FB2024_03 , released April 23, 2024
Gene: Dmel\tefu
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General Information
Symbol
Dmel\tefu
Species
D. melanogaster
Name
telomere fusion
Annotation Symbol
CG6535
Feature Type
protein_coding_gene
FlyBase ID
FBgn0045035
Gene Model Status
Current
Stock Availability
15 publicly available
Enzyme Name (EC)
non-specific serine/threonine protein kinase (2.7.11.1)
Gene Summary
Serine/threonine-protein kinase which recognizes the substrate consensus sequence (UniProt, Q5EAK6)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ATM, dATM, atm/tefu, ataxia telangiectasia mutated

Key Links
Genomic Location
Cytogenetic map
88E3-88E4
Sequence location
Recombination map
3-56
RefSeq locus
NT_033777 REGION:15232212..15242236
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables histone kinase activity
inferred from direct assay
(Hong and Choi, 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000124197
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR038980, InterPro:IPR044107
(InterPro Project Members, 2004-)
Biological Process (16 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in chromosome organization
inferred from mutant phenotype
(Bi et al., 2004, Silva et al., 2004, Song et al., 2004)
involved_in DNA repair
inferred from mutant phenotype
(Ciapponi et al., 2006)
involved_in meiotic DNA double-strand break processing
inferred from direct assay
(Joyce et al., 2011)
involved_in mitotic G2 DNA damage checkpoint signaling
inferred from mutant phenotype
(Bi et al., 2005)
involved_in negative regulation of G1/S transition of mitotic cell cycle
inferred from genetic interaction with FLYBASE:stg; FB:FBgn0003525
(Rimkus et al., 2008)
acts_upstream_of negative regulation of glial cell apoptotic process
inferred from mutant phenotype
(Petersen et al., 2012)
acts_upstream_of negative regulation of innate immune response
inferred from mutant phenotype
(Petersen et al., 2012)
involved_in oocyte karyosome formation
inferred from direct assay
(Joyce et al., 2011)
involved_in photoreceptor cell maintenance
inferred from mutant phenotype
(Rimkus et al., 2008)
involved_in post-translational protein modification
inferred from direct assay
(Hong and Choi, 2013)
involved_in subtelomeric heterochromatin formation
inferred from mutant phenotype
(Oikemus et al., 2004)
involved_in telomere maintenance
inferred from mutant phenotype
(Ciapponi et al., 2006, Bi et al., 2005, Bi et al., 2004)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in DNA damage checkpoint signaling
inferred from biological aspect of ancestor with PANTHER:PTN001673294
(GO Reference Genome Project, 2011-)
involved_in DNA repair
inferred from electronic annotation with InterPro:IPR044107
(InterPro Project Members, 2004-)
involved_in double-strand break repair
inferred from biological aspect of ancestor with PANTHER:PTN001673294
(GO Reference Genome Project, 2011-)
involved_in intrinsic apoptotic signaling pathway in response to DNA damage
inferred from biological aspect of ancestor with PANTHER:PTN001673305
(GO Reference Genome Project, 2011-)
involved_in negative regulation of TORC1 signaling
inferred from biological aspect of ancestor with PANTHER:PTN001673294
(GO Reference Genome Project, 2011-)
involved_in telomere maintenance
inferred from biological aspect of ancestor with PANTHER:PTN001673294
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Hong and Choi, 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001673294
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000124197
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the PI3/PI4-kinase family. ATM subfamily. (Q5EAK6)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine kinase activity
(1) ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] (2.7.11.1)
(2) ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl- [protein] (2.7.11.1)
Summaries
Gene Group (FlyBase)
ATYPICAL PROTEIN KINASES -
Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.
Protein Function (UniProtKB)
Serine/threonine-protein kinase which recognizes the substrate consensus sequence
(UniProt, Q5EAK6)
Summary (Interactive Fly)

Phosphatidylinositol 3- and 4-kinase - serves as Drosophila's ATM (ataxia telangiectasia mutated) - plays a conserved and essential role in the maintenance of normal telomeres and chromosome stability

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\tefu for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q5EAK6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tefu-RB
FBtr0110874
NM_001043247
8416
2767
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
tefu-PB
FBpp0110174
318.0
2767
7.37
Q5EAK6
NP_001036712
ABI31168
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tefu using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.34

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Hong and Choi, 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\tefu in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 24 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tefu
Transgenic constructs containing regulatory region of tefu
Aberrations (Deficiencies and Duplications) ( 10 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | heat sensitive
lethal | heat sensitive (with Df(3R)PG4)
lethal | maternal effect (with tefuatm-6)
lethal | maternal effect (with tefuZIII-5190)
lethal | recessive
lethal | recessive | heat sensitive
lethal - all die before end of P-stage
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage | recessive
lethal - all die during embryonic stage | non-rescuable maternal effect (with tefustg)
lethal - all die during embryonic stage | non-rescuable maternal effect (with tefuZIII-5190)
lethal - all die during embryonic stage | non-rescuable maternal effect | recessive
lethal - all die during pupal stage (with tefuatm-3)
lethal - all die during pupal stage (with tefuatm-6)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable | conditional
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female sterile | recessive
Other Phenotypes
Allele
abnormal cell cycle | larval stage
abnormal DNA repair | adult stage | conditional, with Scer\GAL4NP5130
abnormal DNA repair | larval stage
abnormal DNA repair | third instar larval stage, with Scer\GAL4hh.PU
abnormal locomotor behavior | adult stage
abnormal locomotor behavior | adult stage, with Scer\GAL4elav-C155
abnormal locomotor behavior | adult stage, with Scer\GAL4repo
abnormal locomotor behavior | adult stage | dominant | conditional
abnormal locomotor behavior | female | heat sensitive (with Df(3R)PG4)
abnormal locomotor behavior | male | heat sensitive (with Df(3R)PG4)
abnormal mitotic cell cycle
abnormal mitotic cell cycle (with tefu1)
abnormal mitotic cell cycle (with tefuatm-3)
abnormal mitotic cell cycle (with tefuatm-6)
abnormal mitotic cell cycle (with tefuΔ356)
abnormal mitotic cell cycle | embryonic stage | maternal effect (with tefustg)
abnormal mitotic cell cycle | embryonic stage | maternal effect (with tefuZIII-5190)
abnormal mitotic cell cycle | larval stage
abnormal mitotic cell cycle | third instar larval stage
abnormal neuroanatomy, with Scer\GAL4elav.PU
abnormal neuroanatomy, with Scer\GAL4GMR.PU
abnormal neuroanatomy | adult stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | adult stage, with Scer\GAL4repo
abnormal neuroanatomy | adult stage | progressive
abnormal neuroanatomy | temperature conditional, with Scer\GAL4hs.PB
abnormal size | adult stage
abnormal size | third instar larval stage | heat sensitive
decreased cell death | third instar larval stage, with Scer\GAL4elav.PU
decreased cell number | adult stage | progressive, with Scer\GAL4NP5130
decreased cell number | spermatogenesis, with Scer\GAL4nanos.PU
decreased fecundity | female | recessive
increased cell death
increased cell death | adult stage
increased cell death | adult stage, with Scer\GAL4repo
increased cell death | adult stage | semidominant
increased cell death | heat sensitive
increased cell death | third instar larval stage, with Scer\GAL4elav.PU
increased cell death | third instar larval stage | heat sensitive
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PU
long lived, with Scer\GAL4elav.PLu
majority die during pharate adult stage
melanotic mass phenotype | third instar larval stage
radiation resistant | cell non-autonomous, with Scer\GAL4ptc-559.1
radiation sensitive
radiation sensitive (with Df(3R)PG4)
short lived
short lived, with Scer\GAL4NP5130
short lived, with Scer\GAL4repo
short lived | dominant
some die during pupal stage
some die during pupal stage | recessive
visible | recessive | heat sensitive
visible | somatic clone
Phenotype manifest in
Allele
adult optic lobe, with Scer\GAL4elav-C155
adult thorax & chaeta | conditional ts (with Df(3R)PG4)
anaphase & condensed nuclear chromosome
anaphase & condensed nuclear chromosome (with tefuatm-3)
anaphase & condensed nuclear chromosome (with tefuatm-6)
antenna | P-stage
chaeta | P-stage
chromosome
chromosome, telomeric region
chromosome, telomeric region (with tefuatm-3)
chromosome, telomeric region (with tefuatm-6)
chromosome, telomeric region | embryonic stage | maternal effect (with tefustg)
chromosome, telomeric region | embryonic stage | maternal effect (with tefuZIII-5190)
chromosome & neuroblast | third instar larval stage 2
chromosome | larval stage
chromosome | male | third instar larval stage
cleavage nucleus | germline clone | maternal effect
condensed chromosome
dorsal appendage | germline clone | maternal effect
egg chorion | germline clone | maternal effect
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryo | maternal effect, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
embryonic/larval brain | larval stage
embryonic/larval brain | male | third instar larval stage
embryonic/larval brain | third instar larval stage
enteroblast of posterior adult midgut epithelium | conditional, with Scer\GAL4NP5130
enteroblast of posterior adult midgut epithelium | progressive, with Scer\GAL4NP5130
eye
eye, with Scer\GAL4GMR.PU
eye (with Df(3R)PG4)
eye (with tefu1)
eye (with tefuΔ356)
eye | heat sensitive
eye | heat sensitive (with Df(3R)PG4)
eye | P-stage
eye | somatic clone
eye-antennal disc | heat sensitive
eye disc
eye disc | anterior | heat sensitive
eye disc posterior to the morphogenetic furrow | third instar larval stage, with Scer\GAL4elav.PU
eye disc posterior to the morphogenetic furrow | third instar larval stage, with Scer\GAL4GMR.PU
eye photoreceptor cell | temperature conditional, with Scer\GAL4hs.PB
eye photoreceptor cell | third instar larval stage, with Scer\GAL4elav.PU
eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PU
glial cell, with Scer\GAL4repo
interommatidial bristle
intestinal stem cell of posterior adult midgut epithelium | conditional, with Scer\GAL4NP5130
intestinal stem cell of posterior adult midgut epithelium | progressive, with Scer\GAL4NP5130
karyosome | heat sensitive
lamina, with Scer\GAL4repo
larval neuroblast
larval neuroblast | larval stage
leg | P-stage
macrochaeta
macrochaeta (with Df(3R)PG4)
macrochaeta (with tefu1)
macrochaeta (with tefuΔ356)
male germline stem cell | absent | adult stage, with Scer\GAL4nanos.PU
melanotic mass | third instar larval stage
metaphase & condensed nuclear chromosome (with tefuatm-3)
metaphase & condensed nuclear chromosome (with tefuatm-6)
mitosis & nuclear chromosome
mitosis & nuclear chromosome | maternal effect | germ-line clone
neuron, with Scer\GAL4repo
neuropil
neuropil, with Scer\GAL4repo
nuclear chromosome | third instar larval stage
nucleus | third instar larval stage
ommatidium
rhabdomere of eye photoreceptor cell, with Scer\GAL4elav.PU
rhabdomere of eye photoreceptor cell, with Scer\GAL4GMR.PU
spindle | germline clone | maternal effect
wing
wing (with Df(3R)PG4)
wing (with tefu1)
wing (with tefuΔ356)
wing | heat sensitive
wing | heat sensitive (with Df(3R)PG4)
wing | P-stage
wing disc
wing disc | cell non-autonomous, with Scer\GAL4ptc-559.1
wing disc | larval stage
wing disc | third instar larval stage, with Scer\GAL4hh.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\ATM
10 of 14
Yes
Yes
Hsap\ATR
2 of 14
No
No
2  
Hsap\MTOR
2 of 14
No
No
1  
Hsap\PRKDC
1 of 14
No
No
Hsap\SMG1
1 of 14
No
No
Hsap\TRRAP
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Atm
11 of 14
Yes
Yes
Rnor\Atr
2 of 14
No
No
Rnor\Mtor
2 of 14
No
No
Rnor\Prkdc
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Atm
11 of 14
Yes
Yes
Mmus\Atr
2 of 14
No
No
Mmus\Mtor
1 of 14
No
No
Mmus\Prkdc
1 of 14
No
No
Mmus\Smg1
1 of 14
No
No
Mmus\Trrap
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\atm
9 of 13
Yes
Yes
Xtro\atr
1 of 13
No
No
Xtro\mtor
1 of 13
No
No
Xtro\smg1
1 of 13
No
No
Xtro\trrap
1 of 13
No
No
Xtro\upb1
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\atm
9 of 14
Yes
Yes
Drer\atr
2 of 14
No
No
Drer\mtor
2 of 14
No
No
Drer\prkdc
1 of 14
No
No
Drer\smg1
1 of 14
No
No
Drer\trrap
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\atm-1
8 of 14
Yes
Yes
Cele\atl-1
2 of 14
No
No
Cele\let-363
2 of 14
No
No
Cele\trr-1
2 of 14
No
No
Cele\B0273.115
1 of 14
No
Yes
Cele\smg-1
1 of 14
No
No
Cele\Y48G1BL.7
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP009632
9 of 12
Yes
Yes
Agam\AgaP_AGAP007873
2 of 12
No
No
Agam\AgaP_AGAP010313
2 of 12
No
No
Agam\AgaP_AGAP000368
1 of 12
No
No
Agam\AgaP_AGAP003967
1 of 12
No
No
Agam\AgaP_AGAP005533
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\ATM
9 of 13
Yes
Yes
Atha\AT3G48187
2 of 13
No
Yes
Atha\ATR
2 of 13
No
No
Atha\AT2G17930
1 of 13
No
No
Atha\AT4G36080
1 of 13
No
No
Atha\TOR
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\TEL1
10 of 13
Yes
Yes
Scer\MEC1
1 of 13
No
No
Scer\TOR1
1 of 13
No
No
Scer\TOR2
1 of 13
No
No
Scer\TRA1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\tel1
8 of 12
Yes
Yes
Spom\rad3
1 of 12
No
No
Spom\tor1
1 of 12
No
No
Spom\tor2
1 of 12
No
No
Spom\tra1
1 of 12
No
No
Spom\tra2
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:tefu. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
mei-41
4 of 13
mTor
4 of 13
Nipped-A
3 of 13
nonC
2 of 13
Pi3K68D
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 11 )
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
ATM; ATM serine/threonine kinase
model of  breast cancer
IEA
(FlyBase, 2019-)
model of  ataxia telangiectasia
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 3 )
Allele
Disease
Interaction
References
tefuΔ356
model of  ataxia telangiectasia
is ameliorated by p53R155H.UAS.Ex
(Song et al., 2004)
tefuatm-8
model of  neurodegenerative disease
is ameliorated by RelE20
(Petersen et al., 2013)
is ameliorated by RelE38
(Petersen et al., 2013)
tefuRNAi.UAS
model of  ataxia telangiectasia
is exacerbated by Delta05151
(Rimkus et al., 2008)
is ameliorated by HDAC104556
(Rimkus et al., 2008)
is exacerbated by Mekk1EY02276
(Rimkus et al., 2008)
is ameliorated by rad50EP1
(Rimkus et al., 2008)
is ameliorated by stgEY12388
(Rimkus et al., 2008)
is exacerbated by wrdA131
(Rimkus et al., 2008)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ATM; ATM serine/threonine kinase
10 of 14
607585
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
Show/hide secondary interactors 
(data from AllianceMine provided by esyN)
esyN Network Key:
Suppression
Enhancement
Other Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
tefu
enhanceable
cav
(Oikemus et al., 2006)
tefu
enhanceable
Clbn
(Wang et al., 2013)
tefu
enhanceable
Delta
(Rimkus et al., 2008)
tefu
suppressible
DNAlig4
(Bi et al., 2004)
tefu
suppressible
HDAC1
(Rimkus et al., 2008)
tefu
enhanceable
mei-41
(Park et al., 2015, Ciapponi et al., 2006, Oikemus et al., 2006, Bi et al., 2005)
tefu
suppressible
mei-41
(Joyce et al., 2011)
tefu
suppressible
mei-W68
(Joyce et al., 2011)
tefu
enhanceable
Mekk1
(Rimkus et al., 2008)
tefu
enhanceable
moi
(Komonyi et al., 2009)
tefu
enhanceable
mus304
(Oikemus et al., 2006, Bi et al., 2005)
tefu
enhanceable
nbs
(Ciapponi et al., 2006)
tefu
suppressible
nbs
(Oikemus et al., 2006)
tefu
suppressible
p53
(Oikemus et al., 2004, Song et al., 2004)
tefu
enhanceable
p53
(Wang et al., 2013)
tefu
suppressible
rad50
(Rimkus et al., 2008)
tefu
enhanceable
rad50
(Ciapponi et al., 2006)
tefu
suppressible
Rel
(Petersen et al., 2013)
tefu
suppressible
stg
(Rimkus et al., 2008)
tefu
enhanceable
Tctp
(Hong and Choi, 2013)
tefu
suppressible
Tctp
(Hong and Choi, 2013)
tefu
enhanceable
Top2
(Mengoli et al., 2014)
tefu
enhanceable
wrd
(Rimkus et al., 2008)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
aurA
suppressible
tefu
(Merigliano et al., 2019)
cav
enhanceable
tefu
(Oikemus et al., 2006)
His1
suppressible
tefu
(Bayona-Feliu et al., 2017)
MAGE
enhanceable
tefu
(Li et al., 2013)
mei-41
enhanceable
tefu
(Park et al., 2015, Ciapponi et al., 2006)
moi
enhanceable
tefu
(Komonyi et al., 2009)
mus304
enhanceable
tefu
(Oikemus et al., 2006)
nbs
enhanceable
tefu
(Ciapponi et al., 2006)
nbs
suppressible
tefu
(Oikemus et al., 2006)
pbl
suppressible
tefu
(Gregory et al., 2007)
pbl
enhanceable
tefu
(Gregory et al., 2007)
rad50
enhanceable
tefu
(Ciapponi et al., 2006)
Tctp
enhanceable
tefu
(Hong and Choi, 2013)
Top2
enhanceable
tefu
(Mengoli et al., 2014)
tws
suppressible
tefu
(Merigliano et al., 2017)
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-56
Cytogenetic map
88E3-88E4
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
88E3-88E4
Limits computationally determined from genome sequence between P{EP}CG33967EP666 and P{lacW}Hsc70-4L3929
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
88B5-88C4
(Queiroz-Machado et al., 2001)
Experimentally Determined Recombination Data
Location

3-56

(FlyBase, 2016)

3-55.8

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (15)
Genomic Clones (21)
cDNA Clones (6)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Hong and Choi, 2013, Chiolo et al., 2011)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        tefu is required for double strand break repair in the oocyte.

        (Joyce et al., 2011)

        tefu is not essential for cell cycle arrest at high doses of X-irradiation.

        (Oikemus et al., 2006)

        tefu mutants show a high level of spontaneous telomere fusions in larval neuroblasts.

        (Bi et al., 2004)

        tefu is required for the maintenance of normal telomeres.

        (Bi et al., 2004, Silva et al., 2004, Song et al., 2004)

        tefu mutants show a high level of spontaneous telomere fusions and other chromosome abnormalities in larval neuroblasts.

        (Silva et al., 2004)

        tefu mutants show a high level of spontaneous telomere fusions in larval neuroblasts. Mutants show an increase in spontaneous p53-dependent apoptosis.

        (Song et al., 2004)

        S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on proteolysis of dup and geminin genes.

        (Higa et al., 2003)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        tefu is essential for normal cell proliferation, the gene may have a role in protecting the linear ends of chromosomes.

        (Queiroz-Machado et al., 2001)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: tefu atm

        (Oikemus, 2004.2.25)
        Additional comments

        Source for identity of atm CG6535 was sequence comparison ( date:040205 ).

        (FlyBase, 1996-)
        Nomenclature History
        Source for database identify of

        Source for identity of: tefu atm

        (Oikemus et al., 2004)

        Source for identity of: atm CG6535

        (FlyBase, 1996-)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (17)
        Reported As
        Symbol Synonym
        ATM
        (Nayak and Mishra, 2022, Hounsell and Fan, 2021, Cacchione et al., 2020, Kim et al., 2020, Na et al., 2020, Park et al., 2018, Rimkus and Wassarman, 2018, Amaral et al., 2017, Khan et al., 2017, Derive et al., 2015, Park et al., 2015, Sun and Chen, 2015, Bilak et al., 2014, Mengoli et al., 2014, Li et al., 2013, Petersen et al., 2013, Raffa et al., 2013, Petersen et al., 2012, Kondo and Perrimon, 2011, Lu et al., 2010, Cenci et al., 2008, Mehrotra et al., 2008, Rimkus et al., 2008, Garcia et al., 2007, Gregory et al., 2007, Katzenberger et al., 2006, Cenci et al., 2005, Rehwinkel et al., 2005, Brodsky et al., 2004, Purdy and Su, 2004, Higa et al., 2003, Silva et al., 2003, Morrison et al., 2000, Morrison et al., 2000)
        Atm
        (Lee et al., 2016, Raffa et al., 2011)
        CG6535
        (Çiçek et al., 2016, Christis and Munro, 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Miranda-Saavedra and Barton, 2007, Molnar et al., 2006, Gong et al., 2005, Rehwinkel et al., 2005, Brodsky et al., 2004, Campbell et al., 2004, Song et al., 2004, Laurencon et al., 2003, Bronk et al., 2001, Sekelsky et al., 2000, Zhang et al., 2000)
        Tefu
        (Baonza et al., 2022, Chang et al., 2021, Parra-Peralbo et al., 2021, Amaral et al., 2017, Bayona-Feliu et al., 2017, Caridi et al., 2017, Lu et al., 2014, Raffa et al., 2013, Hochwagen, 2006)
        atm
        (Liu et al., 2022, Flegel et al., 2016, Hong and Choi, 2016, Ida et al., 2013, Joyce et al., 2011, Gao et al., 2010, Komonyi et al., 2009, Morciano et al., 2009, Castellanos et al., 2008, Doheny et al., 2008, Klovstad et al., 2008, Rong, 2008, Rong, 2008, Klattenhoff et al., 2007, Baehrecke, 2006, Cenci et al., 2006, Oikemus et al., 2006, Oikemus et al., 2006, Wells et al., 2006, Bi et al., 2005, Raffa et al., 2005, Bi et al., 2004, Oikemus et al., 2004, Oikemus et al., 2004, Silva et al., 2004)
        atm/tefu
        (Oikemus et al., 2007, Oikemus et al., 2006)
        dATM
        (Porrazzo et al., 2022, Murcia et al., 2019, Bayona-Feliu et al., 2017, Hong and Choi, 2013, Wang et al., 2013, Pedersen et al., 2010, Yamasaki et al., 2007, Song et al., 2004)
        tef
        (Queiroz-Machado et al., 2001)
        tefu
        (Datta and Bangi, 2024, Hersperger et al., 2024, Muita and Baxter, 2023, Nieken et al., 2023, Beaver et al., 2022, Porrazzo et al., 2022, Bilder et al., 2021, Fabian et al., 2021, Lebo et al., 2021, Mesquita et al., 2021, Vicars et al., 2021, Bolus et al., 2020, Gerlach and Herranz, 2020, Khan et al., 2019, Meltzer et al., 2019, Merigliano et al., 2019, Wei et al., 2019, Gene Disruption Project members, 2018-, Morciano et al., 2018, Merigliano et al., 2017, Vazquez-Pianzola et al., 2017, Ma et al., 2016, Cenci et al., 2015, Guan et al., 2015, Hsu et al., 2015, Kavi et al., 2015, Barclay et al., 2014, Mengoli et al., 2014, Sopko et al., 2014, Li et al., 2013, Morciano et al., 2013, Raffa et al., 2013, Wang et al., 2013, Beaucher et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Lee et al., 2012, Joyce et al., 2011, Reis et al., 2011, Singer and Gall, 2011, Pedersen et al., 2010, Anderson et al., 2009, Christensen et al., 2009.2.28, Komonyi et al., 2009, Morciano et al., 2009, Southall and Brand, 2009, Cenci et al., 2008, Christensen et al., 2008.4.15, Frydrychova et al., 2008, Mehrotra et al., 2008, Musarò et al., 2008, Turner et al., 2008, Gregory et al., 2007, Rickmyre et al., 2007, Chen et al., 2006, Ciapponi et al., 2006, Molnar et al., 2006, Oikemus et al., 2006, Bi et al., 2005, Bi et al., 2005, Gong et al., 2005)
        tefu/atm
        (Morciano et al., 2018)
        Name Synonyms
        A-T mutated
        (Petersen et al., 2012)
        Ataxia Telangectasia Mutated
        (Morciano et al., 2018)
        Drosophila ATM
        (Brodsky et al., 2004)
        ataxia telangiectasia mutated
        (Doheny et al., 2008, Baehrecke, 2006)
        ataxia telengiesctasia mutated
        (Castellanos et al., 2008)
        ataxia-telangiectasia mutated
        (Katzenberger et al., 2006)
        telomere fusion
        (Bilak et al., 2014, Raffa et al., 2013, Morciano et al., 2009, Musarò et al., 2008, Pedersen et al., 2008, Rickmyre et al., 2007, Rickmyre et al., 2007, Oikemus et al., 2006, Queiroz-Machado et al., 2001)
        Secondary FlyBase IDs
        • FBgn0038308
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 56 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        References (200)