FB2024_04 , released June 25, 2024
Allele: Dmel\AbiUAS.ΔEna
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General Information
Symbol
Dmel\AbiUAS.ΔEna
Species
D. melanogaster
Name
FlyBase ID
FBal0302621
Feature type
allele
Associated gene
Dmel\Abi
Associated Insertion(s)
Carried in Construct
M{UAS-Abi.ΔEna}
Key Links
Transgenic product class
inframe_deletion
(Chen et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Chen et al., 2014)
Mutagen
in vitro construct
(Chen et al., 2014)
Progenitor genotype
Carried in construct
M{UAS-Abi.ΔEna}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of Abi that lacks both ena binding motifs.

(Chen et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Abi
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AbiScer\UAS.ΔEna under the control of Scer\GAL4elav-C155 has no effect on photoreceptor axon targeting.

      The egg laid by flies expressing AbiScer\UAS.ΔEna under the control of Scer\GAL4da.PU in a AbiΔ20 mutant background are abnormally round compared to controls.

      (Chen et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      AbiUAS.ΔEna/Scer\GAL4da.PU partially rescues AbiΔ20

      (Chen et al., 2014)
      Fails to rescue

      Scer\GAL4elav-C155/AbiUAS.ΔEna fails to rescue AbiΔ20

      (Chen et al., 2014)
      Comments

      Expression of AbiScer\UAS.ΔEna under the control of Scer\GAL4da.PU does not fully rescue the morphology defects seen in AbiΔ20 mutant macrophages. The resulting macrophages are still less circular than controls (more spiky) and have a reduced rate of membrane protrusion. Expression of AbiScer\UAS.ΔEna under the control of Scer\GAL4elav-C155 does not rescue the axon targeting defects seen in the AbiΔ20 mutant optic lobe.

      (Chen et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AbiScer\UAS.ΔEna
      AbiUAS.ΔEna
      Name Synonyms
      Secondary FlyBase IDs
        References (1)