevolenskaya et al., 2000, Bhadra et al., 1997)

abnormal eye color | recessive

(Frolov et al., 1998)

visible | recessive

Phenotype Manifest In

Malpighian tubule

pigment cell

(Lloyd et al., 2002, Benevolenskaya et al., 2000, Frolov et al., 1998, Zachar and Bingham, 1982)

testis pigment cell

Detailed Description

Statement

Reference

Homozygotes have pink eyes with only 4% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Decrease in wild type eye pigment in the presence of Mow^gamma.

(Bhadra and Birchler, 1996)

Eye colour: homozygous males lighter than homozygous females. Triple X metafemale individuals homozygous for w^e have a darker eye colour than w^e homozygous XX females.

(Birchler, 1992)

Eye colour: light yellow-pink.

(Zachar and Bingham, 1982)

A w^e optic disk transplanted into a wild-type host shows autonomous eye color development.

(Beadle and Ephrussi, 1936)

Amount of pigment formed by w^e not a function of gene dose: w^e female = w^e male < w^e/w^e male = w^e/w^e female < w^e/w^e/w^e female.

(Muller, 1932)

Eye colour: females, yellowish-pink; males lighter than females. Eye colour: w^e/w¹ females, similar to w^e males. Testis colour: colourless. Malpighian tubule colour: colourless.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

w^e has abnormal eye color phenotype, non-enhanceable by Rga⁰³⁸³⁴

(Frolov et al., 1998)

Suppressed by

Statement

Reference

w^e has abnormal eye color phenotype, suppressible by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

NOT suppressed by

Statement

Reference

w^e has abnormal eye color phenotype, non-suppressible by Rga⁰³⁸³⁴

(Frolov et al., 1998)

Enhancer of

Statement

Reference

w^e/w^e(g) is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

w^e/w^e(g) is an enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^e has phenotype, enhanceable by Ts(YSt;2Lt)L23+Ts(YSt;2Rt)R155

(Sabl and Birchler, 1993)

w^e has phenotype, enhanceable by Ts(YLt;3Lt)A31+Ts(YLt;3Rt)G122

(Sabl and Birchler, 1993)

w^e has phenotype, enhanceable by e(w^e)¹

(O'Hare, 1991)

w^e has phenotype, enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^e has phenotype, enhanceable by Pale¹

w^e has phenotype, enhanceable by cru¹

w^e has phenotype, enhanceable by whg¹

NOT Enhanced by

Statement

Reference

w^e has phenotype, non-enhanceable by Low¹

(Bhadra et al., 1997)

w^e has phenotype, non-enhanceable by Ufo¹

(Bhadra et al., 1997)

w^e has phenotype, non-enhanceable by Wow^γb

(Birchler et al., 1994)

w^e has phenotype, non-enhanceable by Wow^γe

(Birchler et al., 1994)

w^e has phenotype, non-enhanceable by Wow^ems1

(Birchler et al., 1994)

w^e has phenotype, non-enhanceable by Wow^hd1

(Birchler et al., 1994)

w^e has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^e has phenotype, non-enhanceable by Ts(YSt;2Lt)B110+Ts(YSt;2Rt)R15

(Sabl and Birchler, 1993)

w^e has phenotype, non-enhanceable by Ts(YLt;2Rt)B110+Ts(YLt;2Lt)L138

(Sabl and Birchler, 1993)

w^e has phenotype, non-enhanceable by Ts(YLt;2Rt)G10+Ts(YLt;2Lt)R155

(Sabl and Birchler, 1993)

w^e has phenotype, non-enhanceable by Ts(YLt;2Lt)R14+Ts(YSt;2Rt)L110

(Sabl and Birchler, 1993)

w^e has phenotype, non-enhanceable by Ts(YSt;2Rt)L107+Ts(YSt;2Lt)P59

(Sabl and Birchler, 1993)

w^e has phenotype, non-enhanceable by Ts(YLt;3Lt)B141

(Sabl and Birchler, 1993)

w^e has phenotype, non-enhanceable by Ts(YSt;3Rt)G73+Ts(YSt;3Lt)R128

(Sabl and Birchler, 1993)

w^e has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^e has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^e has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^e has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^e has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^e has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^e has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^e has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^e has pigment cell phenotype, suppressible by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^e has phenotype, suppressible by Ts(YLt;2Rt)L52+Ts(YLt;2Lt)R15

(Sabl and Birchler, 1993)

w^e has phenotype, suppressible by Ts(YSt;2Lt)D20+Ts(YSt;2Rt)L138

(Sabl and Birchler, 1993)

w^e has phenotype, suppressible by Ts(YLt;2Rt)B110+Ts(YSt;2Lt)D20

(Sabl and Birchler, 1993)

w^e has phenotype, suppressible by Ts(YSt;2Lt)H149+Ts(YSt;2Rt)R14

(Sabl and Birchler, 1993)

w^e has phenotype, suppressible by Ts(YSt;3Lt)G48+Ts(YSt;3Rt)R36

(Sabl and Birchler, 1993)

w^e has phenotype, suppressible by Su(w^ch)¹

(O'Hare, 1991)

NOT suppressed by

Statement

Reference

w^e has phenotype, non-suppressible by Low¹

(Bhadra et al., 1997)

w^e has phenotype, non-suppressible by Ufo¹

(Bhadra et al., 1997)

w^e has phenotype, non-suppressible by Wow^γb

(Birchler et al., 1994)

w^e has phenotype, non-suppressible by Wow^γe

(Birchler et al., 1994)

w^e has phenotype, non-suppressible by Wow^ems1

(Birchler et al., 1994)

w^e has phenotype, non-suppressible by Wow^hd1

(Birchler et al., 1994)

w^e has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^e has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^e has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^e has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^e has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

w^e has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^e has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^e has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

w^e has phenotype, non-suppressible by Ts(YSt;2Lt)B110+Ts(YSt;2Rt)R15

(Sabl and Birchler, 1993)

w^e has phenotype, non-suppressible by Ts(YLt;2Rt)B110+Ts(YLt;2Lt)L138

(Sabl and Birchler, 1993)

w^e has phenotype, non-suppressible by Ts(YLt;2Rt)G10+Ts(YLt;2Lt)R155

(Sabl and Birchler, 1993)

w^e has phenotype, non-suppressible by Ts(YLt;2Lt)R14+Ts(YSt;2Rt)L110

(Sabl and Birchler, 1993)

w^e has phenotype, non-suppressible by Ts(YSt;2Rt)L107+Ts(YSt;2Lt)P59

(Sabl and Birchler, 1993)

w^e has phenotype, non-suppressible by Ts(YLt;3Lt)B141

(Sabl and Birchler, 1993)

w^e has phenotype, non-suppressible by Ts(YSt;3Rt)G73+Ts(YSt;3Lt)R128

(Sabl and Birchler, 1993)

w^e has phenotype, non-suppressible by Pcf11^γb

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Pcf11^γc

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Pcf11^γd

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Pcf11^EMS3

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Pcf11^EMS4

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Pcf11^EMS5

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Pcf11^hd1

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Pcf11^γsc

(Rabinow et al., 1991)

w^e has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^e has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^e has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^e has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^e has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^e has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

w^e has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^e has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

Enhancer of

Statement

Reference

w^e/w^e(g) is an enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

w^e/w^e(g) is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Eye colour: the eye pigmentation level of w^e flies is not affected by BEAF-32^AB-KO.

(Roy et al., 2007)

Flies with a w^e/w^e(g) mutant genotype enhance the eye colour defective phenotype of g² and g^50e homozygous mutants leading to a greater reduction of red pigment in the eye. Male w^e, g^53d double mutant flies have lower levels of pigment in the eye than w^e single mutants, leading to a change in eye colour from pink-orange to completely white.