Dα-catenin, αCat, alpha-catenin, Dα-cat, a-cat
an essential physical linker, acting at the adherins junction, between the cadherin-β-catenin complex and the actin cytoskeleton - stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction
Please see the JBrowse view of Dmel\α-Cat for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Gene model reviewed during 5.45
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
3.4 (northern blot)
None of the polypeptides share 100% sequence identity.
935 (aa); 110 (kD observed)
Interacts with arm/armadillo protein.
Rapidly phosphorylated by CK2 and more slowly by CK1.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\α-Cat using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
In the cellular blastoderm embryo, α-Cat protein is detected at the cell-cell boundary of all cells. At stage 9, expression continues to be detected in all cells. At embryonic stage 11, expression is high in the ventral midline. At stage 16, expression is detected in many systems, including the epidermis, central nervous system, peripheral nervous system, and the guts. In the third instar larva, expression is detected at the interface of all epithelial cells in the leg disc. In the eye disc, expression is ubiquitous in the cell-cell boundary in the undifferentiated region in front of the morphogenetic furrow; in the differentiating region, α-Cat protein expression is highly concentrated in the photoreceptor clusters in the ommatidia.
Comment: very low expression in central brain unstructured neuropil ( adult subesophageal ganglion, adult deuterocerebrum, adult protocerebrum )
Comment: very low expression in central brain unstructured neuropil ( adult subesophageal ganglion, adult deuterocerebrum, adult protocerebrum )
Comment: very low expression in central brain unstructured neuropil ( adult subesophageal ganglion, adult deuterocerebrum, adult protocerebrum )
JBrowse - Visual display of RNA-Seq signals
View Dmel\α-Cat in JBrowse3-47
3-44.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Isolated from a genomic library, using a mouse αE-catenin cDNA as a probe, under low stringency conditions.
α-Cat has been cloned and sequenced, and its expression pattern has been analysed.
