FB2024_03 , released June 25, 2024
Allele: Dmel\Galef00624
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General Information
Symbol
Dmel\Galef00624
Species
D. melanogaster
Name
FlyBase ID
FBal0187550
Feature type
allele
Associated gene
Dmel\Gale
Associated Insertion(s)
PBac{WH}Galef00624
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Sanders et al., 2010)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Galef00624
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Some zygotic GaleΔy/Galef00624 animals die as embryos, whereas others survive to first-second larval instar stages. Surviving L1 and L2 larvae are abnormally small and lethargic.

      GaleΔy/Galef00624 zygotic animals derived from Galef00624 germline clones die uniformly in late embryogenesis displaying no morphological defects.

      Galef00624/+ animals derived from Galef00624 germline clones are viable and eclose as healthy, fertile adults.

      (Sanders et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\GALEScer\UAS.cSa using either Scer\GAL4arm.PS or Scer\GAL4Act5C.PI rescues the lethality of GaleΔy/Galef00624 animals. Rescued animals are viable, fertile, and appear morphologically normal.

      Expression of Hsap\GALEScer\UAS.cSa using Scer\GAL4drm.7.1 partially rescues the lethality of GaleΔy/Galef00624 animals, whereas use of Scer\GAL4elav-C155 or Scer\GAL4c754 is completely insufficient to rescue or delay lethality of this genotype.

      (Sanders et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG12030f00624
      Galef00624
      dGALEf00624.4
      (Daenzer et al., 2012)
      dGALEf00624
      (Sanders et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)