FlyBase Aberration Report: Dmel\Df(3L)emc-E12

General Information

Symbol

Df(3L)emc-E12

Species

D. melanogaster

Name

FlyBase ID

FBab0002367

Feature type

chromosomal_deletion

Also Known As

Df(3L)emc^E12, Df(3)emc^E12, emc^E12, Df(3L)emcE12

Computed Breakpoints include

61A;61D3

Features within 61A--61D3

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Isaac and Andrew, 1996, Pauli et al., 1995)

Breakpoints

61A;61D3-61D4

(Pauli et al., 1995)

61A;61D3

(Isaac and Andrew, 1996)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << fwd << emc << bk2

Genetic mapping information

Comments

Comments on Cytology

Deletes approximately 10 chromosomal bands, including the emc locus.

(Cubas et al., 1994)

Limits of break 1 from polytene analysis (FBrf0080317) Left limit of break 2 from polytene analysis (FBrf0080317) Right limit of break 2 from polytene analysis (FBrf0085269)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

emc

(Szeged Stock Center, 1998-)

fwd

(Brill et al., 2000)

Gale

(Sanders et al., 2010)

klar

(Mosley-Bishop et al., 1999, Welte et al., 1998)

l(3)S041919

(Szeged Stock Center, 1998-)

mir-ban

(Yang et al., 2009)

topiary

(Ghabrial et al., 2011)

trh

(Isaac and Andrew, 1996)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Cep290

(Basiri et al., 2014)

fang

(Myat et al., 2005)

gloin

(Myat et al., 2005)

Gyc76C

(Myat et al., 2005)

trio

(Brumby et al., 2004, Liebl et al., 2000)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

The salivary gland distal tip does not initiate turning and migration in embryos homozygous for Df(3L)emc-E12 by stage 14.

(Jattani et al., 2009)

Df(3L)emc-E12 embryos show defects in tracheal invagination.

(Myat et al., 2005)

The Df(3L)emc-E12 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(3L)emc-E12 results in 0.7% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

The size of the salivary gland lumen is reduced in homozygous embryos.

(Myat and Andrew, 2002)

Wild-type clones made in the ovaries of a mutant female, are significantly larger than clones of heterozygous mutant cells. This size difference is greater in clones initiated at 48 hours after egg laying (AEL) than 2 hours AEL.

(Extavour and Garcia-Bellido, 2001)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Homozygotes are embryonic lethal. emc¹/Df(3L)emc-E12 clones in the wing show defects in cell proliferation but overall wing size is not affected due to compensation by growth of surrounding non-mutant cells. Clones are very elongated and preferentially appear along the veins and wing margin. Clones can differentiate veins but exhibit an emc phenotype.

(de Celis et al., 1995)

Stocks (2)

Bloomington

2577

Df(3L)emc-E12/TM6B, Tb¹ ca¹

Kyoto

107406

Df(3L)emc-E12/TM6B, Tb¹ ca¹

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Def(2L)emc-E12

(Mukhopadhyay et al., 2002)

Df(3)emc^E12

(Mosley-Bishop et al., 1999, Brand et al., 1993, Martinez et al., 1993)

Df(3L)H2

(Isaac and Andrew, 1996)

Df(3L)emc-E12

(Das et al., 2016, Cuykendall et al., 2014, Galindo et al., 2014, Ghabrial et al., 2011, Sanders et al., 2010, Jattani et al., 2009, Yang et al., 2009, Crest et al., 2007, Saito et al., 2002)

Df(3L)emc^E12

(Gaspar et al., 2014, Kim et al., 2013, Yu et al., 2011, Kracklauer et al., 2007, Donaldson et al., 2004, Fischer et al., 2004, Patterson et al., 2004, Myat and Andrew, 2002, Baonza et al., 2000, Brill et al., 2000, Welte et al., 1998, de Celis et al., 1995, Cubas and Modolell, 1992)

Df(3L)emcE12

(Extavour and Garcia-Bellido, 2001, Pauli et al., 1995)

emc-E12

(Basiri et al., 2014)

emc^E12

(Cubas et al., 1994, Cubas and Modolell, 1992)

Name Synonyms

Secondary FlyBase IDs

References (58)

Report Sections

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