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General Information
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| Term |
alpha/beta Kenyon cell |
ID (Ontology) |
FBbt:00100248 (Fly Anatomy) |
| Definition |
Mushroom body neuron that bifurcates at the anterior end of the pedunculus and projects into the alpha and beta lobes of the adult mushroom body (Lee et al., 1999). The alpha/beta neurons are the last born of the Kenyon cells, generated during the pupal stage (Lee et al., 1999). In the pedunculus, the alpha/beta neurons occupy the core stratum with the alpha'/beta' neurons in the intermediate stratum and the gamma neurons at the periphery (Tanaka et al., 2008; Li et al., 2020). They are cholinergic neurons (Pankova & Borst, 2017) and they express sNPF (Johard et al., 2008; Barnstedt et al., 2016; Croset et al., 2018). There are around 900-1000 of these cells per hemisphere (Aso et al., 2014; Li et al., 2020).[ FlyBase:FBrf0111409 FlyBase:FBrf0202832 FlyBase:FBrf0205263 FlyBase:FBrf0231313 FlyBase:FBrf0235353 FlyBase:FBrf0238777 FlyBase:FBrf0248215 ] |
| Also Known As |
"alpha/beta KC" ; "alpha/beta neuron" ; "KCab" (for all, see Synonyms field below) |
| Comment |
Neuron was assessed to be cholinergic by Pankova & Borst (2017), based on anti-HA antibody detection of HA-tagged VAChT expression; Barnstedt et al. (2016) show that Kenyon cells express ChAT and VAChT proteins, and that antagonism of nicotinic ACh receptors or reduction of ACh processing in Kenyon cells impairs Kenyon cell-evoked responses in mushroom body output neurons. |
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Links to Extrernal Ontologies
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VFB:FBbt_00100248
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Alleles (FBal) | PHENOTYPE_MANIFEST_IN | 37 | | Insertions (FBti) | EXPRESSION_STAGE_TISSUE_POSITION | 45 | | Insertions (FBti) | PHENOTYPE_MANIFEST_IN | 6 | | Constructs (FBtp) | PHENOTYPE_MANIFEST_IN | 12 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Alleles | | Genes | Insertions | Constructs |
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alpha/beta Kenyon cell (all annotations which use CV term, excluding "NOT" statements) | 40 | 3 | 6 | 51 | 26 | alpha/beta Kenyon cell | adult stage | 14 | -- | -- | 1 | 10 | alpha/beta Kenyon cell | adult stage | cell non-autonomous | somatic clone | 1 | -- | -- | -- | -- | alpha/beta Kenyon cell | adult stage | somatic clone | 1 | -- | -- | -- | -- | alpha/beta Kenyon cell | larval stage | 2 | -- | -- | 1 | -- | alpha/beta Kenyon cell | somatic clone | 7 | -- | -- | -- | -- |
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Relationships