FlyBase Allele Report: Dmel\Abi[P2]

General Information

Symbol

Dmel\Abi^P2

Species

D. melanogaster

Name

FlyBase ID

FBal0239155

Feature type

allele

Associated gene

Dmel\Abi

Associated Insertion(s)

P{EP}Abi^P2

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Lin et al., 2009)

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}Abi^P2

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage (with Abi^KO)

(Lin et al., 2009)

abnormal neuroanatomy | embryonic stage | maternal effect, with Df(3R)JY19/Abi^P1

(Lin et al., 2009)

lethal - all die before end of pupal stage (with Abi^KO)

(Lin et al., 2009)

lethal - all die before end of pupal stage (with Df(3R)JY19)

(Lin et al., 2009)

some die during pupal stage (with Abi^KO)

(Lin et al., 2009)

some die during pupal stage (with Df(3R)JY19)

(Lin et al., 2009)

Phenotype Manifest In

larval longitudinal connective (with Abi^KO)

(Lin et al., 2009)

larval longitudinal connective | maternal effect, with Df(3R)JY19/Abi^P1

(Lin et al., 2009)

Detailed Description

Statement

Reference

Embryos maternally hypomorphic for Abi function and lacking zygotic Abi function (derived from Abi^P1/Df(3R)JY19 females mated to Abi^P2 carrying males) have deranged longitudinal connectives and commissural tracts. 57.1% of these embryos have midline crossing defects in ipsilateral axon fascicles at stage 17.

9.6% of Abi^KO/Abi^P2 embryos have midline crossing defects in ipsilateral axon fascicles at stage 17.

(Lin et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Abi^P2/Abi^KO has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by Abl⁴/Abl[+]

(Lin et al., 2009)

Suppressor of

Statement

Reference

Abi[+]/Abi^P2 is a suppressor | partially of abnormal neuroanatomy | embryonic stage phenotype of Abl⁴/Abl¹

(Lin et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

Abi^P2/Abi^KO has larval longitudinal connective phenotype, suppressible | partially by Abl⁴/Abl[+]

(Lin et al., 2009)

Suppressor of

Statement

Reference

Abi[+]/Abi^P2 is a suppressor | partially of larval longitudinal connective phenotype of Abl⁴/Abl¹

(Lin et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of the midline crossing defect seen in Fas-expressing axons in Abl¹/Abl⁴ embryos is suppressed from 37% to 18% by Abi^P2/+.

The frequency of the midline crossing defect seen in Fas-expressing axons in Abi^KO/Abi^P2 embryos is suppressed from 9.6% to 3% by Abl⁴/+.

(Lin et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the insertion reverts the lethal phenotype.

(Lin et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Abi^P2

abi^P2

(Lin et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close