FlyBase Gene Report: Dmel\mir-let7

General Information

Symbol

Dmel\mir-let7

Species

D. melanogaster

Name

let7

Annotation Symbol

CR42949

Feature Type

miRNA_gene

FlyBase ID

FBgn0262406

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

encodes an RNA species involved in translational silencing of target mRNAs - let-7-to-miR-125 miRNA switch regulates neuronal integrity and lifespan in Drosophila (Interactive Fly, mir-let7 )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Interactive Fly

Also Known As

dme-let-7

Key Links

Genomic Location

Cytogenetic map

36F5-36F5

Sequence location

2L:18,472,034..18,472,111 [+]

Recombination map

2-53

RefSeq locus

NT_033779 REGION:18472034..18472111

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables mRNA 3'-UTR binding

inferred from direct assay

(Gehrke et al., 2010, Burgler and Macdonald, 2005)

enables mRNA base-pairing translational repressor activity

inferred from direct assay

(Chawla et al., 2016, Chen et al., 2014, Toledano et al., 2012, Wu et al., 2012, Gehrke et al., 2010, Burgler and Macdonald, 2005)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (12 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

involved_in cellular response to ecdysone

inferred from genetic interaction with FLYBASE:usp; FB:FBgn0003964

(Chen et al., 2014)

inferred from genetic interaction with FLYBASE:EcR; FB:FBgn0000546

(Kucherenko et al., 2012)

inferred from mutant phenotype

(Chawla and Sokol, 2012)

acts_upstream_of_positive_effect determination of adult lifespan

inferred from mutant phenotype

(Chawla et al., 2016)

acts_upstream_of_negative_effect germ-line stem-cell niche homeostasis

inferred from mutant phenotype

(Toledano et al., 2012)

involved_in metamorphosis

inferred from expression pattern

(Sempere et al., 2002)

involved_in miRNA-mediated gene silencing by inhibition of translation

inferred from direct assay

(Wakiyama et al., 2007)

involved_in miRNA-mediated gene silencing by mRNA destabilization

inferred from mutant phenotype

(Wakiyama et al., 2007)

inferred from direct assay

(Toledano et al., 2012, Wu et al., 2012)

inferred from mutant phenotype

(Chawla et al., 2016)

involved_in miRNA-mediated post-transcriptional gene silencing

inferred from direct assay

(Chen et al., 2014, Gehrke et al., 2010, Burgler and Macdonald, 2005)

involved_in mushroom body development

inferred from mutant phenotype

(Kucherenko et al., 2012)

involved_in negative regulation of gene expression

inferred from mutant phenotype

(Kucherenko et al., 2012)

involved_in negative regulation of receptor signaling pathway via JAK-STAT

inferred from mutant phenotype

(Toledano et al., 2012)

involved_in regulation of circadian rhythm

inferred from mutant phenotype

(Chen et al., 2014)

involved_in regulation of development, heterochronic

inferred from mutant phenotype

(Caygill and Johnston, 2008, Sokol et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in miRNA-mediated post-transcriptional gene silencing

inferred from electronic annotation with Rfam:RF00027

(RNAcentral, 2018-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of RISC complex

inferred from electronic annotation with Rfam:RF00027

(RNAcentral, 2018-)

Gene Group (FlyBase)

Pathway (FlyBase)

Negative Regulators of JAK-STAT Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

Negative Regulators of JAK-STAT Signaling Pathway -: Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.

Summary (Interactive Fly)

encodes an RNA species involved in translational silencing of target mRNAs - let-7-to-miR-125 miRNA switch regulates neuronal integrity and lifespan in Drosophila

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mir-let7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).

Conserved: found throughout the Drosophila genus (FBrf0230987).

Sequence Ontology: Class of Gene

miRNA_gene

(FlyBase Genome Annotators, 2010, Lagos-Quintana et al., 2001)

nuclear_gene

(FlyBase Genome Annotators, 2010, Lagos-Quintana et al., 2001)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

FBtr0304324

FBtr0472746

FBtr0304323

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

miRBase - A searchable database of published miRNA sequences and annotation.

MI0000416

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-let7 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female & oogenesis

escort cell

(König and Shcherbata, 2015)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

late third instar larval stage -- pupal stage P7

central nervous system

Comment: 102h AEL - 36h APF

(Wu et al., 2012)

adult stage | male

organism

Comment: levels increase with age

(Chawla et al., 2016)

adult stage | female

organism

Comment: levels increase with age

(Chawla et al., 2016)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

organism

Comment: levels increase with age

(Chawla et al., 2016)

adult stage | female

organism

Comment: levels increase with age

(Chawla et al., 2016)

Additional Descriptive Data

let-7-miRNA is detected in increasing quantities during larval to pupal transition.

(Wu et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: TI{GAL4}lncRNA:let7C

Stage

Tissue/Position (including subcellular localization)

Reference

pharate adult stage P8

calyx of adult mushroom body | restricted

Comment: 48h APF

(Kucherenko et al., 2012)

pharate adult stage P13

calyx of adult mushroom body | restricted

Comment: 80h APF

(Kucherenko et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mir-let7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mir-let7

View exonic expression by tissue for Dmel\mir-let7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

12798012/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262406

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262406

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 20 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mir-let7

Transgenic constructs containing regulatory region of mir-let7

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)let-7-C^KO1

(Sokol et al., 2008)

Df(2L)let-7-C^KO2

(Wu et al., 2012)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PU

mir-let7^UAS.cSa

lethal, with Scer\GAL4^Bx-MS1096

lethal, with Scer\GAL4^ey.PU

mir-let7^UAS.cSa

lethal - all die before end of larval stage, with Scer\GAL4^ptc-559.1

mir-let7^{UAS.DsRed(Unk)}

lethal - all die before end of pupal stage, with Scer\GAL4^sd-SG29.1

mir-let7^UAS.pLUC

viable, with Scer\GAL4^Tub.PU

mir-let7^{sponge.V2.UAS.mCherry}

Other Phenotypes

Allele

abnormal locomotor behavior | recessive

mir-let7^Δ.cSa

abnormal memory, with Df(2L)let-7-C^GKI/Df(2L)let-7-C^KO1, mir-100^+tSa, mir-125^+tSa

mir-let7^Δ.cSa

abnormal neuroanatomy, with Df(2L)let-7-C^GKI/Df(2L)let-7-C^KO1, mir-100^+tSa, mir-125^+tSa

mir-let7^Δ.cSa

abnormal neuroanatomy | recessive

mir-let7^Δ.cSa

long lived | female | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

mir-let7^UAS.cCa

short lived | female | RU486 conditional, with Scer\GAL4^{Tub.Switch.PU}

mir-let7^UAS.cCa

short lived | male | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

mir-let7^UAS.cCa

some die during larval stage, with Scer\GAL4^ptc-559.1

mir-let7^{UAS.DsRed(Unk)}

some die during pupal stage, with Scer\GAL4^sd-SG29.1

mir-let7^UAS.pLUC

visible, with Scer\GAL4^Bx-MS1096

mir-let7^{UAS.DsRed(Unk)}

visible, with Scer\GAL4^vg.PM

mir-let7^UAS.cCa

Phenotype manifest in

Allele

adult mushroom body beta-lobe, with Df(2L)let-7-C^GKI/Df(2L)let-7-C^KO1, mir-100^+tSa, mir-125^+tSa

mir-let7^Δ.cSa

dopaminergic neuron

mir-let7^Δ.cSa

egg chamber, with Scer\GAL4^da.G32

mir-let7^UAS.pLUC

lobe system of adult mushroom body, with Df(2L)let-7-C^GKI/Df(2L)let-7-C^KO1, mir-100^+tSa, mir-125^+tSa

mir-let7^Δ.cSa

wing, with Scer\GAL4^vg.PM

mir-let7^UAS.cCa

wing disc, with Scer\GAL4^vg.PM

mir-let7^UAS.cCa

wing disc | somatic clone, with Scer\GAL4^Act.PU

mir-let7^UAS.cCa

wing vein L5, with Scer\GAL4^Bx-MS1096

mir-let7^{UAS.DsRed(Unk)}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\MIRLET7D

1 of 14

Yes

Hsap\MIRLET7G

1 of 14

Yes

Hsap\MIRLET7I

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Mirlet7d

1 of 14

Yes

Rnor\Mirlet7f1

1 of 14

Yes

Rnor\Mirlet7g

1 of 14

Yes

Rnor\Mirlet7i

1 of 14

Yes

Mus musculus (laboratory mouse) (3)

Mmus\Mirlet7d

1 of 14

Yes

Mmus\Mirlet7g

1 of 14

Yes

Mmus\Mirlet7i

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (4)

Drer\mirlet7a-5

1 of 14

Yes

Drer\mirlet7a-6

1 of 14

Yes

Drer\mirlet7i

1 of 14

Yes

Drer\mirlet7j

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mir-let7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, modulation by steroid hormone via mir-let7

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

mir-let7^UAS.cCa

ameliorates cancer

modeled by ph-d⁵⁰⁵, ph-p⁵⁰⁵

(Jiang et al., 2018)

ameliorates brain cancer

modeled by brat^KK113206

(Jiang et al., 2018)

mir-let7^UAS.cGa

ameliorates Parkinson's disease

modeled by Lrrk^I1915T.UAS

(Gehrke et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

mir-let7 - AGO1

anti bait coimmunoprecipitation, northern blot, nucleic acid uv cross-linking assay, autoradiography, pull down, western blot, molecular weight estimation by staining

(Kakumani et al., 2020, Lim et al., 2020, Lim et al., 2018, Ameres et al., 2011, Tomari et al., 2007)

mir-let7 - Dcr-1

enzymatic study, autoradiography, electrophoretic mobility shift assay, competition binding

(Pandey et al., 2022, Tsutsumi et al., 2011, Liu et al., 2007, Ye et al., 2007, Jiang et al., 2005)

mir-let7 - Fmr1

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Yang et al., 2009)

mir-let7 - Hen1

enzymatic study, autoradiography

(Mickute et al., 2018)

mir-let7 - Unr

pull down, western blot

(Kakumani et al., 2020)

mir-let7 - drosha

enzymatic study, autoradiography

(Pandey et al., 2022)

RNA-RNA

Physical Interaction

Assay

References

mir-let7 - Dp

luminiscence technology, necessary binding region, western blot

(Gehrke et al., 2010)

mir-let7 - Imp

fluorescence technology, necessary binding region, immunohistochemistry

(Toledano et al., 2012)

mir-let7 - ab

luminiscence technology, immunohistochemistry

(Kucherenko et al., 2012, Burgler and Macdonald, 2005)

mir-let7 - cwo

luminiscence technology, necessary binding region, quantitative reverse transcription pcr

(Chen et al., 2014)

mir-let7 - wech

luminiscence technology, necessary binding region

(Wakiyama et al., 2007)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mir-let7|mir-125

suppressible

(Caygill and Johnston, 2008)

mir-let7

suppressible

(Gehrke et al., 2010)

mir-let7

suppressible

E2f1

(Gehrke et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

EcR

suppressible

mir-let7

(Kucherenko et al., 2012)

Lrrk

suppressible

mir-let7

(Gehrke et al., 2010)

usp

suppressible

mir-let7

(Kucherenko et al., 2012)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262406

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of JAK-STAT Signaling Pathway -: Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-53

Cytogenetic map

36F5-36F5

Sequence location

2L:18,472,034..18,472,111 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36F5-36F5

Limits computationally determined from genome sequence between P{lacW}Aac11^k06710 and P{EP}CG10413^EP2164

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-53

(FlyBase, 2016)

2-53.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41171

w¹¹¹⁸; P{UAS-LUC-mir-let7.T}attP2

92825

w^*; sna^Sco/CyO; P{UAS-let7C}3

61365

w^*; P{UAS-mCherry.mir-let7.sponge.V2}attP40; P{UAS-mCherry.mir-let7.sponge.V2}attP2/TM6B, Tb¹

FlyORF

F001975

M{UAS-mir-let7.S}ZH-86Fb

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : S2 cell lines were created that express EGFP mRNA containing target sites in the 3' UTR for either mir-1, mir-34, mir-let7, or mir-ban.
(Ameres et al., 2010)

Other Comments

let-7 is required to regulate the timing of the α'/β' to α/β neuronal identity transition in the developing mushroom body, by targeting the ab transcription factor.

(Kucherenko et al., 2012)

let-7 is required to ensure the appropriate remodeling of the abdominal neuromusculature during the larval-to-adult transition.

(Sokol et al., 2008)

A long primary transcript comprising all the hairpin precursor sequences for mir-100, let-7 and mir-125 has been detected by RT-PCR. Overall orientation not stated: mir-100+ let-7+ mir-125+

(Aravin et al., 2003)

let-7 and mir-125 appear to be expressed from a common precursor RNA.

(Bashirullah et al., 2003)

mir-100, mir-125 and let-7 sequences are clustered within 800bp in 36E5--36F2.

(Sempere et al., 2003)

New annotation (CR32968) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Hormone induced expression of let-7 may control developmental stage transitions.

(Sempere et al., 2002)

A developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let-7 small temporal RNA (stRNA).

(Hutvagner et al., 2001)

Relationship to Other Genes

Source for database merge of

Additional comments

The annotation for let-7 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR32968 to CR42949 to reflect this change.

(FlyBase Genome Annotators, 2010)

The three microRNAs let-7, mir-125 and mir-100 are co-transcribed as a single polycistronic transcription unit (the "let-7-Complex, let-7-C").

(Sokol et al., 2008)

Nomenclature History

Source for database identify of

Source for identity of: mir-let7 let-7

(FlyBase, 2009-)

Nomenclature comments

Added 'mir-' prefix to be consistent with miRNA naming conventions in FlyBase, and thereby indicate the gene encodes a miRNA in its symbol.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CR32968

CR42949

(FlyBase Genome Annotators, 2010)

Let-7

(Chandra et al., 2017, Ylla et al., 2016, Tan et al., 2012, Yang et al., 2009, Jing et al., 2005)

dme-let-7

(He et al., 2022, Alberti et al., 2018, Volin et al., 2018, Dhahbi et al., 2016, Lucas et al., 2015, Towler et al., 2015, Mohammed et al., 2014, Esslinger et al., 2013, miRBase, 2013, Reinhardt et al., 2012, Berezikov et al., 2011, Ryazansky et al., 2011, O'Farrell et al., 2008, Huang and Gu, 2007)

let-7

(Bernard et al., 2024, Chan et al., 2023, Keith, 2023, Liu et al., 2023, Liu et al., 2022, Lu and Chtarbanova, 2022, Yildirim et al., 2022, Anna and Kannan, 2021, Bejarano et al., 2021, Goodwin and Hobert, 2021, Huang et al., 2021, Pandey et al., 2021, Sood et al., 2021, Galagali and Kim, 2020, Jin et al., 2020, Kakumani et al., 2020, Kinser and Pincus, 2020, Lim et al., 2020, Patke et al., 2020, Song and Zhou, 2020, Herrera and Bach, 2019, Lee et al., 2019, Liu et al., 2019, Liu et al., 2019, Sreejith et al., 2019, Daniel et al., 2018, Goodwin et al., 2018, Mickute et al., 2018, Tsuboyama et al., 2018, Ueda et al., 2018, Xue and Zhang, 2018, Busto et al., 2017, Doe, 2017, Gendron and Pletcher, 2017, He et al., 2017, Kreher et al., 2017, Mendoza-Viveros et al., 2017, Niinuma and Tomari, 2017, Picao-Osorio et al., 2017, Shu et al., 2017, Chawla et al., 2016, Faunes and Larraín, 2016, Ma et al., 2016, Mohammed and Lai, 2016.2.8, Xiong et al., 2016, Yasugi and Nishimura, 2016, Chen et al., 2015, Dorn and Dorn, 2015, Fulga et al., 2015, Iwasaki et al., 2015, Liang et al., 2015, Suh et al., 2015, Van Bortle et al., 2015, Abe et al., 2014, Chawla and Sokol, 2014, Chen et al., 2014, Chen et al., 2014, Fagegaltier et al., 2014, Kong et al., 2014, Kozomara et al., 2014, Mohammed et al., 2014, Shlyueva et al., 2014, Sorourian et al., 2014, Stratoulias et al., 2014, Wang et al., 2014, Xia and Zhang, 2014, Yeh et al., 2014, Gomes et al., 2013, Lucas and Raikhel, 2013, Mezan et al., 2013, Nesler et al., 2013, Pancratov et al., 2013, Bejarano et al., 2012, Bejarano et al., 2012, Chawla and Sokol, 2012, Fukunaga et al., 2012, Kucherenko et al., 2012, Matunis et al., 2012, Schertel et al., 2012, Tan et al., 2012, Toledano et al., 2012, Toledano et al., 2012, Westholm et al., 2012, Wu et al., 2012, Ameres et al., 2011, Behura et al., 2011, Cenik et al., 2011, Gerbasi et al., 2011, Han et al., 2011, Liu et al., 2011, Patraquim et al., 2011, Tsutsumi et al., 2011, Ameres et al., 2010, Fernandez-Valverde et al., 2010, FlyBase Genome Annotators, 2010, Garbuzov and Tatar, 2010, Gehrke et al., 2010, Gerbasi et al., 2010, Iwasaki et al., 2010, Miyoshi et al., 2010, Moretti et al., 2010, Czech et al., 2009, Iwasaki et al., 2009, Kawamata et al., 2009, Miyoshi et al., 2009, Yu et al., 2009, Caygill and Johnston, 2008, Caygill and Johnston, 2008, Ibáñez-Ventoso et al., 2008, O'Farrell et al., 2008, Sokol et al., 2008, Sokol et al., 2008, Stark et al., 2008, Behura, 2007, Caygill and Johnston, 2007, Förstemann et al., 2007, Liu et al., 2007, Ruby et al., 2007, Ruby et al., 2007, Ruby et al., 2007, Tomari et al., 2007, Wakiyama et al., 2007, Ye et al., 2007, Plasterk, 2006, Burgler and Macdonald, 2005, Stark et al., 2005, Haley and Zamore, 2004, Lau et al., 2001)

let-7-3p

(Gartland et al., 2022)

let-7-5p

(Lim et al., 2018)

let-7-C

(Luhur et al., 2014)

let7

(Shafer and Keene, 2021, Sinigaglia et al., 2019, Jiang et al., 2018, König and Shcherbata, 2015, Tataroglu and Emery, 2015, Bejarano et al., 2012, Neumuller et al., 2008)

let7-5p

(Fast et al., 2017)

miR-let-7

(Atilano et al., 2017)

mir-let7

(Jouravleva et al., 2022, Pandey et al., 2022, Sapar and Han, 2019, Shcherbata, 2019, Swevers, 2019, Yoshinari et al., 2019)

Name Synonyms

let-7

let7

Secondary FlyBase IDs

FBgn0260473
FBgn0043885
FBgn0262242

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 15 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

12798012

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms

Other crossreferences

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

12798012/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262406

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262406

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CR42949

MARRVEL_MODEL - MARRVEL (model organism gene)

12798012

miRBase - A searchable database of published miRNA sequences and annotation.

MI0000416

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262406

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0262406

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (224)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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