FlyBase Allele Report: Dmel\trol[EP1160]

General Information

Symbol

Dmel\trol^EP1160

Species

D. melanogaster

Name

FlyBase ID

FBal0217146

Feature type

allele

Associated gene

Dmel\trol

Associated Insertion(s)

P{EP}trol^EP1160

Carried in Construct

Also Known As

EP(1)1160, UAS-Perlecan

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}trol^EP1160

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:2,518,110..2,518,110 [-]

(Herranz et al., 2014, Cho et al., 2012, FlyBase Curators, 2008-, Yan and Lin, 2007, Voigt et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Voigt et al., 2002)

viable

(Voigt et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

trol^EP1160, Scer\GAL4^ap-md544 is an enhancer of hyperplasia phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Scer\GAL4^P52/trol^EP1160 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Other

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, trol^EP1160 has neoplasia phenotype

(Herranz et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^P52/trol^EP1160 is an enhancer of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of trol^EP1160 and Egfr^Scer\UAS.cBa in the wing disc under the control of Scer\GAL4^ap-md544 results in massive overgrowth and neoplastic transformation. Mutant epithelial cells intermingle with wild type mesenchymal cells.

(Herranz et al., 2014)

Co-expression of trol^EP1160 significantly enhances the commissural axon phenotype (failure to cross the midline) seen in embryos expressing Sema-1a^Scer\UAS.cYa under the control of Scer\GAL4^P52 in a Sema-1a^k13702 null background.

(Cho et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11007

P{EP}trol^EP1160 w¹¹¹⁸

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EP-trol

(Herranz et al., 2014)

trol^EP1160

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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