FB2024_03 , released April 23, 2024
Gene: Dmel\Abi
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General Information
Symbol
Dmel\Abi
Species
D. melanogaster
Name
Abelson interacting protein
Annotation Symbol
CG9749
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020510
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Abelson interacting protein (Abi) encodes a protein that interacts with the non-receptor tyrosine kinase encoded by Abl. It contributes to the regulation of actin cytoskeleton organization. It is involved in multiple actin dependent processes including cell adhesion, cell morphogenesis, oogenesis, muscle attachment and axogenesis. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dAbi, Abelson interactor, Ablphilin

Key Links
Genomic Location
Cytogenetic map
88A9-88A9
Sequence location
Recombination map
3-54
RefSeq locus
NT_033777 REGION:14119262..14122420
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (34 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables cadherin binding
inferred from physical interaction with UniProtKB:Q9VW71
(Squarr et al., 2016)
enables protein binding
inferred from physical interaction with FLYBASE:Ptp61F; FB:FBgn0267487
(Huang et al., 2007)
inferred from physical interaction with FLYBASE:ena; FB:FBgn0000578
(Chen et al., 2014)
inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771
(Bogdan and Klambt, 2003)
inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273
(Bogdan and Klambt, 2003)
inferred from physical interaction with FLYBASE:Abl; FB:FBgn0000017
(Juang and Hoffmann, 1999)
(Chia et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables SH3 domain binding
inferred from biological aspect of ancestor with PANTHER:PTN000048906
(GO Reference Genome Project, 2011-)
enables signaling adaptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000048906
(GO Reference Genome Project, 2011-)
Biological Process (22 terms)
Terms Based on Experimental Evidence (21 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Lin et al., 2009, Bogdan et al., 2005)
involved_in axon extension involved in axon guidance
inferred from mutant phenotype
(Stephan et al., 2011)
involved_in cell adhesion mediated by integrin
inferred from mutant phenotype
(Gohl et al., 2010)
involved_in cell adhesion
inferred from mutant phenotype
(Jani and Schock, 2007)
involved_in cell projection assembly
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in central nervous system neuron axonogenesis
inferred from mutant phenotype
(Lin et al., 2009)
involved_in centripetally migrating follicle cell migration
inferred from mutant phenotype
(Squarr et al., 2016)
involved_in chaeta development
inferred from mutant phenotype
(Stephan et al., 2008, Bogdan et al., 2005)
involved_in cortical actin cytoskeleton organization
inferred from mutant phenotype
(Kunda et al., 2003)
involved_in establishment of planar polarity of follicular epithelium
inferred from mutant phenotype
(Squarr et al., 2016)
involved_in lamellipodium assembly
inferred from mutant phenotype
(Huang et al., 2007)
involved_in muscle attachment
inferred from mutant phenotype
(Jani and Schock, 2007)
involved_in neuromuscular junction development
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
(Lin et al., 2009)
involved_in oogenesis
inferred from mutant phenotype
(Chen et al., 2014, Chen et al., 2014)
involved_in photoreceptor cell axon guidance
inferred from mutant phenotype
(Chen et al., 2014)
involved_in positive regulation of cytoskeleton organization
inferred from mutant phenotype
(Chen et al., 2014)
involved_in positive regulation of filopodium assembly
inferred from mutant phenotype
(Squarr et al., 2016)
involved_in positive regulation of G2/M transition of mitotic cell cycle
inferred from mutant phenotype
(Lim et al., 2018)
involved_in positive regulation of stress fiber assembly
inferred from mutant phenotype
(Squarr et al., 2016)
involved_in regulation of actin cytoskeleton organization
inferred from mutant phenotype
(Chen et al., 2014)
involved_in regulation of cell shape
inferred from mutant phenotype
(Kunda et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in neuron migration
inferred from biological aspect of ancestor with PANTHER:PTN000825624
(GO Reference Genome Project, 2011-)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in actin-based cell projection
inferred from direct assay
(Squarr et al., 2016)
located_in basal cortex
inferred from direct assay
(Squarr et al., 2016)
located_in basal part of cell
inferred from direct assay
(Gohl et al., 2010)
located_in lamellipodium membrane
inferred from direct assay
(Huang et al., 2007)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Huang et al., 2007)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273
(Stephan et al., 2011)
part_of SCAR complex
inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771,FLYBASE:SCAR; FB:FBgn0041781
(Stephan et al., 2011)
inferred from direct assay
(Chen et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in actin-based cell projection
inferred from biological aspect of ancestor with PANTHER:PTN000048906
(GO Reference Genome Project, 2011-)
is_active_in lamellipodium
inferred from biological aspect of ancestor with PANTHER:PTN000048906
(GO Reference Genome Project, 2011-)
part_of SCAR complex
inferred from biological aspect of ancestor with PANTHER:PTN000048906
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Abelson interacting protein (Abi) encodes a protein that interacts with the non-receptor tyrosine kinase encoded by Abl. It contributes to the regulation of actin cytoskeleton organization. It is involved in multiple actin dependent processes including cell adhesion, cell morphogenesis, oogenesis, muscle attachment and axogenesis. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
WAVE REGULATORY COMPLEX -
The WAVE Regulatory Complex (WRC) is a multi-subunit complex that controls actin cytoskeletal dynamics. WRC activates the Arp2/3-mediated actin nucleation. WRC contains the nucleation-promoting factor SCAR, a member of the WASP family. (Adapted from FBrf0208042 and FBrf0224564).
Summary (Interactive Fly)

regulates WASP-/WAVE mediated F-actin formation and modulates the activity of the Abelson tyrosine kinase - recruits EGFR to the membrane to promote SOP development

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Abi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4K774)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Abi-RA
FBtr0082910
NM_057915
2379
473
Abi-RB
FBtr0112896
NM_001104315
2373
473
Abi-RC
FBtr0307076
NM_001260161
2291
472
Abi-RD
FBtr0307077
NM_001260162
2391
477
Abi-RE
FBtr0337096
NM_001275630
2376
472
Abi-RF
FBtr0337097
NM_001275631
2294
473
Additional Transcript Data and Comments
Reported size (kB)

1.7 (longest cDNA)

(Juang and Hoffmann, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Abi-PA
FBpp0082371
51.9
473
6.93
Q9Y0S9
NP_477263
AAF55021
Abi-PB
FBpp0111809
51.9
473
6.93
Q9Y0S9
NP_001097785
ABW08669
Abi-PC
FBpp0297919
51.9
472
6.93
A0A0B4KH51
NP_001247090
AFH06408
Abi-PD
FBpp0297920
52.4
477
7.09
A0A0B4K774
NP_001247091
AFH06409
Abi-PE
FBpp0308012
51.9
472
6.93
A0A0B4KH51
NP_001262559
AGB95940
Abi-PF
FBpp0308013
51.9
473
6.93
Q9Y0S9
NP_001262560
AGB95941
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

473 aa isoforms: Abi-PA, Abi-PB, Abi-PF
472 aa isoforms: Abi-PC, Abi-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

473 (aa); 52 (kD observed)

(Juang and Hoffmann, 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Abi using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.64

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
symmetrical commissure
(Lin et al., 2009)
larval longitudinal connective
(Lin et al., 2009)
midline
(Lin et al., 2009)
third instar larval stage
larval ventral nerve cord
(Lin et al., 2009)
embryonic/larval brain
(Lin et al., 2009)
embryonic/larval optic lobe
(Lin et al., 2009)
embryonic/larval optic stalk
(Lin et al., 2009)
photoreceptor neuron
(Lin et al., 2009)
synaptic neuropil
(Lin et al., 2009)
wandering third instar larval stage
eye photoreceptor cell
• axon
(Stephan et al., 2011)
medulla
(Stephan et al., 2011)
lamina
(Stephan et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval brain
(Stephan et al., 2011)
Additional Descriptive Data

Abi is expressed in the brain and ventral nerve cord of the embryonic CNS, specifically in the commissures and longitudinal connectives. There is also some staining along the midline. In third instar larvae expression is observed in several regions of the brain including the neuropil, in axon fascicles of the ventral nerve cord, in photoreceptor cells in the eye disc, and in photoreceptor axons projecting through the optic stalk into the optic lobe.

(Lin et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in actin-based cell projection
inferred from direct assay
(Squarr et al., 2016)
located_in basal cortex
inferred from direct assay
(Squarr et al., 2016)
located_in basal part of cell
inferred from direct assay
(Gohl et al., 2010)
located_in lamellipodium membrane
inferred from direct assay
(Huang et al., 2007)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Huang et al., 2007)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:WASp; FB:FBgn0024273
(Stephan et al., 2011)
part_of SCAR complex
inferred from physical interaction with FLYBASE:Hem; FB:FBgn0011771,FLYBASE:SCAR; FB:FBgn0041781
(Stephan et al., 2011)
inferred from direct assay
(Chen et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Abi in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Abi
Transgenic constructs containing regulatory region of Abi
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel7359
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of P-stage
lethal - all die before end of pupal stage (with AbiKO)
lethal - all die before end of pupal stage (with AbiP2)
lethal - all die before end of pupal stage (with Df(3R)JY19)
lethal - all die during embryonic stage | germline clone | maternal effect | recessive
lethal - all die during P-stage (with Df(3R)su(Hw)7)
partially lethal - majority die, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155
partially lethal - majority die, with Abi5/Df(3R)su(Hw)7, Scer\GAL4how-24B
partially lethal - majority die (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155
partially lethal - majority die (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4how-24B
partially lethal - majority live, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155, Scer\GAL4how-24B
partially lethal - majority live (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155, Scer\GAL4how-24B
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female fertile, with Scer\GAL4da.PU
female semi-sterile, with AbiUASp.AW, Scer\GAL4da.PU
female semi-sterile, with AbiUASp.cCa, Scer\GAL4da.PU
female semi-sterile, with AbiΔ20, Scer\GAL4da.PU
female sterile, with AbiUAS.cSa, Scer\GAL4da.PU
female sterile, with AbiUASp.ΔEna, Scer\GAL4da.PU
female sterile, with AbiΔ20, Scer\GAL4da.PU
Other Phenotypes
Allele
abnormal cell migration, with AbiΔ20, Scer\GAL4da.PU
abnormal cell migration, with AbiΔWIRS.UAS, Scer\GAL4da.PU
abnormal cell polarity, with AbiΔ20, Scer\GAL4da.PU
abnormal cell polarity, with AbiΔWIRS.UAS, Scer\GAL4da.PU
abnormal flight, with Scer\GAL4Mef2.PR
abnormal neuroanatomy
abnormal neuroanatomy | embryonic stage (with AbiKO)
abnormal neuroanatomy | embryonic stage (with AbiP2)
abnormal neuroanatomy | embryonic stage | maternal effect, with Df(3R)JY19/AbiP1
abnormal neuroanatomy | embryonic stage | maternal effect (with Df(3R)JY19), with AbiP2
abnormal neuroanatomy | recessive | third instar larval stage
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage (with Df(3R)su(Hw)7)
abnormal neurophysiology | third instar larval stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4Abi.PK
abnormal neurophysiology | third instar larval stage (with Df(3R)su(Hw)7)
abnormal neurophysiology | third instar larval stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4Abi.PK
majority die during P-stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155
majority die during P-stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4how-24B
majority die during P-stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155
majority die during P-stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4how-24B
some die during embryonic stage | maternal effect | recessive
some die during P-stage
some die during P-stage, with Abi5/Df(3R)su(Hw)7, Scer\GAL4elav-C155, Scer\GAL4how-24B
some die during P-stage (with Df(3R)su(Hw)7), with AbiUAS.Tag:HA, Scer\GAL4elav-C155, Scer\GAL4how-24B
some die during pupal stage (with AbiKO)
some die during pupal stage (with AbiP2)
some die during pupal stage (with Df(3R)JY19)
uncoordinated (with Df(3R)su(Hw)7)
visible, with Scer\GAL4sca-537.4
Phenotype manifest in
Allele
actin-based cell projection | oogenesis, with AbiΔ20, Scer\GAL4da.PU
actin-based cell projection | oogenesis, with AbiΔWIRS.UAS, Scer\GAL4da.PU
actin-based cell projection | oogenesis | somatic clone
actin cytoskeleton, with AbiUASp.AW
actin cytoskeleton, with AbiΔ20
actin filament bundle | oogenesis, with AbiΔ20, Scer\GAL4da.PU
actin filament bundle | oogenesis, with AbiΔWIRS.UAS, Scer\GAL4da.PU
actin filament bundle | oogenesis | somatic clone
centripetal follicle cell | somatic clone
chaeta, with Scer\GAL4sca-537.4
chaeta & mesothoracic tergum | ectopic, with Scer\GAL4sca-537.4
dorsocentral bristle, with Scer\GAL4sca-537.4
egg, with Scer\GAL4da.PU
egg | maternal effect, with AbiΔ20, Scer\GAL4da.PU
egg | maternal effect, with AbiΔWIRS.UAS, Scer\GAL4da.PU
egg | maternal effect, with Scer\GAL4GR1
egg chamber, with AbiUASp.AW, Scer\GAL4da.PU
egg chamber, with AbiΔ20, Scer\GAL4da.PU
egg chamber, with AbiΔWIRS.UAS, Scer\GAL4da.PU
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage (with Df(3R)su(Hw)7)
embryonic/larval plasmatocyte
filamentous actin, with AbiUAS.cSa
filamentous actin, with AbiUASp.ΔEna, Scer\GAL4da.PU
filamentous actin, with AbiΔ20
filamentous actin, with AbiΔ20, Scer\GAL4da.PU
filamentous actin | ectopic, with Scer\GAL4en-e16E
filopodium | oogenesis | somatic clone
follicle cell, with AbiΔ20, Scer\GAL4da.PU
follicle cell, with AbiΔWIRS.UAS, Scer\GAL4da.PU
lamina | third instar larval stage
larval intersegmental nerve branch ISNb of A1-7 | embryonic stage
larval longitudinal connective (with AbiKO)
larval longitudinal connective (with AbiP2)
larval longitudinal connective (with Df(3R)JY19)
larval longitudinal connective | maternal effect, with Df(3R)JY19/AbiP1
larval longitudinal connective | maternal effect (with Df(3R)JY19), with AbiP2
medulla | third instar larval stage
microtubule | third instar larval stage (with Df(3R)su(Hw)7)
NMJ bouton | third instar larval stage (with Df(3R)su(Hw)7)
notopleural bristle | increased number, with Scer\GAL4sca-537.4
nurse cell, with AbiUAS.cSa
nurse cell, with AbiUASp.AW
nurse cell, with AbiUASp.ΔEna, Scer\GAL4da.PU
nurse cell, with AbiΔ20
nurse cell, with AbiΔ20, Scer\GAL4da.PU
outer photoreceptor cell | third instar larval stage
photoreceptor
photoreceptor cell R2 | third instar larval stage
photoreceptor cell R3 | third instar larval stage
photoreceptor cell R4 | third instar larval stage
photoreceptor cell R5 | third instar larval stage
presumptive embryonic/larval nervous system | maternal effect
scutellar bristle, with Scer\GAL4sca-537.4
sensory mother cell, with Scer\GAL4sca-537.4
sensory mother cell | increased number, with Scer\GAL4sca-537.4
tract | somatic clone | third instar larval stage
tract | third instar larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\ABI2
13 of 14
Yes
Yes
Hsap\ABI1
11 of 14
No
Yes
Hsap\ABI3
7 of 14
No
Yes
Hsap\DBNL
1 of 14
No
No
Hsap\MYO1E
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Abi1
11 of 14
Yes
Yes
Rnor\Abi2
10 of 14
No
Yes
Rnor\Abi3
7 of 14
No
Yes
Rnor\Asap1
1 of 14
No
No
Rnor\Cd2ap
1 of 14
No
No
Rnor\Cttn
1 of 14
No
No
Rnor\Myo1e
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Abi2
12 of 14
Yes
Yes
Mmus\Abi1
11 of 14
No
Yes
Mmus\Abi3
7 of 14
No
Yes
Mmus\Asap1
1 of 14
No
No
Mmus\Cttn
1 of 14
No
No
Mmus\Myo1e
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\abi1
6 of 13
Yes
Yes
Xtro\abi2
6 of 13
Yes
Yes
Xtro\abi3
4 of 13
No
Yes
Xtro\myo1e.1
1 of 13
No
No
Xtro\pacsin2
1 of 13
No
No
Danio rerio (Zebrafish) (10)
Drer\abi2a
12 of 14
Yes
Yes
Drer\abi2b
12 of 14
Yes
Yes
Drer\abi1a
10 of 14
No
Yes
Drer\abi1b
10 of 14
No
Yes
Drer\abi3b
6 of 14
No
Yes
Drer\abi3a
5 of 14
No
Yes
Drer\asap1a
1 of 14
No
No
Drer\asap1b
1 of 14
No
No
Drer\pacsin1a
1 of 14
No
No
Drer\srgap1b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\abi-1
12 of 14
Yes
Yes
Cele\sorb-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP001046
11 of 12
Yes
Yes
Agam\AgaP_AGAP004625
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\ABIL1
2 of 13
Yes
Yes
Atha\ABIL2
1 of 13
No
Yes
Atha\ABIL3
1 of 13
No
Yes
Atha\ABIL4
1 of 13
No
Yes
Atha\AT2G46220
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\NBP2
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Abi. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (8)
Aplip1
1 of 13
CAP
1 of 13
cindr
1 of 13
Cortactin
1 of 13
Exn
1 of 13
Lasp
1 of 13
Nost
1 of 13
POSH
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABI2; abl interactor 2
    13 of 14
    606442
        ABI1; abl interactor 1
        11 of 14
        603050
            ABI3; ABI family member 3
            7 of 14
            606363
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Show/hide secondary interactors 
                (data from AllianceMine provided by esyN)
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Other Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please see the Physical Interaction reports below for full details
                RNA-RNA
                Physical Interaction
                Assay
                References
                Abi - mir-252
                luminiscence technology, phenotype-based detection assay, western blot
                (Lim et al., 2018)
                protein-protein
                Physical Interaction
                Assay
                References
                Abi - Abl
                pull down, western blot, enzymatic study, inferred by author
                (Lin et al., 2004, Juang and Hoffmann, 1999)
                Abi - Cdc42
                pull down, western blot
                (Fricke et al., 2009)
                Abi - Cdk1
                two hybrid, pull down, anti tag western blot, western blot
                (Lin et al., 2004)
                Abi - Cip4
                anti bait coimmunoprecipitation, western blot, two hybrid
                (Fricke et al., 2009)
                Abi - Cyfip
                anti bait coimmunoprecipitation, peptide massfingerprinting
                (Gautier et al., 2011)
                Abi - Egfr
                anti bait coimmunoprecipitation, western blot
                (Stephan et al., 2008)
                Abi - HSPC300
                pull down, molecular sieving, molecular weight estimation by staining
                (Chen et al., 2014, Chia et al., 2014, Ismail et al., 2009)
                Abi - Hem
                molecular sieving, western blot, pull down, two hybrid
                (Kim et al., 2019, Stephan et al., 2011, Bogdan et al., 2005, Bogdan and Klambt, 2003)
                Abi - Hexo2
                anti tag coimmunoprecipitation, western blot
                (White-Grindley et al., 2014)
                Abi - Lar
                pull down, western blot
                (Squarr et al., 2016)
                Abi - Ptp61F
                pull down, anti tag western blot
                (Huang et al., 2007)
                Abi - SCAR
                bimolecular fluorescence complementation, fluorescence microscopy, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, two hybrid, pull down, molecular sieving
                (Kim et al., 2019, Chen et al., 2014, Stephan et al., 2011, Gohl et al., 2010, Fricke et al., 2009, Bogdan et al., 2005)
                Abi - WASp
                pull down, western blot, two hybrid, molecular sieving, anti bait coimmunoprecipitation
                (Kim et al., 2019, Stephan et al., 2011, Bogdan et al., 2005, Bogdan and Klambt, 2003)
                Abi - ena
                pull down, western blot, anti tag western blot, far western blotting, peptide array
                (Chen et al., 2014)
                Abi - kug
                pull down, molecular weight estimation by staining
                (Squarr et al., 2016)
                Abi - orb2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (White-Grindley et al., 2014)
                Summary of Genetic Interactions
                esyN Network Diagram
                Show/hide secondary interactors 
                (data from AllianceMine provided by esyN)
                esyN Network Key:
                Suppression
                Enhancement
                Other Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Abi
                suppressible
                Abl
                (Lin et al., 2009)
                Abi
                suppressible
                SCAR
                (Stephan et al., 2011)
                Abi
                enhanceable
                SCAR
                (Kannan et al., 2017)
                Abi
                suppressible
                WASp
                (Bogdan et al., 2005)
                Abi
                suppressible
                wit
                (Kim et al., 2019)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Abl
                suppressible
                Abi
                (Kim et al., 2019, Lin et al., 2009)
                Dora
                suppressible
                Abi
                (Molina-Pelayo et al., 2022)
                Lar
                enhanceable
                Abi
                (Squarr et al., 2016)
                Rac1
                suppressible
                Abi
                (Kim et al., 2019)
                SCAR
                enhanceable
                Abi
                (Kannan et al., 2017)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-54
                Cytogenetic map
                88A9-88A9
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                88A9-88A9
                Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                88A-88B
                (determined by in situ hybridisation)
                (Gangadharan and Tear, 1999)
                Experimentally Determined Recombination Data
                Location

                3-54

                (FlyBase, 2016)

                3-52.7

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (15)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (93)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  monoclonal

                  (Kim et al., 2019)

                  polyclonal

                  (Gautier et al., 2011, Stephan et al., 2011, Georgiou and Baum, 2010)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                      (Stroschein-Stevenson et al., 2006)

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)

                      dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

                      (Rogers et al., 2003)
                      Relationship to Other Genes
                      Source for database merge of
                      Additional comments
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: Abi CG9749

                      (Zheng, 1999.11)
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (9)
                      Reported As
                      Symbol Synonym
                      Abi
                      (Chan et al., 2023, Fernandez-Gonzalez and Harris, 2023, Nieken et al., 2023, Adashev et al., 2022, Molina-Pelayo et al., 2022, Rout et al., 2022, Zhou et al., 2022, Hirschhäuser et al., 2021, Pang et al., 2021, Popkova et al., 2021, Karageorgiou et al., 2020, Song and Zhou, 2020, Gao et al., 2019, Kim et al., 2019, Gene Disruption Project members, 2018-, Lim et al., 2018, Barlan et al., 2017, Transgenic RNAi Project members, 2017-, Squarr et al., 2016, Chen et al., 2014, Chen et al., 2014, Huelsmann, 2014.12.18, Huelsmann, 2014.12.18, Valanne, 2014, White-Grindley et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Reed et al., 2012, Rohn et al., 2011, Ulvila et al., 2011, Zhu and Bhat, 2011, Zhu and Bhat, 2011, D'Ambrosio and Vale, 2010, Georgiou and Baum, 2010, Gohl et al., 2010, Hilger et al., 2009, Elwell et al., 2008, Stephan et al., 2008, Chen et al., 2007, Huang et al., 2007, Huang et al., 2007, Jani and Schock, 2007, Kondylis et al., 2007, Qurashi et al., 2007, Stroschein-Stevenson et al., 2006, Bogdan et al., 2005, Rogers et al., 2003)
                      Abi-1
                      (Tepass et al., 2002)
                      Ablphilin
                      (Gangadharan, 1999.9.16, Gangadharan and Tear, 1999)
                      CG9749
                      (Çiçek et al., 2016, White-Grindley et al., 2014, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Rogers et al., 2003, Ramet et al., 2002)
                      abi
                      (Deng et al., 2021, Santa-Cruz Mateos et al., 2020, Crest et al., 2017, Kannan et al., 2017, Hamp et al., 2016, Isabella and Horne-Badovinac, 2016, Gupta et al., 2014, Kondylis et al., 2011, Stephan et al., 2011, Fricke et al., 2009, Lin et al., 2009)
                      dAbi
                      (Chia et al., 2014, Wang et al., 2010, Ismail et al., 2009, Lin et al., 2004, Wahlstrom et al., 2001, Juang and Hoffmann, 1999)
                      Name Synonyms
                      Abelson Interacting Protein
                      (Chang et al., 2008, Juang et al., 1997)
                      Abelson interacting protein
                      (Gupta et al., 2014, Wang et al., 2010, Lin et al., 2009)
                      Abelson interactor
                      (Stephan et al., 2011, Gohl et al., 2010, Stephan et al., 2008)
                      Secondary FlyBase IDs
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        Study result (0)
                        Result
                        Result Type
                        Title
                        External Crossreferences and Linkouts ( 62 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                        FlyMine - An integrated database for Drosophila genomics
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        MARRVEL_MODEL - MARRVEL (model organism gene)
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                        Flygut - An atlas of the Drosophila adult midgut
                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                        References (129)