FlyBase Allele Report: Dmel\Egfr[UAS.cBa]

The expression of Egfr^UAS.cBa during adulthood under the combined control of Scer\GAL4^ap.PU and Gal80[ts] does not induce tumors, as compared to controls.

(Andrejeva et al., 2018)

Expressing Egfr^UAS.cBa under the control of Scer\GAL4^GMR.PU leads to a rough eye phenotype.

(Khare et al., 2017)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^crq.PO results in significantly increased concentration of circulating hemocytes in third instar larvae, as compared to controls.

(Kim et al., 2017)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PU results in small, rough eyes.

(Macagno et al., 2014)

Expression of Egfr^Scer\UAS.cBa in the wing, under the control of Scer\GAL4^Bx-MS1096, generates ectopic and defective wing vein formation. Addition of KSOP1009 to the food media suppresses defective wing vein formation.

(Park et al., 2013)

Third instar larvae expressing Egfr^UAS.cBa under the control of Scer\GAL4^ap-md544 (in combination with a Gal80[ts] transgene to inhibit expression until early third instar) do not pupate and can continue to grow for up to 5 days at 29[o]C. Their wing discs are severely overgrown in the dorsal compartment with dying cells dropping out of the epithelial layer. Otherwise, apico-basal polarity and epithelial organization in wing discs are similar to wild-type controls.

Somatic clones expressing Egfr^UAS.cBa under the control of Scer\GAL4^ap-md544 appear to be sorted out and eliminated from the wing disc epithelium in third instar larvae.

Expressing Egfr^UAS.cBa under the control of Scer\GAL4^hh.PU results in an overgrown wing disc dorsal compartment in third instar larvae.

(Herranz et al., 2012)

Neuronal expression of Egfr^Scer\UAS.cBa (under the control of Scer\GAL4^elav-C155) throughout development, until the adult stage (where Scer\GAL80^ts.αTub84B is induced) does not reduce ethanol sensitivity. Neuronal expression only after eclosion of the adult fly also fails to reduce ethanol sensitivity.

(Eddison et al., 2011)

Border follicle cell clusters in females expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^slbo.2.6 show significantly reduced net cluster movement compared to wild type in both early and late phases of posterior migration. Tumbling is increased compared to wild type in both phases. Fewer cellular extensions are observed overall, but the strong bias for extensions from the front of the border cell cluster is retained.

(Poukkula et al., 2011)

Expression of Egfr^Scer\UAS.cBa under the control of one of Scer\GAL4^elav-C155, Scer\GAL4^Ilp2.PR or Scer\GAL4^ple.PF results in flies with increased resistance to ethanol-induced sedation compared to control flies.

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF results in a very strong rough eye phenotype with prominent blistering in the dorsal anterior section of the eye.

The projection pattern of brain insulin-producing cells appears unaffected in adults expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^Ilp2.PR.

The projection pattern of brain ple-positive dopaminergic cells appears unaffected in adults expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^ple.PF.

(Corl et al., 2009)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF results in a rough-eye phenotype.

Expression of Egfr^Scer\UAS.cBa in the wing under the control of Scer\GAL4^dpp.blk1 results in elongation of the wing.

(Mao and Freeman, 2009)

Expression of Egfr^Scer\UAS.cBa in the wing using Scer\GAL4^Bx-MS1096 results in wing overgrowth and aberrant wing venation.

(Lyulcheva et al., 2008)

Cells expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^c522 are preferentially located at the front of the cluster during border cell posterior migration in mosaic border cell clusters consisting of both wild-type and mutant cells.

(Bianco et al., 2007)

Overexpression of Egfr^Scer\UAS.cBa in the developing retina, under the control of Scer\GAL4^GMR.PF causes a rough eye.

(Hagedorn et al., 2006)

Overexpression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4⁷⁹⁶ increases cell size but does not affect synapse number.

(Martin-Pena et al., 2006)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^bi-md653 results in a mild haltere-to-wing transformation as the capitellum of the halteres produce between three and five wing margin-type bristles.

(Pallavi et al., 2006)

Border cell migration occurs normally in Egfr^Scer\UAS.cBa; Scer\GAL4^slbo.2.6 egg chambers. By oogenesis stage 10, sporadic follicle cells in these egg chambers accumulate filamentous actin in the cortex.

(Jekely et al., 2005)

Expression of Egfr^Scer\UAS.cBa in border cells, driven by Scer\GAL4^slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte.

(Medioni and Noselli, 2005)

When expression is driven by Scer\GAL4^He.PZ, hemocyte proliferation is increased and lamellocyte numbers and crystal cells are unaffected.

(Zettervall et al., 2004)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^sca-537.4 has a very weak effect on a number of notum bristles.

(Escudero et al., 2003)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF results in a general disorganisation of the ommatidia.

(Kramer et al., 2003)

Egfr^Scer\UAS.cBa; Scer\GAL4^Bx-MS1096 flies have wings with moderate amounts of ectopic vein formation, concentrated around the distal ends of the longitudinal veins. Egfr^DN3.Scer\UAS; Egfr^Scer\UAS.cBa; Scer\GAL4^Bx-MS1096 flies have a much more severe wing phenotype: wings are small rounded with large amounts of ectopic vein material.

(Guichard et al., 2002)

The expression of Egfr^Scer\UAS.cBa completely eliminated tibial and basitarsal bracts when driven by Scer\GAL4^sca-537.4, and almost completely eliminated them when driven by Scer\GAL4^Dll-md23 (None of bracts in the tibia and 10% in the basitarsus of the second leg remain.) Also in 1 in 10 legs (when driven by Scer\GAL4^Dll-md23 or Scer\GAL4^sca-537.4) a transformation of the huge 'apical' bristle into a chemosensory bristle of ordinary size is seen.

(Held, 2002)

When expression is driven by Scer\GAL4^ap-md544 extra macrochatae develop on the notum, but only in the vicinity of extant ones.

(Culi et al., 2001)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^ptc-559.1 results in wings with fusion of veins 3 and 4 in the proximal portion of the wing, while more distally the spacing of veins 3 and 4 appears normal. Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 does not cause formation of ectopic veins between wing veins 3 and 4, although a significant amount of ectopic vein material is induced anterior to vein 3 and posterior to vein 4.

(Mohler et al., 2000)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF causes some ectopic wing vein formation.

(Robertson et al., 2000)

Expression of Egfr^Scer\UAS.cBa under the control of both Scer\GAL4^twi.PG and Scer\GAL4^how-24B in a wild-type background has no effect on muscle development.

(Buff et al., 1998)

Scer\GAL4^GMR.PF induced expression causes complete loss of the adult retina, some interommatidial bristles remain.

(Freeman, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has hyperplasia phenotype, enhanceable by psq^KK111691, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has hyperplasia phenotype, enhanceable by psq^GL00342, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has hyperplasia phenotype, enhanceable by psq^JF03109, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has hyperplasia phenotype, enhanceable by trol^EP1160, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has hyperplasia phenotype, enhanceable by dpp^UAS.cSa/wg^UAS.cLa, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has abnormal size | third instar larval stage phenotype, enhanceable by BacA\p35^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has abnormal size | third instar larval stage phenotype, enhanceable by mir-ban^C.UAS.EGFP, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has abnormal size | third instar larval stage phenotype, enhanceable by Diap1^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has abnormal size | third instar larval stage phenotype, enhanceable by Socs36E^GD8929, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^hh.PU has abnormal size | third instar larval stage phenotype, enhanceable by Socs36E^EY11/Socs36E^EY11

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has visible | homeotic phenotype, enhanceable by aos^unspecified/argos[+]

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has visible | homeotic phenotype, enhanceable by Ubx¹/Ubx[+]

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has visible | homeotic phenotype, enhanceable by vn^UAS.cSa, Scer\GAL4^bi-md653

(Pallavi et al., 2006)

NOT Enhanced by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has hyperplasia phenotype, non-enhanceable by wg^UAS.cLa, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has hyperplasia phenotype, non-enhanceable by dpp^UAS.cSa, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Suppressed by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, suppressible by Nrg^HMS01638, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, suppressible by Nrg^HMS01638, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, suppressible by caps^ID.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, suppressible by caps^ID.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, suppressible by SCAR^GD11380, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, suppressible by SCAR^GD11380, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, suppressible by dia^GL00408, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, suppressible by Ecol\lexA^GMR15B03/dia^RNAi.lexAop

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, suppressible by Ecol\lexA^GMR15B03/dia^RNAi.lexAop

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, suppressible by btl^DN.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, suppressible by btl^DN.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has abnormal cell polarity | larval stage phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has abnormal cell migration | larval stage phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased mortality during development phenotype, suppressible by Nrg^HMS01638, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased mortality during development phenotype, suppressible by caps^ID.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased mortality during development phenotype, suppressible by SCAR^GD11380, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased mortality during development phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased mortality during development phenotype, suppressible by btl^DN.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has partially lethal phenotype, suppressible by Nrg^HMS01638, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has partially lethal phenotype, suppressible by caps^ID.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has partially lethal phenotype, suppressible by SCAR^GD11380, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has partially lethal - majority live phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^crq.PO has increased cell number | third instar larval stage phenotype, suppressible by Cbl^L.UAS, Scer\GAL4^crq.PO

(Kim et al., 2017)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^JF03109 has neoplasia phenotype, suppressible | partially by dpp^JF01371, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^JF03109 has neoplasia phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^JF03109 has neoplasia phenotype, suppressible by trol^GL01153, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^JF03109 has neoplasia phenotype, suppressible by trol^KK105502, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^JF03109 has neoplasia phenotype, suppressible by rpr^lexAop.cHa/Ecol\lexA^GMR15B03

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^JF03109 has neoplasia phenotype, suppressible by Mad^KK109050, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ptc-559.1 has lethal phenotype, suppressible | partially by Fak^UAS.Tag:HA, Scer\GAL4^ptc-559.1

(Macagno et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal size | third instar larval stage phenotype, suppressible | partially by dome^ΔCYT.UAS, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal size | third instar larval stage phenotype, suppressible | partially by Stat92E^RNAi.UAS.cHa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has increased cell death | third instar larval stage phenotype, suppressible by Diap1^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has abnormal size | third instar larval stage phenotype, suppressible by upd1^UAS.cZa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has increased cell death | third instar larval stage phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF has visible phenotype, suppressible by hppy^RB.UAS, Scer\GAL4^GMR.PF

(Corl et al., 2009)

NOT suppressed by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, non-suppressible by ds^HMS00759, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, non-suppressible by ds^HMS00759, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, non-suppressible by ft^HMS00932, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, non-suppressible by ft^HMS00932, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype, non-suppressible by fj^HMS01310, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype, non-suppressible by fj^HMS01310, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, dia^HM05027, psq^KK111691 has neoplasia | larval stage phenotype, non-suppressible by Nrg^HMS01638, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^crq.PO has increased cell number | third instar larval stage phenotype, non-suppressible by Cbl^L.Δ70Z.UAS, Scer\GAL4^crq.PO

(Kim et al., 2017)

Enhancer of

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544 is an enhancer of abnormal size | third instar larval stage phenotype of Scer\GAL4^ap-md544, mir-ban^C.UAS.EGFP

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 is an enhancer of visible | homeotic phenotype of Scer\GAL4^bi-md653, vn^UAS.cSa

(Pallavi et al., 2006)

Scer\GAL4^bi-md653/Egfr^UAS.cBa is an enhancer of visible | homeotic phenotype of Ubx¹

(Pallavi et al., 2006)

Egfr^UAS.cBa/Scer\GAL4^{Ubx-lac1-Gal4} is an enhancer of visible | homeotic phenotype of Ubx^lac1-GAL4

(Pallavi et al., 2006)

Suppressor of

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\KCNC3^R423H.UAS, Scer\GAL4^GMR.PU

(Khare et al., 2017)

Egfr^UAS.cBa, Scer\GAL4^GMR.PU is a suppressor | partially of decreased size | adult stage phenotype of Hsap\KCNC3^R423H.UAS, Scer\GAL4^GMR.PU

(Khare et al., 2017)

Other

Statement

Reference

Egfr^UAS.cBa, Nrg^{167.UAS.APEX2,EGFP}, Scer\GAL4^bun-GSG5961 has increased occurrence of cell division | adult stage phenotype

(Resnik-Docampo et al., 2021)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, dia^HM05027, psq^KK111691 has fertile phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, dia^HM05027, psq^KK111691 has visible | adult stage phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, btl^DN.UAS, psq^KK111691 has lethal - all die before end of pupal stage phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has abnormal developmental rate | larval stage phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has abnormal cell polarity | larval stage phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has increased cell number | larval stage phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has lethal - all die before end of larval stage phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia | larval stage phenotype

(Fereres et al., 2019)

Aldh7A1^KK109006, Egfr^UAS.cBa, Scer\GAL4^ap.PU has neoplasia | adult stage phenotype

(Andrejeva et al., 2018)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^GL00342 has neoplasia phenotype

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^JF03109 has neoplasia phenotype

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, trol^EP1160 has neoplasia phenotype

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, dpp^UAS.cSa, wg^UAS.cLa has neoplasia phenotype

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has neoplasia phenotype

(Herranz et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, mir-ban^C.UAS.EGFP has neoplasia | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal size | somatic clone | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has neoplasia phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has abnormal planar polarity | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has neoplasia | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^hh.PU, Socs36E^EY11 has neoplasia | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^sca-537.4, ed^ΔECD.UAS has visible phenotype

(Escudero et al., 2003)

Egfr^UAS.cBa, Scer\GAL4^Bx-MS1096, rho^UAS.cBa has visible phenotype

(Guichard et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by BacA\p35^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by mir-ban^C.UAS.EGFP, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Diap1^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Socs36E^GD8929, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^hh.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Socs36E^EY11/Socs36E^EY11

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, enhanceable by Pvr^DN.UASp, Scer\GAL4^slbo.2.6

(Poukkula et al., 2011)

Egfr^UAS.cBa, Scer\GAL4^slbo.2.6 has border follicle cell phenotype, enhanceable by Pvf1^EP1624, Scer\GAL4^slbo.2.6

(Poukkula et al., 2011)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Fas2^EB112/Fas2[+]

(Mao and Freeman, 2009)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has capitellum phenotype, enhanceable by aos^unspecified/argos[+]

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has wing margin bristle | ectopic phenotype, enhanceable by aos^unspecified/argos[+]

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has capitellum phenotype, enhanceable by Ubx¹/Ubx[+]

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has wing margin bristle | ectopic phenotype, enhanceable by Ubx¹/Ubx[+]

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has capitellum phenotype, enhanceable by vn^UAS.cSa, Scer\GAL4^bi-md653

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 has wing margin bristle | ectopic phenotype, enhanceable by vn^UAS.cSa, Scer\GAL4^bi-md653

(Pallavi et al., 2006)

NOT Enhanced by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by aux^I670K/aux[+]

(Hagedorn et al., 2006)

Suppressed by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, suppressible by Nrg^HMS01638, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, suppressible by caps^ID.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, suppressible by SCAR^GD11380, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, suppressible by dia^GL00408, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, suppressible by Ecol\lexA^GMR15B03/dia^RNAi.lexAop

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has embryonic/larval tracheal section phenotype, suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, suppressible by btl^DN.UAS, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^crq.PO has hemocyte | increased number | third instar larval stage phenotype, suppressible by Cbl^L.UAS, Scer\GAL4^crq.PO

(Kim et al., 2017)

Egfr^UAS.cBa, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Fak^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc dorsal compartment | third instar larval stage phenotype, suppressible | partially by dome^ΔCYT.UAS, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc dorsal compartment | third instar larval stage phenotype, suppressible | partially by Stat92E^RNAi.UAS.cHa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, suppressible by Diap1^UAS.cUa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, suppressible by upd1^UAS.cZa, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by hppy^RB.UAS, Scer\GAL4^GMR.PF

(Corl et al., 2009)

Egfr^UAS.cBa, Scer\GAL4^Bx-MS1096 has wing phenotype, suppressible by pico^RNAi.UAS

(Lyulcheva et al., 2008)

NOT suppressed by

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, non-suppressible by fj^HMS01310, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, dia^HM05027, psq^KK111691 has wing disc phenotype, non-suppressible by Nrg^HMS01638, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Nrg^HMS01638, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, non-suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, non-suppressible by ds^HMS00759, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, non-suppressible by ft^HMS00932, Scer\GAL4^ap-md544

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^crq.PO has hemocyte | increased number | third instar larval stage phenotype, non-suppressible by Cbl^L.Δ70Z.UAS, Scer\GAL4^crq.PO

(Kim et al., 2017)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF has ommatidium phenotype, non-suppressible by foxo^UAS.cKa, Scer\GAL4^GMR.PF

(Kramer et al., 2003)

Enhancer of

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Scer\GAL4^ap-md544, mir-ban^C.UAS.EGFP

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^slbo.2.6 is an enhancer of border follicle cell phenotype of Pvr^DN.UASp, Scer\GAL4^slbo.2.6

(Poukkula et al., 2011)

Egfr^UAS.cBa, Scer\GAL4^slbo.2.6 is an enhancer of border follicle cell phenotype of Pvf1^EP1624, Scer\GAL4^slbo.2.6

(Poukkula et al., 2011)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

Scer\GAL4^bi-md653/Egfr^UAS.cBa is an enhancer of capitellum phenotype of Ubx¹

(Pallavi et al., 2006)

Scer\GAL4^bi-md653/Egfr^UAS.cBa is an enhancer of wing margin bristle | ectopic phenotype of Ubx¹

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 is an enhancer of wing margin bristle | ectopic phenotype of Scer\GAL4^bi-md653, vn^UAS.cSa

(Pallavi et al., 2006)

Egfr^UAS.cBa/Scer\GAL4^{Ubx-lac1-Gal4} is an enhancer of capitellum phenotype of Ubx^lac1-GAL4

(Pallavi et al., 2006)

Egfr^UAS.cBa/Scer\GAL4^{Ubx-lac1-Gal4} is an enhancer of wing margin bristle | ectopic phenotype of Ubx^lac1-GAL4

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^bi-md653 is an enhancer of capitellum phenotype of Scer\GAL4^bi-md653, vn^UAS.cSa

(Pallavi et al., 2006)

Egfr^UAS.cBa/Scer\GAL4^slbo.2.6 is an enhancer of border follicle cell | somatic clone phenotype of Cbl^F165

(Jekely et al., 2005)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF is an enhancer of photoreceptor cell R7 phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF is an enhancer of wing vein phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

Suppressor of

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\KCNC3^R423H.UAS, Scer\GAL4^GMR.PU

(Khare et al., 2017)

NOT Suppressor of

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^GMR.PF is a non-suppressor of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, foxo^UAS.cKa

(Kramer et al., 2003)

Egfr^UAS.cBa, Scer\GAL4^GMR.PF is a non-suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, foxo^UAS.cKa

(Kramer et al., 2003)

Other

Statement

Reference

Egfr^UAS.cBa, Nrg^{167.UAS.APEX2,EGFP}, Scer\GAL4^bun-GSG5961 has adult posterior midgut epithelium phenotype

(Resnik-Docampo et al., 2021)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, dia^HM05027, psq^KK111691 has wing blade phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691 has embryonic/larval tracheal section phenotype

(Fereres et al., 2019)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, mir-ban^C.UAS.EGFP has wing disc | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^ap-md544, Socs36E^GD8929 has wing disc | somatic clone | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^hh.PU, Socs36E^EY11 has wing disc | third instar larval stage phenotype

(Herranz et al., 2012)

Egfr^UAS.cBa, Scer\GAL4^{Ubx-lac1-Gal4}, Ubx^lac1-GAL4 has pigment cell & haltere phenotype

(Pallavi et al., 2006)

Egfr^UAS.cBa, Scer\GAL4^slbo.2.6, spri^6G1 has border follicle cell phenotype

(Jekely et al., 2005)

Egfr^UAS.cBa, Scer\GAL4^sca-537.4, ed^ΔECD.UAS has macrochaeta | ectopic phenotype

(Escudero et al., 2003)

Egfr^UAS.cBa, Scer\GAL4^Bx-MS1096, rho^UAS.cBa has wing phenotype

(Guichard et al., 1999)

Egfr^UAS.cBa, Scer\GAL4^Bx-MS1096, rho^UAS.cBa has wing vein phenotype

(Guichard et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

All individuals co-expressing psq^KK111691 and Egfr^UAS.cBa under the control of Scer\GAL4^ap-md544 during larval stages (using Gal80[ts] for the temporal regulation of expression) are developmentally delayed and die at the third instar stage; their wing discs form epithelial tumors that exhibit cell polarity defects (i.e. Dlg mis-localization), associated with higher numbers of myoblasts and a more extensive/branched trachea than normal across the disc. The tumors metastasize to distant tissues in the larva.

The tumor phenotype (size and disc distortion) and the increased myoblast numbers are partially suppressed by the additional co-expression of either Nrg^HMS01638, caps^ID.UAS, SCAR^GD11380, or dia^HM05027, but not of ds^HMS00759, fj^HMS01310 or ft^HMS00932; dia^HM05027 also partially suppresses the increased tracheation. There is no further tumor suppression by Nrg^HMS01638, dia^HM05027 combined. Additional co-expression of dia^dsRNA.lexAop under the control of Ecol\lexA^GMR15B03 also partially suppresses the tumors and the increased myoblasts.

Co-expression of dia^HM05027 under the control of Scer\GAL4^ap-md544 also rescues most Scer\GAL4^ap-md544>psq^KK111691,Egfr^UAS.cBa individuals to adulthood; these adults are fertile and their only visible phenotype is wing blade defects.

(Fereres et al., 2019)

The co-expression of Egfr^UAS.cBa and Aldh7A1^KK109006 during adulthood under the combined control of Scer\GAL4^ap.PU and Gal80[ts] induces tumors, as compared to controls.

(Andrejeva et al., 2018)

The co-expression of Egfr^UAS.cBa and pnut^GD1512 from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] does not leads to the formation of tumors in the third instar larval wing disc.

(Gerlach et al., 2018)

The increased concentration of circulating hemocytes observed in third instar larvae expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^crq.PO is suppressed by co-expression of Cbl^L.Scer\UAS but not Cbl^{L.Δ70Z.Scer\UAS}.

(Kim et al., 2017)

Expression of psq^KK111691 massively enhances the overproliferation seen in wing discs expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^ap-md544. The discs grow as multilayered masses. The larvae do not enter pupariation and the discs continue to grow, often filling the anterior half of the larva. The cells lose their apical-basal polarity and cells metastasise into internal organs including the gut and malpighian tubules. The basement membranes have degraded in these discs. Mutant epithelial cells are intermingled with wild type mesenchymal cells that resemble the adepithelial cells. Expression of psq^KK111691 and Egfr^Scer\UAS.cBa specifically in the wing pouch under the control of Scer\GAL4^nub.PU produces epithelial hyperplasia but no tumors. The proliferation of both the epithelial and mesenchymal cells in the tumor is rapid, with most of the mesenchymal proliferation taking place close to the epithelial layer.

Expression of psq^GL00342 massively enhances the overproliferation seen in wing discs expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^ap-md544.

Expression of psq^JF03109 massively enhances the overproliferation seen in wing discs expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^ap-md544.

Expression of dpp^JF01371 partially suppresses the growth of the massive wing disc tumors seen when Egfr^Scer\UAS.cBa and psq^KK111691 are expressed under the control of Scer\GAL4^ap-md544.

Expression of wg^GD5007 partially suppresses the growth of the massive wing disc tumors seen when Egfr^Scer\UAS.cBa and psq^KK111691 are expressed under the control of Scer\GAL4^ap-md544.

Expression of trol^GL01153 suppresses the growth of the massive wing disc tumors seen when Egfr^Scer\UAS.cBa and psq^KK111691 are expressed under the control of Scer\GAL4^ap-md544. Apicobasal polarity and tissue organisation is restored to the epithelial cells.

Expression of trol^KK105502 suppresses the growth of the massive wing disc tumors seen when Egfr^Scer\UAS.cBa and psq^KK111691 are expressed under the control of Scer\GAL4^ap-md544. Apicobasal polarity and tissue organisation is restored to the epithelial cells.

Co-expression of trol^EP1160 and Egfr^Scer\UAS.cBa in the wing disc under the control of Scer\GAL4^ap-md544 results in massive overgrowth and neoplastic transformation. Mutant epithelial cells intermingle with wild type mesenchymal cells.

Ablating adepithelial cells through expression of rpr^{Ecol\lexAop.cHa} under the control of Ecol\lexA^GMR15B03 suppresses the neoplastic transformation seen when psq^KK111691 and Egfr^Scer\UAS.cBa are co-expressed under the control of Scer\GAL4^ap-md544.

Expression of either wg^Scer\UAS.cLa or dpp^Scer\UAS.cSa does not enhance the overproliferation seen in wing discs expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^ap-md544. However, co-expression of wg^Scer\UAS.cLa and dpp^Scer\UAS.cSa with Egfr^Scer\UAS.cBa produces tumors consisting of epithelial and mesenchymal cell populations and showing loss of epithelial integrity.

Expression of Mad^KK109050 does not suppress the growth of the massive wing disc tumors seen when Egfr^Scer\UAS.cBa and psq^KK111691 are expressed under the control of Scer\GAL4^ap-md544. Apicobasal polarity and tissue organisation is restored to the epithelial cells.

Expression of Mad^{dsRNA.IVS.13xEcol\lexAop} in adepithelial cells under the control of Ecol\lexA^GMR15B03 suppresses the neoplastic transformation seen when psq^KK111691 and Egfr^Scer\UAS.cBa are co-expressed under the control of Scer\GAL4^ap-md544.

Expression of pan^ΔN.Scer\UAS suppresses the growth of the massive wing disc tumors seen when Egfr^Scer\UAS.cBa and psq^KK111691 are expressed under the control of Scer\GAL4^ap-md544. Apicobasal polarity and tissue organisation is restored to the epithelial cells.

(Herranz et al., 2014)

Expression of Fak^{Scer\UAS.T:Ivir\HA1} suppresses the reduction in eye size seen in flies expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PU.

Expression of Fak^{Scer\UAS.T:Ivir\HA1} partially suppresses the almost total lethality seen when Egfr^Scer\UAS.cBa is expressed under the control of Scer\GAL4^ptc-559.1. The proportion of surviving flies is increased to approximately 60%.

(Macagno et al., 2014)

Co-expressing Egfr^UAS.cBa with either mir-ban^C.UAS.EGFP or Socs36E^GD8929 under the control of Scer\GAL4^ap-md544 (in combination with a Gal80[ts] transgene to inhibit expression until early third instar) or expression of Egfr^UAS.cBa under the control of Scer\GAL4^hh.PU in a Socs36E^EY11/Socs36E^EY11 background result in severely overgrown and deformed wing discs with a disrupted epithelial organization (resembling tissues undergoing a neoplastic transformation) in third instar larvae. Wing discs co-expressing Egfr^UAS.cBa and Socs36E^GD8929 lose apico-basal polarity and cells metastasize invading other tissues of the larva. Transplantation of imaginal disc fragments co-expressing Egfr^UAS.cBa and Socs36E^GD8929 under the control of Scer\GAL4^ap-md544 into the abdomens of adult hosts form tumors, grow rapidly, metastasize and kill the host flies.

Somatic clones co-expressing Egfr^UAS.cBa and Socs36E^GD8929 under the control of Scer\GAL4^ap-md544 in wing discs of third instar larvae overgrow, fuse and affect the shape of the disc.

(Herranz et al., 2012)

Expression of Egfr^Scer\UAS.cBa enhances the rough eye phenotype seen when Dcp-1^Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4^GMR.PF.

(Kim et al., 2010)

Cardiac-specific expression of Egfr^Scer\UAS.cBa driven by Scer\GAL4^tin.CΔ4 in Df(3L)ED4238/+ mutants restores normal cardiac function.

(Yu et al., 2010)

Co-expression of hppy^RB.Scer\UAS suppresses the rough eye and blistering phenotypes caused by expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF.

(Corl et al., 2009)

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF results in a rough-eye phenotype, which is enhanced by the presence of Fas2^EB112/+.

(Mao and Freeman, 2009)

Co-expression of pico^IR.Scer\UAS suppresses the wing overgrowth seen when Egfr^Scer\UAS.cBa is expressed in the wing using Scer\GAL4^Bx-MS1096.

(Lyulcheva et al., 2008)

A heterozygous aux^I670K/+ background has no effect on the rough eye phenotype observed in Egfr^Scer\UAS.cBa;Scer\GAL4^GMR.PF mutants.

(Hagedorn et al., 2006)

Coexpression of vn^Scer\UAS.cSa and Egfr^Scer\UAS.cBa under the control of Scer\GAL4^bi-md653 results in an enhancement of the haltere-to-wing transformation see when either transgene is expressed alone. This is an enhancement rather than an additive effect as the capitellum of the haltere produces between 10 and 22 bristles in the double transgene-expressing flies vs 5 at the most in the single transgene flies.

Expression of Egfr^Scer\UAS.cBa results in an enhancement of the haltere-to-wing transformation of Ubx^lac1-GAL4/+ mutants as the capitellum of the halteres produce 40-45 wing margin-type bristles in Egfr^Scer\UAS.cBa; Ubx^lac1-GAL4/+ flies while there are only 4-7 bristles in Ubx^lac1-GAL4/+ flies. The halteres of Ubx^lac1-GAL4/+ flies expressing Egfr^Scer\UAS.cBa also show increased pigmentation compared to Ubx^lac1-GAL4/+ or wild-type flies. Coexpression of vn^Scer\UAS.cSa and Egfr^Scer\UAS.cBa in a Ubx^lac1-GAL4/+ background results in a further enhancement of the phenotype.

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^bi-md653 in an argos^unspecified/+ background results in an enhancement of the haltere-to-wing transformation seen when Egfr^Scer\UAS.cBa is expressed in a wild-type background. Scer\GAL4^bi-md653>Egfr^Scer\UAS.cBa; argos^unspecified/+ flies produce 9-12 wing margin-type bristles on the capitellum of the haltere compared to 3-5 bristles produced by Scer\GAL4^bi-md653>Egfr^Scer\UAS.cBa flies.

Expression of Egfr^Scer\UAS.cBa under the control of Scer\GAL4^bi-md653 in a Ubx¹/+ background results in a marginal enhancement of the wing-to-haltere transformations seen in Ubx¹/+ mutants, or flies expressing Egfr^Scer\UAS.cBa in a wild-type background.

(Pallavi et al., 2006)

Defective migration of border follicle cells in Cbl^F165 homozygous somatic clones is enhanced by Egfr^Scer\UAS.cBa with Scer\GAL4^slbo.2.6.

Migration of border follicle cells is normal in spri^6G1 homozygotes, or in flies carrying Egfr^Scer\UAS.cBa with Scer\GAL4^slbo.2.6, but significant defects in border cell migration, including some instances of complete failure of migration are seen in spri^6G1/spri^6G1 Egfr^Scer\UAS.cBa animals.

(Jekely et al., 2005)

Co-expression of ed^{ΔECD.Scer\UAS} and Egfr^Scer\UAS.cBa under the control of Scer\GAL4^sca-537.4 results in severe tufting of bristles on the notum.

(Escudero et al., 2003)

Co-expression of Egfr^Scer\UAS.cBa and foxo^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF does not rescue the eye phenotype seen in animals expressing foxo^Scer\UAS.cKa alone under the control of Scer\GAL4^GMR.PF (ommatidia and bristles are still missing) and the general disorganisation of the ommatidia seen in animals expressing Egfr^Scer\UAS.cBa alone under the control of Scer\GAL4^GMR.PF is also unaffected in the double mutant flies.

(Kramer et al., 2003)

Expression of both Cbl^Dv.Scer\UAS and Egfr^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF significantly enhances both the rough eye and extent of ectopic wing veins.

(Robertson et al., 2000)

Co-expression of Egfr^{DN.Scer\UAS.cBa}, Egfr^Scer\UAS.cBa and rho^Scer\UAS.cBa driven by Scer\GAL4^Bx-MS1096 fully restores the rho^Scer\UAS.cBa induced ectopic vein phenotype.

(Guichard et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Egfr^UAS.cBa/Scer\GAL4^Bx-MS1096 rescues Egfr^DN2.UAS

(Guichard et al., 2002)

Partially rescues

Scer\GAL4^twi.PG, Scer\GAL4^how-24B, Egfr^UAS.cBa partially rescues Egfr^DN.UAS.cBa