FB2024_02 , released April 23, 2024
FB2024_02 , released April 23, 2024
CV Term Report
Help Close All Open All
General Information
Term miRNA-mediated gene silencing by mRNA destabilization ID (Ontology) GO:0035279 (Gene Ontology)
Definition An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.[ PubMed:14744438 PubMed:15196554 PubMed:21118121 PubMed:23209154 ]
Also Known As "gene silencing by miRNA, mRNA cleavage" ; "miRNA-mediated gene silencing, mRNA cleavage" ; "mRNA cleavage involved in gene silencing by microRNA" (for all, see Synonyms field below)
Comment
Links to Extrernal Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      22
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 miRNA-mediated gene silencing by mRNA destabilization (all annotations which use CV term, excluding "NOT" statements)      22
     involved_in | miRNA-mediated gene silencing by mRNA destabilization      22
Spanning Tree (Parents/Children)
Only view relationship: 
regulatory ncRNA-mediated post-transcriptional gene silencing
 |__miRNA-mediated post-transcriptional gene silencing__
regulation of mRNA stability                            |
 |__mRNA destabilization________________________________|
RNA destabilization                                     |
 |__mRNA destabilization________________________________|
positive regulation of mRNA catabolic process           |
 |__mRNA destabilization________________________________|
                                                        miRNA-mediated gene silencing by mRNA destabilization  22 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a miRNA-mediated post-transcriptional gene silencing
mRNA destabilization
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "deadenylation involved in gene silencing by miRNA" RELATED
    "gene silencing by miRNA, mRNA cleavage" EXACT
    "gene silencing by mRNA cleavage" BROAD
    "miRNA-mediated gene silencing by mRNA deadenylation" RELATED
    "miRNA-mediated gene silencing, mRNA cleavage" EXACT
    "mRNA cleavage involved in gene silencing by microRNA" EXACT
    "mRNA cleavage involved in gene silencing by miRNA" EXACT
    "mRNA deadenylation-mediated gene silencing by miRNA" RELATED
    "mRNA destabilization-mediated gene silencing by miRNA" EXACT
Secondary IDs
hide External Crossreferences & Linkouts