FB2024_03 , released April 23, 2024
Allele: Dmel\Rab5LL00467
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General Information
Symbol
Dmel\Rab5LL00467
Species
D. melanogaster
Name
FlyBase ID
FBal0370892
Feature type
allele
Associated gene
Dmel\Rab5
Associated Insertion(s)
PBac{SAstopDsRed}LL00467
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{SAstopDsRed}LL00467
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{SAstopDsRed}
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  cancer
        CEA with mir-banC.UAS.EGFP
        (Cong et al., 2021)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Clones both homozygous for Rab5LL00467 and expressing mir-banC.UAS.EGFP under the control of Scer\GAL4Act5C.PI form tumors in the larval brain (which metastasize to the ventral nerve cord). Larval eye/antennal disc clones also form tumors and their induction leads to lethality. Co-expression of JhI-21HMS02271 suppresses tumorigenesis and lethality, but adults exhibit an eye phenotype.

        (Cong et al., 2021)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Rab5LL00467
        rab5LL00467
        (Cong et al., 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)