FB2024_02 , released April 23, 2024
FB2024_02 , released April 23, 2024
CV Term Report
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General Information
Term miRNA-mediated post-transcriptional gene silencing ID (Ontology) GO:0035195 (Gene Ontology)
Definition A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.[ PubMed:14744438 PubMed:15066275 PubMed:15066283 PubMed:23209154 PubMed:23985560 PubMed:28379604 ]
Also Known As "gene silencing by microRNA" ; "gene silencing by miRNA" ; "microRNA-mediated gene silencing"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     151
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Relevant FlyBase reports
 Gene Groups Genes
 miRNA-mediated post-transcriptional gene silencing (all annotations which use CV term, excluding "NOT" statements)       1    151
     involved_in | miRNA-mediated post-transcriptional gene silencing       --     151
 NOT | involved_in | miRNA-mediated post-transcriptional gene silencing       --       7
Spanning Tree (Parents/Children)
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post-transcriptional gene silencing_______
regulatory ncRNA-mediated gene silencing__|
                                          regulatory ncRNA-mediated post-transcriptional gene silencing
                                           |__miRNA-mediated post-transcriptional gene silencing  160 rec.
                                               |__miRNA-mediated gene silencing by inhibition of translation 15 rec.
                                               |__miRNA-mediated gene silencing by mRNA destabilization 22 rec.
                                               |__pre-miRNA export from nucleus
                                               |__regulation of miRNA-mediated gene silencing 5 rec.
                                                   |__negative regulation of miRNA-mediated gene silencing(+) 2 rec.
                                                   |__positive regulation of miRNA-mediated gene silencing(+) 2 rec.
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Is a regulatory ncRNA-mediated post-transcriptional gene silencing
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Synonyms
  • "gene silencing by microRNA" EXACT
    "gene silencing by miRNA" EXACT
    "microRNA-mediated gene silencing" EXACT
    "miRNA-mediated gene silencing" BROAD
Secondary IDs
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