FB2024_04 , released June 25, 2024
Allele: Dmel\tefuZIII-5190
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General Information
Symbol
Dmel\tefuZIII-5190
Species
D. melanogaster
Name
FlyBase ID
FBal0221021
Feature type
allele
Associated gene
Dmel\tefu
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W356term.

    (Morciano et al., 2013)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:15,240,789..15,240,789 [-]
    Nucleotide change:

    G15240789A

    Amino acid change:

    W357term | tefu-PB

    Reported amino acid change:

    W356term

    Comment:

    TGG to TGA nonsense mutation in Trp codon.

    (Morciano et al., 2013)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        tefuZIII-5190/tefustg adults are recovered at a Mendelian ratio, indicating that the tefuZIII-5190 allele minimally affects viability.

        Homozygous larval neuroblasts show a near background level of telomere fusion.

        tefuZIII-5190/tefuatm-6 females do not produce viable offspring.

        Homozygous and tefuZIII-5190/tefustg females produce a normal amount of eggs. However, none of the embryos hatch, regardless of paternal genotype. The embryos show significant development, indicating that they are fertilised. Mitotic defects are seen in 0-2 hour embryos derived from tefuZIII-5190/tefustg females: chromosome bridges are seen between segregating nuclei, multilobed nuclei are seen and large areas of the surface of the embryo which are free of nuclei are observed. Metaphase chromosomes exhibit end-to-end telomere fusions.

        (Morciano et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        tefuZIII-5190/tefuatm-6 is rescued by tefu+t14.5

        (Morciano et al., 2013)
        Comments

        tefu+t14.5 rescues the inability of tefuZIII-5190/tefuatm-6 females to produce viable offspring.

        (Morciano et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        ZIII-5190
        (Rickmyre et al., 2007)
        atm5190
        (Beaucher et al., 2012)
        tefu5190
        (Beaucher et al., 2012)
        tefuZIII-5190
        (Morciano et al., 2013, Beaucher et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)