FlyBase Gene Report: Dmel\nonC

General Information

Symbol

Dmel\nonC

Species

D. melanogaster

Name

no-on-and-no-off transient C

Annotation Symbol

CG32743

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263968

Gene Model Status

Current

Stock Availability

15 publicly available

Enzyme Name (EC)

non-specific serine/threonine protein kinase (2.7.11.1)

Gene Summary

no-on-and-no-off transient C (nonC) encodes a phosphatidylinositol 3-kinase-related kinase. It functions in the nonsense-mediated mRNA decay (NMD) pathway by phosphorylation of the core NMD regulator encoded by Upf1. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Smg1, rst(1a)cyr, Smg

Key Links

Genomic Location

Cytogenetic map

6D3-6D4

Sequence location

X:6,824,496..6,838,122 [+]

Recombination map

1-18

RefSeq locus

NC_004354 REGION:6824496..6838122

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein serine/threonine kinase activity

inferred from electronic annotation with InterPro:IPR031559, InterPro:IPR039414

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000124197

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:Q96Q15

(Gene Ontology Curators, 2002-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in neuromuscular synaptic transmission

inferred from direct assay

(Long et al., 2010)

involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

inferred from mutant phenotype

(Rehwinkel et al., 2005, Gatfield et al., 2003)

inferred from mutant phenotype

(Avery et al., 2011, Rehwinkel et al., 2005)

inferred from direct assay

(Long et al., 2010)

involved_in synapse organization

inferred from direct assay

(Long et al., 2010)

involved_in synaptic vesicle transport

inferred from direct assay

(Long et al., 2010)

NOT involved_in miRNA-mediated post-transcriptional gene silencing

inferred from mutant phenotype

(Rehwinkel et al., 2005)

NOT involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

inferred from mutant phenotype

(Chen et al., 2005)

NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing

inferred from mutant phenotype

(Rehwinkel et al., 2005)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in DNA damage response

inferred from sequence or structural similarity with UniProtKB:Q96Q15

(Gene Ontology Curators, 2002-)

involved_in negative regulation of macroautophagy

inferred from biological aspect of ancestor with PANTHER:PTN000124327

(GO Reference Genome Project, 2011-)

involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

inferred from electronic annotation with InterPro:IPR031559, InterPro:IPR039414

(InterPro Project Members, 2004-)

involved_in peptidyl-serine phosphorylation

inferred from sequence or structural similarity with UniProtKB:Q96Q15

(Gene Ontology Curators, 2002-)

involved_in protein autophosphorylation

inferred from sequence or structural similarity with UniProtKB:Q96Q15

(Gene Ontology Curators, 2002-)

involved_in TOR signaling

inferred from biological aspect of ancestor with PANTHER:PTN000124327

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000124327

(GO Reference Genome Project, 2011-)

located_in cytoplasm

inferred from sequence or structural similarity with UniProtKB:Q96Q15

(Gene Ontology Curators, 2002-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000124197

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:Q96Q15

(Gene Ontology Curators, 2002-)

part_of TORC1 complex

inferred from biological aspect of ancestor with PANTHER:PTN000124327

(GO Reference Genome Project, 2011-)

part_of TORC2 complex

inferred from biological aspect of ancestor with PANTHER:PTN000124327

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ATYPICAL PROTEIN KINASES

Protein Family (UniProt)

Belongs to the PI3/PI4-kinase family. (Q70PP2)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine kinase activity

(1) ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] (2.7.11.1)

(2) ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl- [protein] (2.7.11.1)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ATYPICAL PROTEIN KINASES -: Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.

Protein Function (UniProtKB)

Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence

(UniProt, Q70PP2)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

nonC (J.C. Hall)

Defective phototaxis and optomotor responses; no light-on or light-off transients in electroretinogram, probably due to defect in photoreceptor cells per se; abnormal orientation to spots in Y-maze test.

Summary (Interactive Fly)

a regulatory kinase of the nonsense-mediated decay pwathway - acts to regulate proper mRNA translation to safeguard synapse morphology and maintain the efficacy of synaptic function

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\nonC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q70PP2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

nonC-RA

FBtr0070972

NM_167095

10039

3218

nonC-RB

FBtr0343321

NM_001298038

10621

3218

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

nonC-PA

FBpp0070933

361.6

3218

6.85

FBpp0309979

361.6

3218

6.85

Q70PP2

NP_001284967

AHN59438

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

3218 aa isoforms: nonC-PA, nonC-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of a post-splicing multiprotein NMD complex.

(UniProt, Q70PP2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nonC using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nonC_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.13

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nonC in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nonC

View exonic expression by tissue for Dmel\nonC

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31625/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263968

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052743

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263968

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32743

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 24 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nonC

Transgenic constructs containing regulatory region of nonC

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(1)exe2B

(Metzstein and Krasnow, 2006)

Gene duplicated in

Dp(1;3)ct^J8

(Daborn et al., 2000)

Gene partially disrupted in

Df(1)CRIMIC-CR70130

(Gene Disruption Project members, 2018-)

Df(1)mAChR-C^attP

(Rao and Deng, 2019.10.23)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nonC^GD11349

viable, with Scer\GAL4^Mef2.PR

nonC^GD11349

viable, with Scer\GAL4^pnr-MD237

nonC^GD11349

viable, with Scer\GAL4^tin.CΔ4

nonC^GD11349

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

fertile

nonC^32AP

Other Phenotypes

Allele

abnormal neuroanatomy

abnormal neurophysiology

abnormal neurophysiology | dominant

nonC¹

abnormal neurophysiology | recessive

nonC¹

chemical resistant

nonC^rst2

chemical resistant, with Scer\GAL4^αTub84B.PL

nonC^RNAi.UAS

chemical resistant (with nonC^rst1)

nonC^rst2

chemical resistant (with nonC^rst2)

nonC^rst1

chemical resistant | recessive

Phenotype manifest in

Allele

bouton

neuromuscular junction

synapse

synaptic vesicle

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

Hsap\SMG1

12 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SH3PXD2B

1 of 14

Yes

Hsap\TRRAP

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

Rnor\Mtor

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (15)

Mmus\Smg1

12 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Sh3pxd2b

1 of 14

Yes

Mmus\Trrap

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\smg1

9 of 13

Yes

Xtro\alox12b

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slc25a28

1 of 13

Danio rerio (Zebrafish) (15)

Drer\smg1

11 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\smg-1

9 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (10)

Agam\AgaP_AGAP000368

11 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\TOR

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\TOR1

2 of 13

Yes

Scer\TOR2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\tor1

2 of 12

Yes

Spom\tor2

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:nonC. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

4 of 13

3 of 13

2 of 13

2 of 13

1 of 13

fwd

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SMG1; SMG1 nonsense mediated mRNA decay associated PI3K related kinase

12 of 14

607032

MTOR; mechanistic target of rapamycin kinase

3 of 14

601231

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

nonC - vtd

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Ribeiro et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Component of a post-splicing multiprotein NMD complex.

(UniProt, Q70PP2 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263968

MIST (protein-protein) - An integrated Molecular Interaction Database

31625

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q70PP2

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-18

Cytogenetic map

6D3-6D4

Sequence location

X:6,824,496..6,838,122 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

6D3-6D4

Limits computationally determined from genome sequence between P{EP}C3G^EP1613 and P{EP}EP1388^EP1388&P{EP}EP1573

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Mapped using (unspecified) deficiency and duplication chromosomes.

(Daborn et al., 1998)

6C1-6E2

(Daborn et al., 1998)

Experimentally Determined Recombination Data

Location

1-18

(FlyBase, 2016)

1-19.7

(Comeron et al., 2012)

1-17.5--18.2

(Daborn et al., 2000)

(Daborn et al., 1998)

Left of (cM)

(Daborn et al., 2000)

Right of (cM)

(Daborn et al., 2000)

Notes

1-17.5 map position obtained using Smg1^rst1. 1-18.2 map position obtained using Smg1^rst2.

(Daborn et al., 2000)

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

42246

nonC¹

26614

w^* P{EP}nonC^G1076

31094

y¹ v¹; P{TRiP.JF01559}attP2

41945

y¹ v¹; P{TRiP.HMS02342}attP40

81027

y¹ w^* nonC^32AP P{neoFRT}19A

84521

w^* Df(1)mAChR-C^attP, TI{TI}mAChR-C^attP

97702

y¹ w^* TI{CRIMIC.TG4.0}nonC^{CR02953-TG4.0}

11322

v108450

v41988

w¹¹¹⁸; P{GD11349}v41988

v341448

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00516}attP40/CyO-GFP

v341634

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00726}attP40/CyO-GFP

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD17186

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263968

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Loss of nonC function impairs basal synaptic efficacy and reduces the fidelity of neurotransmission.

(Long et al., 2010)

nonC facilitates gross neuromuscular junction synaptic morphological development, but does not appear to be required for maintenance of pre- and postsynaptic molecular specializations in individual boutons.

(Long et al., 2010)

nonC is involved in regulation of the trafficking underlying synaptic vesicle pools.

(Long et al., 2010)

nonC mutants exhibit impaired presynaptic function at the level of whole animal and single synaptic boutons.

(Long et al., 2010)

Loss of nonC prevents the synaptic vesicle cycle from maintaining the rate required during periods of demand for high-frequency transmission.

(Long et al., 2010)

Two nonsense alleles of Smg1 do not affect nonsense-mediated decay in D.melanogaster.

(Chen et al., 2005)

dsRNA made from templates generated with primers directed against Smg1 that is transfected into S2 treated with Listeria monocytogenes reveals Smg1 to be involved in Listeria monocytogenes entry.

(Cheng et al., 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Mutants show resistance to cyromazine growth regulator.

(Daborn et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Smg1 anon-WO0170980.133

(FlyBase, 1996-)

Source for merge of: Smg1 anon- EST:Liang-1.24

(Ashburner, 2004.6.30)

Source for merge of: Smg1 rst(1a)cyr

(Chen et al., 2005)

Source for merge of: CG4549 CG4555

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Source for merge of: nonC Smg1

(Long et al., 2010)

Additional comments

Annotations CG4549 and CG4555 merged as CG32743 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of Smg1 anon-WO0170980.133 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Source for merge of CG4549 CG4555 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG32743

(Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Chen et al., 2006, Ashburner, 2004.6.30, Song et al., 2004)

CG4549

(Miranda-Saavedra and Barton, 2007, Chen et al., 2006, Rehwinkel et al., 2005, Song et al., 2004, Gatfield et al., 2003, Sekelsky, 2000.6.12, Zhang et al., 2000)

CG4555

(Chen et al., 2006, Song et al., 2004)

SMG1

(Rehwinkel et al., 2005, Rehwinkel et al., 2005, Gatfield et al., 2003)

Smg

(Meister, 2013, Firth and Baker, 2007)

Smg1

(Ri et al., 2019, Nelson et al., 2018, Yasunaga et al., 2014, Frizzell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Mourikis et al., 2010, Firth and Baker, 2007, Junion et al., 2007, Metzstein et al., 2007, Metzstein and Krasnow, 2006)

anon-EST:Liang-1.24

anon-WO0170980.133

clone 1.24

(Liang and Biggin, 1998)

dSmg1

(Chen et al., 2006)

nonC

(Ostalé et al., 2021, Rathore et al., 2020, Wang et al., 2020, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2018-, Lavoy et al., 2018, Brewer-Jensen et al., 2016, Ribeiro et al., 2016, Vedanayagam and Garrigan, 2015, Sopko et al., 2014, Yamamoto et al., 2013-, Kim et al., 2012, Long et al., 2010)

rst(1a)cyr

(Daborn et al., 2000, Daborn et al., 1998)

smg1

(Hudson et al., 2023, Avery et al., 2011, Zhang et al., 2010, Bakal et al., 2008, Cheng et al., 2005)

Name Synonyms

FRAP-related

(Morrison et al., 2000)

Smg1

no on or off transient C

no-on-and-no-off transient C

(Long et al., 2010)

resistance 1a cyromazine

(Daborn et al., 1998)

Secondary FlyBase IDs

FBgn0002959
FBgn0052743
FBgn0024193
FBgn0026002
FBgn0029908
FBgn0029910
FBgn0046599

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31625

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q70PP2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q70PP2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JDZ8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q70PP2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31625/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263968

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263968

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32743

MARRVEL_MODEL - MARRVEL (model organism gene)

31625

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263968

DroID - A comprehensive database of gene and protein interactions.

FBgn0263968

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nonC_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052743

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263968

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32743

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031024

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

31625

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q70PP2

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

2.13

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