FB2024_04 , released June 25, 2024
Allele: Dmel\AbiUAS.cSa
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General Information
Symbol
Dmel\AbiUAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Stephan
FlyBase ID
FBal0269219
Feature type
allele
Associated gene
Dmel\Abi
Associated Insertion(s)
Carried in Construct
M{UAS-Abi.S}
Key Links
Transgenic product class
wild_type
(Stephan et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Stephan et al., 2011)
Mutagen
in vitro construct
(Stephan et al., 2011)
Progenitor genotype
Carried in construct
M{UAS-Abi.S}
Cytology
Description

UAS regulatory sequences drive expression of a full length Abi protein.

(Stephan et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Abi
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AbiScer\UAS.cSa under the control of Scer\GAL4elav-C155 has no effect on photoreceptor axon targeting.

      Flies expressing AbiScer\UAS.cSa under the control of Scer\GAL4da.PU in a AbiΔ20 mutant background show disruption to the integrity of cortical actin in nurse cells and the flies are completely sterile.

      Flies expressing AbiScer\UAS.cSa under the control of either Scer\GAL4da.PU alone or Scer\GAL4da.PU and Scer\GAL4mat.αTub67C.T:Hsim\VP16 in a AbiΔ20 mutant background results in egg morphology defects.

      Expression of AbiScer\UAS.cSa under the control of Scer\GAL4da.PU in a wild type background has no effect on fertility.

      (Chen et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/AbiUAS.cSa rescues AbiΔ20

      (Chen et al., 2014)

      AbiUAS.cSa/Scer\GAL4da.PU rescues AbiΔ20

      (Chen et al., 2014)

      Scer\GAL4elav-C155/AbiUAS.cSa rescues AbiΔ20

      (Stephan et al., 2011)

      AbiUAS.cSa/Scer\GAL4da.G32 rescues AbiΔ20

      (Stephan et al., 2011)
      Fails to rescue

      AbiUAS.cSa/Scer\GAL4GMR.PU fails to rescue AbiΔ20

      (Stephan et al., 2011)

      AbiUAS.cSa/Scer\GAL4repo fails to rescue AbiΔ20

      (Stephan et al., 2011)
      Comments

      Expression of AbiScer\UAS.cSa under the control of Scer\GAL4da.PU substantially rescues the morphology defects seen in AbiΔ20 mutant macrophages. The rescued cells exhibit stable and periodic membrane protrusions. The defects in photoreceptor axon targeting are rescued when AbiScer\UAS.cSa is expressed under the control of Scer\GAL4elav-C155.

      (Chen et al., 2014)

      Ubiquitous expression of AbiScer\UAS.cSa under the control of Scer\GAL4da.G32 rescues the lethality of the AbiΔ20 allele.

      Expression of AbiScer\UAS.cSa in the glial cells of AbiΔ20 mutants under the control of Scer\GAL4repo does not modulate the axon-bundle targeting defects in the larval visual system.

      Pan-neuronal expression of AbiScer\UAS.cSa under the control of Scer\GAL4elav-C155 in AbiΔ20 mutants completely restores the axonal projection pattern.

      Expression of AbiScer\UAS.cSa in the eye disk and R-cells under the control of Scer\GAL4GMR.PU does not rescue the axonal targeting defects in the larval visual system of AbiΔ20 mutants.

      (Stephan et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AbiScer\UAS.cSa
      AbiUAS.cSa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Stephan
      Secondary FlyBase IDs
        References (3)