WAVE, l(2)k03107, dWAVE, SCAR/WAVE, l(2)k13811
promotes actin polymerization via Arp2/3 protein complex - Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion
Please see the JBrowse view of Dmel\SCAR for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
613 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SCAR using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: expression assayed in cultured S2 cells
SCAR protein presents as a doublet on Western blots; one isoform may represent posttranslational modification.
SCAR protein is present in early blastoderm embryos where it colocalizes with filamentous actin structures. It is also expressed in the axons of the central nervous system in later embryos.
JBrowse - Visual display of RNA-Seq signals
View Dmel\SCAR in JBrowse2-44
2-37.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans, Escherichia coli, Staphylococcus aureus and latex beads compared to untreated cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: reduced F-actin and altered cell shape. Kc167 cells show change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
SCAR function is essential for cytoplasmic organization in the blastoderm, axon development in the central nervous system, egg chamber structure during oogenesis, and adult eye morphology.
SCAR may be involved in embryonic central nervous system development.
Source for merge of: l(2)k03107 l(2)k13811
Source for merge of: SCAR l(2)k03107
Source for merge of: SCAR BEST:SD02991
Source for merge of: SCAR CG4636
Source for merge of SCAR CG4636 was sequence comparison ( date:000607 ).
