FlyBase Allele Report: Dmel\Abi[KO]

General Information

Symbol

Dmel\Abi^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0239157

Feature type

allele

Associated gene

Dmel\Abi

Associated Insertion(s)

TI{TI}Abi^KO

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Lin et al., 2009)

Mutagen

recombination

(Lin et al., 2009)

ends-out gene targeting

(Lin et al., 2009)

Progenitor genotype

Associated Insertion(s)

TI{TI}Abi^KO

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage (with Abi^P2)

(Lin et al., 2009)

lethal | recessive

(Lin et al., 2009)

lethal - all die before end of pupal stage (with Abi^P2)

(Lin et al., 2009)

lethal - all die before end of pupal stage (with Df(3R)JY19)

(Lin et al., 2009)

some die during pupal stage (with Abi^P2)

(Lin et al., 2009)

some die during pupal stage (with Df(3R)JY19)

(Lin et al., 2009)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

(Kannan et al., 2017)

larval longitudinal connective (with Abi^P2)

(Lin et al., 2009)

larval longitudinal connective (with Df(3R)JY19)

(Lin et al., 2009)

Detailed Description

Statement

Reference

Abi^KO heterozygous embryos display stalling of the ISNb motor nerve at the junction of muscles 6 and 13, with failure to innervate muscle 12 (observed in 31% of examined hemisegments).

(Kannan et al., 2017)

More than 60% of Abi^P1/Abi^KO animals survive to adulthood.

9.6% of Abi^KO/Abi^P2 and 31.25% of Abi^KO/Df(3R)JY19 embryos have midline crossing defects in ipsilateral axon fascicles at stage 17.

(Lin et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Abi^P2/Abi^KO has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by Abl⁴/Abl[+]

(Lin et al., 2009)

Df(3R)JY19/Abi^KO has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by Abl⁴/Abl[+]

(Lin et al., 2009)

Suppressor of

Statement

Reference

Abi[+]/Abi^KO is a suppressor | partially of lethal phenotype of Abl⁴/Abl¹

(Lin et al., 2009)

Abi[+]/Abi^KO is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Abl⁴/Abl¹

(Lin et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Abi^KO has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, enhanceable by SCAR^Δ37/SCAR[+]

(Kannan et al., 2017)

Suppressed by

Statement

Reference

Abi^P2/Abi^KO has larval longitudinal connective phenotype, suppressible | partially by Abl⁴/Abl[+]

(Lin et al., 2009)

Df(3R)JY19/Abi^KO has larval longitudinal connective phenotype, suppressible | partially by Abl⁴/Abl[+]

(Lin et al., 2009)

Enhancer of

Statement

Reference

Abi[+]/Abi^KO is an enhancer of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of SCAR^Δ37

(Kannan et al., 2017)

Suppressor of

Statement

Reference

Abi[+]/Abi^KO is a suppressor | partially of NMJ bouton | increased number phenotype of Abl⁴/Abl¹

(Lin et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

SCAR^Δ37/+;Abi^KO/+ double heterozygous embryos show stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 in 79% of examined hemisegments - a strongly increased penetrance compared to either of the single heterozygotes.

(Kannan et al., 2017)

The frequency of the midline crossing defect seen in Fas-expressing axons in Abi^KO/Df(3R)JY19 embryos is suppressed from 32% to 15% by Abl⁴/+.

The frequency of the midline crossing defect seen in Fas-expressing axons in Abi^KO/Abi^P2 embryos is suppressed from 9.6% to 3% by Abl⁴/+.

The increased bouton number per muscle area that is seen at the neuromuscular junction of Abl¹/Abl⁴ larvae is significantly suppressed by Abi^KO/+. This suppression further increased if the flies are also carrying ena^GC5/+.

(Lin et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Abi^KO

(Cheong et al., 2020)

abi^KO

(Kannan et al., 2017, Lin et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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