Ismail, A.M., Padrick, S.B., Chen, B., Umetani, J., Rosen, M.K. (2009). The WAVE regulatory complex is inhibited.  Nat. Struct. Mol. Biol. 16(5): 561--563.

FBrf0208042

Research paper

The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

PMC2716658 (PMC) (EuropePMC)