PI4KIIIβ
a Golgi-localized lipid kinase, the homologue of phosphatidylinositol 4-kinase IIIβ which mediates the phosphorylation of phosphatidylinositol to generate phosphatidylinositol 4-phosphate, involved in spermatocyte cytokinesis and male fertility, mutants exhibit profound locomotor deficits and shortened lifespan
Please see the JBrowse view of Dmel\fwd for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Stop-codon suppression (UGA) postulated; FBrf0234051.
Gene model reviewed during 6.25
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fwd using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\fwd in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Area matching Drosophila EST AI297362.
fwd is required for intercellular bridge formation during cytokinesis in male meiosis.
Mutations of fwd affect the morphology and behaviour of the mitotic spindles of embryonic cleavage divisions to produce multipolar spindles in male meiosis and generate abnormal mitotic figures in larval neuroblasts.
Source for merge of: fwd CG7004
Source for merge of: fwd anon-WO0118547.259
Source for merge of fwd anon-WO0118547.259 was sequence comparison ( date:051113 ).