FB2024_02 , released April 23, 2024
Gene: Dmel\mir-ban
Open Close
General Information
Symbol
Dmel\mir-ban
Species
D. melanogaster
Name
bantam
Annotation Symbol
CR43018
Feature Type
miRNA_gene
FlyBase ID
FBgn0262451
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
a 21 nucleotide microRNA that promotes tissue growth, stimulates cell proliferation and prevents apoptosis - controls of type I and type II central brain neuroblast proliferation (Interactive Fly, mir-ban )
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ban, dme-bantam, EP3208, miR-bantam

Key Links
Genomic Location
Cytogenetic map
61C7-61C7
Sequence location
Recombination map
3-0.5
RefSeq locus
NT_037436 REGION:642208..642288
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (29 terms)
Molecular Function (2 terms)
Biological Process (27 terms)
Terms Based on Experimental Evidence (27 terms)
CV Term
Evidence
References
involved_in cellular response to X-ray
inferred from direct assay
(Bilak et al., 2014)
involved_in dendrite regeneration
inferred from mutant phenotype
(Song et al., 2012)
involved_in eye development
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Nolo et al., 2006)
involved_in formation of a compartment boundary
inferred from mutant phenotype
(Becam et al., 2011)
involved_in germ-line stem cell population maintenance
inferred from mutant phenotype
(Yang et al., 2009, Shcherbata et al., 2007)
involved_in miRNA-mediated gene silencing by inhibition of translation
inferred from direct assay
(Kertesz et al., 2007)
involved_in miRNA-mediated gene silencing by mRNA destabilization
inferred from direct assay
(Djuranovic et al., 2012, Kadener et al., 2009)
involved_in miRNA-mediated post-transcriptional gene silencing
inferred from direct assay
(Ito and Igaki, 2021, Gerlach et al., 2019, Wu et al., 2017, Herranz et al., 2012, Herranz et al., 2010, Orom et al., 2006, Robins et al., 2005, Brennecke et al., 2003)
inferred from mutant phenotype
(Orom et al., 2006)
involved_in negative regulation of apoptotic process
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Nolo et al., 2006)
inferred from mutant phenotype
(Brennecke et al., 2003)
inferred from genetic interaction with FLYBASE:hid; FB:FBgn0003997
(Brennecke et al., 2003)
involved_in negative regulation of apoptotic signaling pathway
inferred from mutant phenotype
(Bilak et al., 2014)
involved_in negative regulation of BMP signaling pathway
inferred from mutant phenotype
(Kane et al., 2018)
involved_in negative regulation of cellular senescence
inferred from mutant phenotype
(Ito and Igaki, 2021)
involved_in positive regulation of cell population proliferation
inferred from mutant phenotype
(Thompson and Cohen, 2006, Brennecke et al., 2003, Raisin et al., 2003)
involved_in positive regulation of cell proliferation involved in compound eye morphogenesis
inferred from mutant phenotype
(Peng et al., 2009)
involved_in positive regulation of developmental growth
inferred from mutant phenotype
(Gerlach et al., 2019)
involved_in positive regulation of epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Herranz et al., 2012)
involved_in positive regulation of growth
inferred from mutant phenotype
(Oh and Irvine, 2011)
involved_in positive regulation of multicellular organism growth
inferred from mutant phenotype
(Raisin et al., 2003)
involved_in positive regulation of neuroblast proliferation
inferred from mutant phenotype
(Wu et al., 2017)
involved_in positive regulation of Notch signaling pathway
inferred from mutant phenotype
(Wu et al., 2017)
involved_in positive regulation of stem cell proliferation
inferred from mutant phenotype
(Huang et al., 2014)
involved_in regulation of apoptotic process
inferred from direct assay
(Jaklevic et al., 2008)
involved_in regulation of apoptotic signaling pathway
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Nolo et al., 2006)
involved_in regulation of cell population proliferation
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Nolo et al., 2006)
involved_in regulation of circadian rhythm
inferred from mutant phenotype
(Kadener et al., 2009)
involved_in regulation of dendrite development
inferred from mutant phenotype
(Parrish et al., 2009)
involved_in regulation of multicellular organism growth
inferred from mutant phenotype
(Hipfner et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in miRNA-mediated post-transcriptional gene silencing
inferred from electronic annotation with Rfam:RF00727
(RNAcentral, 2018-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Pathway (FlyBase)
    Positive Regulators of EGFR Signaling Pathway -
    Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.
    Negative Regulators of BMP Signaling Pathway -
    Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
    Positive Regulators of Notch Signaling Pathway -
    The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
    Summary (Interactive Fly)

    a 21 nucleotide microRNA that promotes tissue growth, stimulates cell proliferation and prevents apoptosis - controls of type I and type II central brain neuroblast proliferation

    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    0

    Please see the JBrowse view of Dmel\mir-ban for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Experimentally Determined Structures
    Crossreferences
    Comments on Gene Model

    Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).

    Conserved: found throughout the Drosophila genus (FBrf0230987).

    Sequence Ontology: Class of Gene
    miRNA_gene
    (FlyBase Genome Annotators, 2010, Brennecke et al., 2003)
    nuclear_gene
    (FlyBase Genome Annotators, 2010, Brennecke et al., 2003)
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    mir-ban-RA
    FBtr0304469
    NR_048213
    23
    mir-ban-RB
    FBtr0472739
    23
    mir-ban-RM
    FBtr0304468
    NR_048212
    81
    Additional Transcript Data and Comments
    Reported size (kB)

    .021 (northern blot, sequence analysis)

    (Brennecke et al., 2003)
    Comments
    External Data
    Crossreferences
    miRBase - A searchable database of published miRNA sequences and annotation.
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-ban using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    NA

    Transcript Expression
    northern blot
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    embryonic stage -- adult stage
    organism
    (Brennecke et al., 2003)
    larval stage
    wing disc
    (Brennecke et al., 2003)
    brain | restricted
    (Brennecke et al., 2003)
    Additional Descriptive Data

    The ban microRNA is detected during all stages of development by northern analysis although level of expression varies with developmental stage. Expression is highest in 12-24 h embryos and 1st instar larvae. An assay employed a ubiquitously expressed GFP sensor protein whose transcript contained ban target sites and caused silencing of the reporter in the regions where ban microRNA is expressed. This assay indicates that ban microRNA is expressed throughout the wing disc but has the highest expression in areas of proliferation. A similar correlation between ban microRNA expression and cell proliferation was observed in the larval brain.

    (Brennecke et al., 2003)
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\mir-ban in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 26 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 16 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of mir-ban
    Transgenic constructs containing regulatory region of mir-ban
    Aberrations (Deficiencies and Duplications) ( 3 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    lethal, with Scer\GAL4Act5C.PU
    lethal, with Scer\GAL4Bx-MS1096
    lethal, with Scer\GAL4da.G32
    lethal, with Scer\GAL4ey.PH
    lethal, with Scer\GAL4ey.PU
    lethal - all die before end of P-stage, with Scer\GAL4Act5C.PI
    lethal - all die before end of P-stage, with Scer\GAL4sd-SG29.1
    lethal - all die before end of pupal stage
    lethal - all die before end of pupal stage, with Df(3L)mir-banΔ1, Scer\GAL4unspecified
    lethal - all die before end of pupal stage, with Scer\GAL4ptc-559.1
    lethal - all die before end of pupal stage (with Df(3L)emc-E12)
    partially lethal - majority die, with Scer\GAL4Tub.PU
    viable
    viable (with Df(3L)emc-E12)
    viable (with Df(3L)mir-banΔ1)
    Sterility
    Allele
    female semi-sterile
    female semi-sterile (with Df(3L)mir-banΔ1)
    female sterile (with Df(3L)mir-banΔ1)
    sterile
    sterile (with Df(3L)emc-E12)
    Other Phenotypes
    Allele
    abnormal locomotor rhythm, with Scer\GAL4P2.4.Pdf
    abnormal locomotor rhythm, with Scer\GAL4tim.PE
    abnormal neuroanatomy | larval stage, with Scer\GAL4arm.PS
    abnormal neuroanatomy | larval stage, with Scer\GAL4C855a
    abnormal neuroanatomy | larval stage, with Scer\GAL4elav-C155
    abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
    abnormal planar polarity | adult stage, with Scer\GAL4ey.PH
    abnormal size, with Scer\GAL4GMR.PF
    abnormal size | adult stage, with Scer\GAL4Bx-MS1096
    abnormal size | third instar larval stage, with Scer\GAL4ap-md544
    abnormal sleep | adult stage, with Hsap\RELAAD.R14C08, Scer\GAL4DBD.R15B01
    decreased body size
    decreased body size (with Df(3L)emc)
    decreased body size (with Df(3L)mir-banΔ1)
    decreased body size (with mir-banEP3622)
    decreased body size (with mir-banUY3207)
    decreased cell death, with Scer\GAL4GMR.PF
    decreased cell death | adult stage, with Scer\GAL4GMR.PF
    decreased cell number
    decreased cell number (with Df(3L)mir-banΔ1)
    decreased cell number (with mir-banEP3622)
    decreased cell number (with mir-banUY3207)
    decreased cell number | adult stage | somatic clone (with Df(3L)mir-banΔ1)
    decreased cell number | adult stage | somatic clone (with mir-banEP3622)
    decreased cell number | adult stage | somatic clone (with mir-banL1170a)
    decreased cell number | cell autonomous | oogenesis, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
    decreased cell number | cell non-autonomous, with Scer\GAL4en-e16E
    decreased cell number | larval stage | somatic clone (with Df(3L)mir-banΔ1)
    decreased cell number | larval stage | somatic clone (with mir-banEP3622)
    decreased cell number | larval stage | somatic clone (with mir-banL1170a)
    decreased cell number | pupal stage | somatic clone (with Df(3L)mir-banΔ1)
    decreased cell number | pupal stage | somatic clone (with mir-banEP3622)
    decreased cell number | pupal stage | somatic clone (with mir-banL1170a)
    decreased cell size, with Scer\GAL4ap-md544
    decreased cell size, with Scer\GAL4en-e16E
    decreased occurrence of cell division | larval stage, with Scer\GAL4dpp.blk1
    decreased sleep | adult stage, with Hsap\RELAAD.R14C08, Scer\GAL4DBD.R15B01
    decreased sleep | adult stage, with Scer\GAL4GMR14C08
    decreased sleep | adult stage, with Scer\GAL4nSyb.PP
    flightless | progressive, with Scer\GAL4Mef2.PU
    increased cell death
    increased cell death (with mir-banEP3622)
    increased cell death (with mir-banL1170a)
    increased cell number | adult stage, with Scer\GAL4GMR.PF
    increased cell number | cell autonomous, with Scer\GAL4en-e16E
    increased cell number | cell autonomous | oogenesis, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
    increased cell number | embryonic stage, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
    increased cell number | somatic clone, with Scer\GAL4FRT.Act5C
    increased cell number | third instar larval stage, with Scer\GAL4repo.PU
    increased cell size | larval stage, with Scer\GAL4insc-Mz1407
    increased cell size | somatic clone, with Scer\GAL4Act5C.PP
    increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
    increased occurrence of cell division | larval stage, with Scer\GAL4ptc-559.1
    increased occurrence of cell division | third instar larval stage, with Scer\GAL4sd-SG29.1
    increased sleep | adult stage, with Scer\GAL4nSyb.PP
    increased sleep | adult stage, with Scer\GAL4ple.PF
    neoplasia | larval stage, with Scer\GAL4en-e16E
    some die during pharate adult stage, with Scer\GAL4sd-SG29.1
    some die during P-stage, with Scer\GAL4Act5C.PI
    some die during pupal stage
    some die during pupal stage, with Df(3L)mir-banΔ1, Scer\GAL4unspecified
    some die during pupal stage, with Scer\GAL4ptc-559.1
    some die during pupal stage (with Df(3L)emc-E12)
    visible, with Scer\GAL4ap-md544
    visible, with Scer\GAL4Bx-MS1096
    visible, with Scer\GAL4en-e16E
    visible, with Scer\GAL4GMR.PF
    visible, with Scer\GAL4ptc-559.1
    visible, with Scer\GAL4sca-537.4
    visible, with Scer\GAL4sd-SG29.1
    Phenotype manifest in
    Allele
    1st posterior cell, with Scer\GAL4ptc-559.1
    adult midgut progenitor cell, with Scer\GAL4NP5130
    adult midgut progenitor cell | chemical conditional, with Scer\GAL4NP5130
    anterior fascicle & synapse, with Scer\GAL4elav-C155
    cell cycle, with Scer\GAL4ptc-559.1
    dendrite | larval stage, with Scer\GAL4arm.PS
    dorsal-ventral compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4sd-SG29.1
    dorsal-ventral compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4vg.int2.1
    embryonic/larval brain | third instar larval stage, with Scer\GAL4repo.PU
    embryonic/larval glial cell | third instar larval stage, with Scer\GAL4repo.PU
    embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Pxn.PS
    embryonic/larval optic lobe | larval stage, with Scer\GAL4C855a
    eye, with Scer\GAL4GMR.PF
    eye-antennal disc | larval stage, with Scer\GAL4dpp.blk1
    eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PI
    eye disc | third instar larval stage, with Scer\GAL4repo.PU
    female germline stem cell | adult stage | somatic clone (with Df(3L)mir-banΔ1)
    female germline stem cell | adult stage | somatic clone (with mir-banEP3622)
    female germline stem cell | adult stage | somatic clone (with mir-banL1170a)
    female germline stem cell | cell autonomous, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
    female germline stem cell | germline clone
    female germline stem cell | larval stage | somatic clone (with Df(3L)mir-banΔ1)
    female germline stem cell | larval stage | somatic clone (with mir-banEP3622)
    female germline stem cell | larval stage | somatic clone (with mir-banL1170a)
    female germline stem cell | pupal stage | somatic clone (with Df(3L)mir-banΔ1)
    female germline stem cell | pupal stage | somatic clone (with mir-banEP3622)
    female germline stem cell | pupal stage | somatic clone (with mir-banL1170a)
    fusome | larval stage (with Df(3L)emc-E12)
    germline cell | larval stage
    germline cell | larval stage (with Df(3L)emc-E12)
    germline stem cell (with Df(3L)emc-E12)
    indirect flight muscle cell, with Scer\GAL4Mef2.PU
    intermediate neuronal progenitor | larval stage, with Scer\GAL4insc-Mz1407
    interommatidial bristle | ectopic, with Scer\GAL4GMR.PF
    interommatidial bristle | increased number, with Scer\GAL4GMR.PF
    larva, with Scer\GAL4en-e16E
    larval intersegmental nerve, with Scer\GAL4elav-C155
    larval segment, with Scer\GAL4en-e16E
    mesothoracic tergum, with Scer\GAL4ap-md544
    microchaeta, with Scer\GAL4ap-md544
    nucleolus | larval stage, with Scer\GAL4insc-Mz1407
    ommatidium, with Scer\GAL4GMR.PF
    ommatidium | adult stage, with Scer\GAL4ey.PH
    pigment cell | increased number, with Scer\GAL4GMR.PF
    primordial germ cell | embryonic stage | increased number, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
    scutellar bristle | ectopic, with Scer\GAL4sca-537.4
    tormogen cell, with Scer\GAL4sca-537.4
    wing
    wing, with Scer\GAL4Bx-MS1096
    wing, with Scer\GAL4en-e16E
    wing, with Scer\GAL4sd-SG29.1
    wing (with Df(3L)emc)
    wing (with Df(3L)mir-banΔ1)
    wing (with mir-banEP3622)
    wing (with mir-banUY3207)
    wing | posterior, with Scer\GAL4en-e16E
    wing blade posterior compartment, with Scer\GAL4en-e16E
    wing disc | larval stage, with Scer\GAL4ptc-559.1
    wing disc | somatic clone, with Scer\GAL4FRT.Act5C
    wing disc dorsal compartment | third instar larval stage, with Scer\GAL4ap-md544
    wing disc posterior compartment | larval stage, with Scer\GAL4en-e16E
    wing vein, with Scer\GAL4Bx-MS1096
    wing vein L2, with Scer\GAL4sd-SG29.1
    wing vein L4, with Scer\GAL4sd-SG29.1
    wing vein L5, with Scer\GAL4sd-SG29.1
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (0)
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (0)
    Mus musculus (laboratory mouse) (0)
    Xenopus tropicalis (Western clawed frog) (0)
    Danio rerio (Zebrafish) (0)
    Caenorhabditis elegans (Nematode, roundworm) (0)
    Anopheles gambiae (African malaria mosquito) (0)
    Arabidopsis thaliana (thale-cress) (0)
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    Schizosaccharomyces pombe (Fission yeast) (0)
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:mir-ban. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Human Disease Associations
    FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    mir-banC.UAS.EGFP
    model of  carcinoma
    CEA with EgfrUAS.cBa
    (Herranz et al., 2012)
    model of  cancer
    CEA with Rab5LL00467
    (Cong et al., 2021)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 7 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    RNA-protein
    Physical Interaction
    Assay
    References
    mir-ban - AGO1
    anti bait coimmunoprecipitation, northern blot, anti tag coimmunoprecipitation, filter binding, competition binding, autoradiography, pull down, western blot, nuclease footprinting
    (Kakumani et al., 2020, Wen et al., 2015, Yang et al., 2014, Carré et al., 2013, Hur et al., 2013, Nishida et al., 2013, Eulalio et al., 2009, Flynt et al., 2009, Miyoshi et al., 2009, Eulalio et al., 2008, Zhou et al., 2008, Förstemann et al., 2007, Rehwinkel et al., 2006, Miyoshi et al., 2005, Okamura et al., 2004)
    mir-ban - AGO2
    anti tag coimmunoprecipitation, northern blot, filter binding, autoradiography
    (Yang et al., 2014, Hur et al., 2013, Rehwinkel et al., 2006, Okamura et al., 2004)
    mir-ban - Dcr-1
    enzymatic study, autoradiography, anti tag coimmunoprecipitation, northern blot, electrophoretic mobility shift assay
    (Liu et al., 2007, Ye et al., 2007, Saito et al., 2005)
    mir-ban - Fmr1
    anti bait coimmunoprecipitation, quantitative reverse transcription pcr, anti tag coimmunoprecipitation, northern blot
    (Yang et al., 2009, Okamura et al., 2004)
    mir-ban - His1
    anti tag coimmunoprecipitation, quantitative reverse transcription pcr
    (Liu et al., 2016)
    mir-ban - Ran
    anti tag coimmunoprecipitation, northern blot
    (Zhou et al., 2008)
    mir-ban - RpL21
    anti tag coimmunoprecipitation, northern blot
    (Zhou et al., 2008)
    mir-ban - RpL22
    anti tag coimmunoprecipitation, northern blot
    (Zhou et al., 2008)
    mir-ban - RpL32
    anti tag coimmunoprecipitation, northern blot
    (Zhou et al., 2008)
    mir-ban - RpS7
    anti tag coimmunoprecipitation, northern blot
    (Zhou et al., 2008)
    mir-ban - SmD1
    anti bait coimmunoprecipitation, primer specific pcr
    (Xiong et al., 2015)
    mir-ban - Unr
    pull down, western blot
    (Kakumani et al., 2020)
    mir-ban - bel
    anti tag coimmunoprecipitation, northern blot
    (Zhou et al., 2008)
    mir-ban - drosha
    enzymatic study, northern blot
    (Denli et al., 2004)
    mir-ban - gw
    anti tag coimmunoprecipitation, northern blot, anti bait coimmunoprecipitation
    (Eulalio et al., 2009, Eulalio et al., 2009, Miyoshi et al., 2009, Zekri et al., 2009)
    mir-ban - loqs
    anti bait coimmunoprecipitation, northern blot, fluorescence polarization spectroscopy, predetermined participant, anti tag coimmunoprecipitation
    (Tants et al., 2017, Miyoshi et al., 2009, Saito et al., 2005)
    mir-ban - pasha
    enzymatic study, northern blot
    (Denli et al., 2004)
    mir-ban - ref(2)P
    anti tag coimmunoprecipitation, quantitative reverse transcription pcr
    (Ghosh et al., 2024)
    mir-ban - vig
    anti tag coimmunoprecipitation, northern blot
    (Zhou et al., 2008)
    RNA-RNA
    Physical Interaction
    Assay
    References
    mir-ban - Clk
    luminiscence technology, necessary binding region
    (Kadener et al., 2009)
    mir-ban - Mad
    luminiscence technology, necessary binding region
    (Robins et al., 2005)
    mir-ban - Tgi
    immunohistochemistry, luminiscence technology, necessary binding region, western blot
    (Shen et al., 2015)
    mir-ban - cic
    luminiscence technology, necessary binding region
    (Herranz et al., 2012)
    mir-ban - hid
    luminiscence technology, immunohistochemistry, fluorescence technology, necessary binding region
    (Shen et al., 2015, Kertesz et al., 2007, Leaman et al., 2005, Robins et al., 2005, Brennecke et al., 2003)
    mir-ban - mei-P26
    luminiscence technology, necessary binding region, immunohistochemistry
    (Herranz et al., 2010)
    mir-ban - numb
    luminiscence technology, necessary binding region
    (Wu et al., 2017)
    mir-ban - trbl
    fluorescence technology
    (Gerlach et al., 2019)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    mir-ban
    enhanceable
    CycE
    (Nolo et al., 2006)
    mir-ban
    enhanceable
    Egfr
    (Herranz et al., 2012)
    mir-ban
    suppressible
    Myc
    (Wu et al., 2017, Reddy and Irvine, 2011)
    mir-ban
    suppressible
    Pi3K92E
    (Raisin et al., 2003)
    mir-ban
    suppressible
    shi
    (Hobin et al., 2022)
    mir-ban
    suppressible
    Socs36E
    (Herranz et al., 2012)
    mir-ban
    enhanceable
    Tie
    (Bilak et al., 2014)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    brk
    suppressible
    mir-ban
    (Oh and Irvine, 2011)
    Bub3
    suppressible
    mir-ban
    (Romão et al., 2021)
    bw
    suppressible
    mir-ban
    (Schneiderman et al., 2010)
    Dcr-1
    suppressible
    mir-ban
    (Herranz et al., 2010)
    dpn
    suppressible
    mir-ban
    (Wu et al., 2017)
    E2f1|Dp
    enhanceable
    mir-ban
    (Brennecke et al., 2003)
    Egfr
    enhanceable
    mir-ban
    (Herranz et al., 2012)
    ex
    suppressible
    mir-ban
    (Hipfner et al., 2002)
    hid
    suppressible
    mir-ban
    (Brennecke et al., 2003)
    hpo
    suppressible
    mir-ban
    (Nolo et al., 2006)
    N
    suppressible
    mir-ban
    (Ku and Sun, 2017, Wu et al., 2017, Huang et al., 2014, Becam et al., 2011)
    N
    enhanceable
    mir-ban
    (Wu et al., 2017)
    numb
    suppressible
    mir-ban
    (Wu et al., 2017)
    Ras85D|l(2)gl
    suppressible
    mir-ban
    (Ito and Igaki, 2021)
    Rbf
    enhanceable
    mir-ban
    (Tanaka-Matakatsu et al., 2009)
    rpr
    suppressible
    mir-ban
    (Brennecke et al., 2003)
    sav
    suppressible
    mir-ban
    (Huang et al., 2014)
    sisRNA:2
    suppressible
    mir-ban
    (Osman and Pek, 2021)
    Tie
    suppressible
    mir-ban
    (Bilak et al., 2014)
    yki
    suppressible
    mir-ban
    (Huang et al., 2014, Morrison and Halder, 2010, Neto-Silva et al., 2010, Nolo et al., 2006, Thompson and Cohen, 2006)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Positive Regulators of EGFR Signaling Pathway -
    Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.
    Negative Regulators of BMP Signaling Pathway -
    Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
    Positive Regulators of Notch Signaling Pathway -
    The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-0.5
    Cytogenetic map
    61C7-61C7
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    61C7-61C7
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    61C7-61C8
    (determined by in situ hybridisation)
    (Abdelilah-Seyfried et al., 2000)
    Experimentally Determined Recombination Data
    Location

    3-0.5

    (FlyBase, 2016)

    3-0.3

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (20)
    cDNA Clones (0)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 

                • New stable cell line derived from S2-unspecified : S2 cell lines were created that express EGFP mRNA containing target sites in the 3' UTR for either mir-1, mir-34, mir-let7, or mir-ban.

                  (Ameres et al., 2010)

                • New stable cell line derived from S2-unspecified : S2 cells stably expressing 3' UTRs from miRNA-targeted mRNAS attached to a Luciferase reporter were created. Two of the lines carry the hid 3' UTR with a wild type or mutated MRE (microRNA recognition element) for the miR-2 family. The other two carry the rpr 3' UTR with wild type or mutated MREs for mir-ban.

                  (Tat et al., 2016)
                Other Comments

                ban limits IR-induced apoptosis in larval imaginal discs.

                (Jaklevic et al., 2008)

                Upregulation of ban miRNA suppresses neurodegeneration.

                (Bilen et al., 2006)

                ban activity defines distinct targets that modulate neuro-degeneration.

                (Bilen et al., 2006)

                ban is a target of the hpo signalling pathway.

                (Nolo et al., 2006)

                ban suppresses W expression.

                (Nolo et al., 2006)

                ban mutant clones grow poorly due to a reduced rate of cell proliferation.

                (Thompson and Cohen, 2006)

                ban acts downstream of yki in the hpo pathway.

                (Thompson and Cohen, 2006)

                New annotation (CR33559) in release 4.1 of the genome annotation.

                (FlyBase Genome Annotators, 2005)

                ban microRNA simultaneously stimulates cell proliferating and prevent apoptosis.

                (Brennecke et al., 2003)
                Relationship to Other Genes
                Source for database merge of
                Additional comments

                The annotation for ban has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR33559 to CR43018 to reflect this change.

                (FlyBase Genome Annotators, 2010)

                " BEST:RE64518 " does not encode "ban" function.

                (Brennecke et al., 2003)

                Evidence suggests that the P{EP}EP3219EP3219 insertion is probably not an allele of "ban" but instead affects a genetically separable locus; the decrease in wing size seen in EP3219EP3219/Df(3L)banΔ1 flies is due primarily to a reduction in cell size rather than cell number, in contrast to banL1170a/Df(3L)banΔ1, banEP3622/Df(3L)banΔ1 or banEPg30491/Df(3L)banΔ1 flies, where the decrease in wing size is due to a reduction in the number of cells. In addition, EP3219EP3219 combined with banL1170a, banEPg30491 or banEP3622 has little or no effect on growth.

                (Hipfner et al., 2002)
                Nomenclature History
                Source for database identify of

                Source for identity of: ban EP3208

                (Hipfner et al., 2002)

                Source for identity of: mir-ban ban

                (FlyBase, 2009-)
                Nomenclature comments

                Added 'mir-' prefix to be consistent with miRNA naming conventions in FlyBase, and thereby indicate the gene encodes a miRNA in its symbol.

                (FlyBase, 2009-)
                Etymology

                The gene is named "bantam" after the mutant phenotype; mutant flies are smaller than normal.

                (Hipfner et al., 2002)
                Synonyms and Secondary IDs (17)
                Reported As
                Symbol Synonym
                Ban
                (Ghosh et al., 2024, Gou et al., 2020, Richardson and Portela, 2017, Yadav et al., 2016)
                Bantam
                (Picao-Osorio et al., 2017, Chan et al., 2011)
                CR33559
                (Schneiderman et al., 2010, FlyBase Genome Annotators, 2005)
                CR43018
                (FlyBase Genome Annotators, 2010)
                EP3208
                (Abdelilah-Seyfried et al., 2000)
                ban
                (Shi et al., 2023, Baonza et al., 2022, Ding et al., 2022, Enomoto and Igaki, 2022, Hobin et al., 2022, Kumar and Baker, 2022, Liu et al., 2022, Yang et al., 2022, Tokamov et al., 2021, Yin et al., 2021, Guo et al., 2020, Vissers et al., 2020, Grendler et al., 2019, Ma et al., 2019, Misra and Irvine, 2019, Moreno et al., 2019, Sun et al., 2019, Texada et al., 2019, Yee et al., 2019, Azuma et al., 2018, Cho et al., 2018, Setiawan et al., 2018, Volin et al., 2018, Yu and Pan, 2018, Jordán-Álvarez et al., 2017, Li et al., 2017, Ma et al., 2017, Moeller et al., 2017, Perry et al., 2017, Tants et al., 2017, Wu et al., 2017, Zhang et al., 2017, Huang et al., 2016, Pan et al., 2016, Zhang et al., 2016, Dong et al., 2015, Panneton et al., 2015, Wang and Baker, 2015, Xing et al., 2015, Zhang et al., 2015, Bassett et al., 2014, Bilak et al., 2014, Huang et al., 2014, Jiang et al., 2014, Robbins et al., 2014, Wang et al., 2014, Degoutin et al., 2013, Oh et al., 2013, Slattery et al., 2013, Smibert et al., 2013, Zhang and Lai, 2013, Djuranovic et al., 2012, Kagey et al., 2012, Matakatsu and Blair, 2012, Poon et al., 2012, Song et al., 2012, Tan et al., 2012, Genevet and Tapon, 2011, Muliyil et al., 2011, Oh and Irvine, 2011, Reddy and Irvine, 2011, Richter et al., 2011, Slattery et al., 2011, FlyBase Genome Annotators, 2010, Gehrke et al., 2010, Milton et al., 2010, Morrison and Halder, 2010, Neto-Silva et al., 2010, Robinson et al., 2010, Silicheva et al., 2010, Berry et al., 2009, Genevet et al., 2009, Parrish et al., 2009, Peng et al., 2009, Shen et al., 2009, Yang et al., 2009, Dutta and Baehrecke, 2008, Jaklevic et al., 2008, Okamura et al., 2008, Stofanko et al., 2008, Gibert et al., 2007, Kuzin et al., 2007, Shcherbata et al., 2007, Bilen et al., 2006, Bilen et al., 2006, Meyer et al., 2006, Thompson and Cohen, 2006, Leaman et al., 2005)
                bantam
                (Anna and Kannan, 2021, Bejarano and Lai, 2021, Besen-McNally et al., 2021, Dobens et al., 2021, Gogia et al., 2021, Coelho, 2020, Galagali and Kim, 2020, Gerlach and Herranz, 2020, La Marca and Richardson, 2020, Patke et al., 2020, Skouloudaki et al., 2020, Xia et al., 2020, Cosacak et al., 2018, Goodwin et al., 2018, Lin et al., 2018, Moon et al., 2018, Richardson and Portela, 2018, Simón-Carrasco et al., 2018, Chandra et al., 2017, Cottrell et al., 2017, Mendoza-Viveros et al., 2017, Harris et al., 2016, Jiang et al., 2016, Mohammed and Lai, 2016.2.8, Dong et al., 2015, Kohlmaier et al., 2015, Parker and Struhl, 2015, Xiong et al., 2015, Yang et al., 2014, Andersen et al., 2013, Enderle and McNeill, 2013, Hombría and Serras, 2013, Fausti et al., 2012, Liu et al., 2012, Raftery and Umulis, 2012, Laprise, 2011, Neubacher et al., 2011, Repiso et al., 2011, Zhao et al., 2011, Büssing et al., 2010, Okamura et al., 2009, Chan et al., 2005)
                bantam-3p
                (Seong et al., 2018)
                cot
                (Raisin et al., 2003)
                dme-bantam
                (Towler et al., 2015, miRBase, 2013, Berezikov et al., 2011)
                miR-ban
                (Aliyari et al., 2008)
                miR-bantam
                (Liu et al., 2016)
                mir-ban
                (Ascencio et al., 2023, Shcherbata, 2019, Snigdha et al., 2019, Yang and Chien, 2019)
                mir-bantam
                (Örkenby et al., 2023)
                Name Synonyms
                Bantam
                (Morin-Poulard et al., 2021, Zhang et al., 2021, Harris et al., 2016, Jaszczak and Halme, 2016, Tat et al., 2016, Ylla et al., 2016, Copf, 2015, Chen et al., 2014, Okamura et al., 2013, Zhang and Lai, 2013, Pushpavalli et al., 2012, Eulalio et al., 2009, Lv et al., 2009, Eulalio et al., 2008, Zhou et al., 2008, He and Hannon, 2004)
                bantam
                (Busseau et al., 2024, Chan et al., 2023, Kim et al., 2023, Böttcher et al., 2022, Yildirim et al., 2022, Bejarano et al., 2021, Cong et al., 2021, Ito and Igaki, 2021, Osman and Pek, 2021, Ai et al., 2020, Ford et al., 2020, Guo et al., 2020, Hao et al., 2020, Kakumani et al., 2020, Luo et al., 2020, Song and Zhou, 2020, van Soldt and Cardoso, 2020, Gerlach et al., 2019, Hanyu-Nakamura et al., 2019, Kobayashi et al., 2019, Liu et al., 2019, Liu et al., 2019, Reichholf et al., 2019, Wu et al., 2019, Alberti et al., 2018, Banerjee and Roy, 2018, Dubey and Tapadia, 2018, Osman and Pek, 2018, Xu et al., 2018, Banerjee and Roy, 2017, Banerjee and Roy, 2017, Li et al., 2017, Moeller et al., 2017, Qu et al., 2017, Shu et al., 2017, Song et al., 2017, Specchia et al., 2017, Barron and Moberg, 2016, Bonfini et al., 2016, Hu et al., 2016, Sharifkhodaei et al., 2016, Suijkerbuijk et al., 2016, Xiong et al., 2016, Fulga et al., 2015, Irvine and Harvey, 2015, Lerner et al., 2015, Meserve and Duronio, 2015, Pasco et al., 2015, Shen et al., 2015, Su, 2015, Suh et al., 2015, Tataroglu and Emery, 2015, Wen et al., 2015, Weng and Cohen, 2015, Barrio et al., 2014, Huang et al., 2014, Kozomara et al., 2014, Lam et al., 2014, Lee et al., 2014, Naqvi et al., 2014, Robbins et al., 2014, Wang et al., 2014, Carré et al., 2013, Coutinho-Budd and Freeman, 2013, Daneshvar et al., 2013, Degoutin et al., 2013, Doumpas et al., 2013, Huang et al., 2013, Hur et al., 2013, Jin et al., 2013, Lucas and Raikhel, 2013, McKay and Lieb, 2013, Nesler et al., 2013, Nishida et al., 2013, Slattery et al., 2013, Bejarano et al., 2012, Bejarano et al., 2012, Djuranovic et al., 2012, Helfer et al., 2012, Herranz et al., 2012, Herranz et al., 2012, Li and Padgett, 2012, Nagaraj et al., 2012, Schertel et al., 2012, Szuplewski et al., 2012, Tan et al., 2012, Vodala et al., 2012, Westholm et al., 2012, Becam et al., 2011, Enderle et al., 2011, Han et al., 2011, Hartig and Förstemann, 2011, Liu et al., 2011, Muliyil et al., 2011, Oh and Irvine, 2011, Qian et al., 2011, Reddy and Irvine, 2011, Sanders and Smith, 2011, Slattery et al., 2011, Smibert et al., 2011, Staiger and Koster, 2011, Ameres et al., 2010, Djuranovic et al., 2010, Flynt et al., 2010, Gehrke et al., 2010, Ghildiyal et al., 2010, Herranz et al., 2010, Milton et al., 2010, Morrison and Halder, 2010, Nayak et al., 2010, Robinson et al., 2010, Schneiderman et al., 2010, Schneiderman et al., 2010, Cziko et al., 2009, Eulalio et al., 2009, Flynt et al., 2009, Genevet et al., 2009, Hamaratoglu et al., 2009, Kadener et al., 2009, Kadener et al., 2009, Lee et al., 2009, Martin et al., 2009, Miyoshi et al., 2009, Nahvi et al., 2009, Parrish et al., 2009, Pek et al., 2009, Peng et al., 2009, Sabin et al., 2009, Shen et al., 2009, Tanaka-Matakatsu et al., 2009, Yang et al., 2009, Yu et al., 2009, Zekri et al., 2009, Berdnik et al., 2008, Berdnik et al., 2008, Czech et al., 2008, Dutta and Baehrecke, 2008, Herranz et al., 2008, Ibáñez-Ventoso et al., 2008, Jaklevic et al., 2008, Kawamura et al., 2008, Neumuller et al., 2008, Okamura et al., 2008, Okamura et al., 2008, Reynolds et al., 2008, Semeshin et al., 2008, Shah and Förstemann, 2008, Shcherbata et al., 2008, Stofanko et al., 2008, Zhang et al., 2008, Easow et al., 2007, Förstemann et al., 2007, Garcia et al., 2007, Horwich et al., 2007, Kertesz et al., 2007, Liu et al., 2007, Neumüller et al., 2007, Nurminsky, 2007, Park et al., 2007, Reynolds, 2007, Ruby et al., 2007, Shcherbata et al., 2007, Shcherbata et al., 2007, Ye et al., 2007, Barbee et al., 2006, Bilen et al., 2006, Cho et al., 2006, Nolo et al., 2006, Orom et al., 2006, Rehwinkel et al., 2006, Thompson and Cohen, 2006, Vagin et al., 2006, Burgler and Macdonald, 2005, Stark et al., 2005, Trotta et al., 2005, Okamura et al., 2004, Rehmsmeier et al., 2004, Enright et al., 2003, Hipfner et al., 2002)
                clochette
                (Raisin et al., 2003)
                dme-bantam
                (He et al., 2022, Lucas et al., 2015, Esslinger et al., 2013)
                mIR-bantam
                (Zhou et al., 2009)
                miR-bantam
                (Czech et al., 2009)
                pri-bantam
                (Eulalio et al., 2007)
                Secondary FlyBase IDs
                • FBgn0064191
                • FBgn0043352
                • FBgn0262311
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 26 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms
                Other crossreferences
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                miRBase - A searchable database of published miRNA sequences and annotation.
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                References (407)