FlyBase Allele Report: Dmel\tefu[unspecified]

General Information

Symbol

Dmel\tefu^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0158583

Feature type

allele

Associated gene

Dmel\tefu

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of ataxia telangiectasia

CEA

(Oikemus et al., 2004)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | third instar larval stage

(Bi et al., 2005)

abnormal size | adult stage

(Song et al., 2004)

lethal - all die before end of pupal stage

(Bi et al., 2005)

some die during pupal stage

(Bi et al., 2005)

Phenotype Manifest In

anaphase & condensed nuclear chromosome

(Oikemus et al., 2004)

chromosome & neuroblast | third instar larval stage 2

(Bi et al., 2005)

eye

(Song et al., 2004)

interommatidial bristle

(Song et al., 2004)

ommatidium

(Song et al., 2004)

wing disc | larval stage

(Song et al., 2004)

Detailed Description

Statement

Reference

Third instar larval neuroblasts of tefu^unspecified mutants have an average of 3 fused chromosome ends per cell.

(Bi et al., 2005)

Anaphase bridges are sometimes seen in mutant imaginal discs.

(Oikemus et al., 2004)

Escaper adult homozygotes have eyes that are smaller than normal, have a rough phenotype and are missing some bristles. Mutant wing discs contain significantly more mitotic cells 25 minutes after irradiation compared to control wild-type discs. At later time points following irradiation, G2 arrest occurs normally in mutant wing discs.

(Song et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tefu^unspecified has abnormal mitotic cell cycle | third instar larval stage phenotype, enhanceable by mei-41^RT1

(Bi et al., 2005)

tefu^unspecified has abnormal mitotic cell cycle | third instar larval stage phenotype, enhanceable by mei-41^29D

(Bi et al., 2005)

tefu^unspecified has abnormal mitotic cell cycle | third instar larval stage phenotype, enhanceable by mus304^D3/mus304^D3

(Bi et al., 2005)

tefu^unspecified has abnormal mitotic cell cycle | third instar larval stage phenotype, enhanceable by mus304^D3/mus304^D1

(Bi et al., 2005)

Other

Statement

Reference

mei-41^29D, tefu^unspecified has decreased occurrence of cell division | third instar larval stage phenotype

(Bi et al., 2005)

mei-41^RT1, tefu^unspecified has lethal | wandering third instar larval stage phenotype

(Bi et al., 2005)

mei-41^RT1, tefu^unspecified has abnormal developmental rate | wandering third instar larval stage phenotype

(Bi et al., 2005)

mei-41^RT1, tefu^unspecified has decreased occurrence of cell division | third instar larval stage phenotype

(Bi et al., 2005)

mei-41^29D, tefu^unspecified has lethal | wandering third instar larval stage phenotype

(Bi et al., 2005)

mei-41^29D, tefu^unspecified has abnormal developmental rate | wandering third instar larval stage phenotype

(Bi et al., 2005)

mei-41^unspecified, tefu^unspecified has melanotic mass phenotype phenotype

(Song et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, enhanceable by mei-41^RT1

(Bi et al., 2005)

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, enhanceable by mei-41^29D

(Bi et al., 2005)

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, enhanceable by mei-41^D9

(Bi et al., 2005)

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, enhanceable by mus304^D3/mus304^D3

(Bi et al., 2005)

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, enhanceable by mus304^D3/mus304^D1

(Bi et al., 2005)

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, enhanceable by mus304^D1/mus304^D1

(Bi et al., 2005)

NOT Enhanced by

Statement

Reference

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, non-enhanceable by grp⁰⁶⁰³⁴

(Bi et al., 2005)

tefu^unspecified has chromosome & neuroblast | third instar larval stage 2 phenotype, non-enhanceable by lok^p6

(Bi et al., 2005)

Other

Statement

Reference

mei-41^unspecified, tefu^unspecified has melanotic mass phenotype

(Song et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The chromosome fusion phenotype seen in third instar larval neuroblasts of tefu^unspecified mutants is enhanced from an average of approximately 3 fusions per nucleus to an average of approximately 5 per nucleus by mei-41^D9. mei-41^29D and mei-41^RT1 are stronger enhancers of this phenotype (7 fusions per nucleus), with the latter also causing polyploidy in 19% of cases. In these polyploid nuclei, most chromosome ends are fused. This phenotype is also weakly enhanced by mus304^D3/mus304^D3 and more strongly enhanced by mus304^D1/mus304^D3 (5.35 fusions on average) and mus304^D1/mus304^D1 (7.12 fusions per nucleus and 20% of these nuclei are polyploid).

tefu^unspecified; mei-41^RT1 and tefu^unspecified; mei-41^29D double mutants develop more slowly than wild-type animals and arrest as third instar larvae for several days before death. There are fewer mitotic cells in the proliferating tissues of these double mutants.

(Bi et al., 2005)

mei-41^unspecified tefu^unspecified double mutant third instar larvae usually have melanotic tumours.

(Song et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

tefu^unspecified is rescued by Scer\GAL4^unspecified/tefu^UAS.cOa

(Oikemus et al., 2004)

tefu^unspecified is rescued by tefu^+t14.5

(Silva et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

atm^-

(Oikemus et al., 2004)

tefu^unspecified

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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