FlyBase Gene Report: Dmel\Gale

General Information

Symbol

Dmel\Gale

Species

D. melanogaster

Name

UDP-galactose 4'-epimerase

Annotation Symbol

CG12030

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035147

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

UDP-glucose 4-epimerase (5.1.3.2)

UDP-N-acetylglucosamine 4-epimerase (5.1.3.7)

Gene Summary

UDP-galactose 4'-epimerase (Gale) encodes an enzyme that contributes to galactose catabolism and larval lymph gland hemopoiesis. It epimerizes UDP-glucose to UDP-galactose and UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dGALE

Key Links

Genomic Location

Cytogenetic map

61C8-61C8

Sequence location

3L:648,555..651,311 [+]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:648555..651311

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables UDP-glucose 4-epimerase activity

inferred from mutant phenotype

(Daenzer et al., 2012, Sanders et al., 2010)

enables UDP-N-acetylglucosamine 4-epimerase activity

inferred from mutant phenotype

(Daenzer et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables UDP-glucose 4-epimerase activity

inferred from electronic annotation with InterPro:IPR005886

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000041817

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in galactose catabolic process via UDP-galactose

inferred from mutant phenotype

(Daenzer et al., 2012, Sanders et al., 2010)

involved_in larval lymph gland hemopoiesis

inferred from mutant phenotype

(Mondal et al., 2014)

involved_in UDP-D-galactose metabolic process

inferred from mutant phenotype

(Sanders et al., 2010)

involved_in UDP-glucose metabolic process

inferred from mutant phenotype

(Sanders et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in galactose catabolic process via UDP-galactose

inferred from biological aspect of ancestor with PANTHER:PTN000041817

(GO Reference Genome Project, 2011-)

involved_in galactose metabolic process

inferred from electronic annotation with InterPro:IPR005886

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000041817

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RACEMASES AND EPIMERASES ACTING ON CARBOHYDRATES AND DERIVATIVES

Protein Family (UniProt)

Belongs to the NAD(P)-dependent epimerase/dehydratase family. (Q9W0P5)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

UDP-N-acetylglucosamine 4-epimerase activity

UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine (5.1.3.7)

RHEA 20517: UDP-glucose 4-epimerase activity

UDP-alpha-D-glucose = UDP-alpha-D-galactose (5.1.3.2)

RHEA 22168:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RACEMASES AND EPIMERASES ACTING ON CARBOHYDRATES AND DERIVATIVES -: Racemases and epimerases acting on carbohydrates and derivatives invert the stereochemical arrangement at one or more chiral centers in a carbohydrate molecule. (Adapted from FBrf0238665.)

Protein Function (UniProtKB)

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine (PubMed:20519568, PubMed:22654673). The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited (PubMed:22654673). Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.

(UniProt, Q9W0P5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gale for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0P5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gale-RA

FBtr0072556

NM_138200

1757

350

Gale-RB

FBtr0306917

NM_001259608

1538

350

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gale-PA

FBpp0072455

38.7

350

7.52

FBpp0297771

38.7

350

7.52

Q9W0P5

NP_001246537

AFH04208

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

350 aa isoforms: Gale-PA, Gale-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homodimer.

(UniProt, Q9W0P5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gale using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.32

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

apoptotic amnioserosa

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval pericardial cell

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gale in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gale

View exonic expression by tissue for Dmel\Gale

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035147

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38076/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035147

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035147

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035147

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12030

Flygut - An atlas of the Drosophila adult midgut

FBgn0035147

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Gale

Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gale

Transgenic constructs containing regulatory region of Gale

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3L)ED4196

(Sanders et al., 2010)

Df(3L)emc-E12

(Sanders et al., 2010)

Df(3L)Exel6085

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

Gale^NIG.12030R

lethal, with Scer\GAL4^Act5C.PI, Scer\GAL80^ts.αTub84B

Gale^NIG.12030R

lethal, with Scer\GAL4^da.G32

Gale^GD7464

lethal, with Scer\GAL4^drm.7.1

Gale^NIG.12030R

lethal (with Df(3L)ED4196)

lethal (with Df(3L)emc-E12)

lethal (with Gale^f00624)

lethal (with Gale^h)

lethal (with Gale^Δy)

lethal | germline clone | late embryonic stage (with Gale^f00624)

Gale^Δy

lethal | germline clone | late embryonic stage (with Gale^Δy)

Gale^f00624

lethal | heat sensitive, with Scer\GAL4^Act5C.PI, Scer\GAL80^ts.αTub84B

Gale^NIG.12030R

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Gale^GD7464

lethal | recessive

lethal | second instar larval stage (with Gale^f00624)

Gale^Δy

lethal | second instar larval stage (with Gale^Δy)

Gale^f00624

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Gale^GD7464

viable

viable, with Scer\GAL4^Mef2.PR

Gale^GD7464

viable, with Scer\GAL4^tin.CΔ4

Gale^GD7464

Sterility

Allele

sterile, with Scer\GAL4^Act5C.PI, Scer\GAL80^ts.αTub84B

Gale^NIG.12030R

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Gale^GD7464

abnormal locomotor behavior | larval stage, with Scer\GAL4^how-24B

Gale^GD7464

abnormal neuroanatomy | larval stage

Gale^h

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

Gale^GD7464

abnormal neurophysiology | larval stage

Gale^h

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gale^GD7464

chemical sensitive

Gale^h

decreased body size | larval stage (with Gale^f00624)

Gale^Δy

decreased body size | larval stage (with Gale^Δy)

Gale^f00624

decreased fecundity | female | heat sensitive, with Scer\GAL4^Act5C.PI, Scer\GAL80^ts.αTub84B

Gale^NIG.12030R

short lived, with Scer\GAL4^Act5C.PI, Scer\GAL80^ts.αTub84B

Gale^NIG.12030R

short lived | chemical conditional, with Scer\GAL4^Act5C.PI

Gale^NIG.12030R

uncoordinated | larval stage

Gale^h

uncoordinated | larval stage, with Scer\GAL4^elav.PU

Gale^GD7464

Phenotype manifest in

Allele

embryonic/larval lymph gland, with Scer\GAL4^HCH.Hand, Scer\GAL4^Hml.Δ

Gale^NIG.12030R

embryonic/larval neuromuscular junction | larval stage

Gale^h

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Gale^GD7464

NMJ bouton | larval stage

Gale^h

NMJ bouton | larval stage, with Scer\GAL4^elav.PU

Gale^GD7464

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\GALE

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Gale

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (18)

Mmus\Gale

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\gale

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (14)

Drer\gale

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\gale-1

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP012261

12 of 12

Yes

Agam\AgaP_AGAP008664

6 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (51)

Atha\RHD1

12 of 13

Yes

Atha\UGE2

12 of 13

Yes

Atha\UGE5

12 of 13

Yes

Atha\UGE1

11 of 13

Yes

Atha\UGE3

11 of 13

Yes

Atha\AT4G20460

4 of 13

Yes

Atha\DUR

4 of 13

Yes

Atha\MEE25

4 of 13

Yes

Atha\MUR4

4 of 13

Yes

Atha\GAE1

3 of 13

Yes

Atha\GAE2

3 of 13

Yes

Atha\GAE3

3 of 13

Yes

Atha\GAE4

3 of 13

Yes

Atha\GAE5

3 of 13

Yes

Atha\GAE6

3 of 13

Yes

Atha\GME

2 of 13

Atha\SQD1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CRL1

1 of 13

Atha\CSP41A

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\GAL10

8 of 13

Yes

Scer\ERG26

1 of 13

Scer\YHR210C

1 of 13

Scer\YNR071C

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\uge1

12 of 12

Yes

Spom\gal10

8 of 12

Yes

Spom\SPBC3F6.02c

1 of 12

Spom\SPBPB2B2.11

1 of 12

Yes

Escherichia coli (enterobacterium) (5)

Ecol\galE

9 of 11

Yes

Ecol\fcl

1 of 11

Ecol\rfbB

1 of 11

Yes

Ecol\rffG

1 of 11

Yes

Ecol\ybjS

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gale. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

CG7724

1 of 13

Galm2

1 of 13

Gmd

1 of 13

Gmer

1 of 13

Tdh

1 of 13

Uxs

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

galactose epimerase deficiency

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

Gale^GD7464

model of galactosemia

CEA

(Jumbo-Lucioni et al., 2016)

Gale^Δy

model of galactosemia

CEA with Gale^NIG.12030R

(Daenzer et al., 2012)

Gale^h

model of galactosemia

CEA

(Jumbo-Lucioni et al., 2016, Sanders et al., 2010)

Gale^NIG.12030R

model of galactosemia

CEA

(Sanders et al., 2010)

CEA with Gale^Δy

(Daenzer et al., 2012)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GALE; UDP-galactose-4-epimerase

model of galactose epimerase deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Gale^GD7464

model of galactosemia

is exacerbated by Galt^Δ1AP2

(Jumbo-Lucioni et al., 2016)

Gale^h

exacerbates galactosemia

modeled by Galt^Δ1AP2

(Jumbo-Lucioni et al., 2016)

model of galactosemia

is exacerbated by Galt^Δ1AP2

(Jumbo-Lucioni et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GALE; UDP-galactose-4-epimerase

13 of 14

606953

GALACTOSEMIA III; GALAC3

galactose epimerase deficiency

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Gale

Ecol\galE

(Daenzer et al., 2012)

Gale

Hsap\GALE

(Daenzer et al., 2012, Sanders et al., 2010)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

MIST Molecular Interaction Search Tool

View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Gale - Ack

anti tag coimmunoprecipitation, peptide massfingerprinting

(Schoenherr et al., 2012)

Gale - Aldh

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Arf1

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Arl8

experimental knowledge based

(Guruharsha et al., 2011)

Gale - CCT6

experimental knowledge based

(Guruharsha et al., 2011)

Gale - CG13220

experimental knowledge based

(Guruharsha et al., 2011)

Gale - CG1416

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Chc

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Dp1

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Kap-α3

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Ldh

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Mcad

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Nfs1

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Rab1

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Rab2

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Rdh1

experimental knowledge based

(Guruharsha et al., 2011)

Gale - Rpt1

experimental knowledge based

(Guruharsha et al., 2011)

Gale - S6k

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Gale - ScsβG

experimental knowledge based

(Guruharsha et al., 2011)

Gale - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

Gale - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Gale - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Gale - spidey

experimental knowledge based

(Guruharsha et al., 2011)

Gale - wal

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Gale

enhanceable

Galt

(Jumbo-Lucioni et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Galt

enhanceable

Gale

(Jumbo-Lucioni et al., 2016)

External Data

Subunit Structure (UniProtKB)

Homodimer.

(UniProt, Q9W0P5 )

Linkouts

BioGRID - A database of protein and genetic interactions.

63631

DroID - A comprehensive database of gene and protein interactions.

FBgn0035147

MIST (protein-protein) - An integrated Molecular Interaction Database

38076

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Galactose catabolism

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Galactose catabolism

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

61C8-61C8

Sequence location

3L:648,555..651,311 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61C8-61C8

Limits computationally determined from genome sequence between P{PZ}l(3)05967⁰⁵⁹⁶⁷ and P{PZ}l(3)02640⁰²⁶⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-0.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

37739

w^*; Gale^h

22544

y¹ w^67c23; P{EPgy2}Gale^EY22205

37738

w^*; wg^Sp-1/CyO; Gale^Δy/TM6B, Tb¹

76977

y¹ sc^* v¹ sev²¹; P{TKO.GS00726}attP40

44496

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02429}attP2

FlyORF

F002803

M{UAS-Gale.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

HMC02429

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02429}attP2

VDRC

v106750

P{KK107540}VIE-260B

v47408

w¹¹¹⁸; P{GD7464}v47408

v318683

PBac{fTRG00833.sfGFP-TVPTBF}VK00002

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (101)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD27852

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035147

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035147

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Gale CG12030

(Sanders et al., 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Name Synonyms

UDP-gal 4' epimerase

(Kushner et al., 2010)

UDP-galactose 4'-epimerase

(Lee et al., 2014)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38076

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0P5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W0P5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0P5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035147

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38076/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035147

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035147

FlyMine - An integrated database for Drosophila genomics

FBgn0035147

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12030

MARRVEL_MODEL - MARRVEL (model organism gene)

38076

Linkouts

BioGRID - A database of protein and genetic interactions.

63631

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035147

DroID - A comprehensive database of gene and protein interactions.

FBgn0035147

DRSC - Results frm RNAi screens

FBgn0035147

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035147

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035147

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12030

Flygut - An atlas of the Drosophila adult midgut

FBgn0035147

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0035147

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009598

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

38076

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Galactose catabolism

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Galactose catabolism

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

-0.32

Report Sections