FlyBase Allele Report: Dmel\mei-41[29D]

General Information

Symbol

Dmel\mei-41^29D

Species

D. melanogaster

Name

FlyBase ID

FBal0104998

Feature type

allele

Associated gene

Dmel\mei-41

Associated Insertion(s)

Carried in Construct

Also Known As

mei41^29D

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Laurencon et al., 2003)

Progenitor genotype

mei-41^RT1

(Laurencon et al., 2003)

Cytology

Description

Imprecise excision of the P-element, resulting in a deletion of 975bp of mei-41 coding sequence. In addition, the excision is accompanied by the insertion of an extra A, resulting in a frameshift in the remaining coding sequence.

(Laurencon et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Bloom syndrome

modeled by Blm^D2, Blm^N1

(Lafave et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon | larval stage | conditional

(Li et al., 2021)

chromosome | larval stage

(Benna et al., 2010)

chromosome | male | third instar larval stage

(Mengoli et al., 2014)

chromosome | third instar larval stage

(Merigliano et al., 2019)

embryonic/larval brain | male | third instar larval stage

(Mengoli et al., 2014)

embryonic/larval brain | third instar larval stage

(Merigliano et al., 2019, Merigliano et al., 2017)

eye disc | conditional

(Jaklevic and Su, 2004)

eye disc morphogenetic furrow | conditional

(Jaklevic and Su, 2004)

larval multidendritic class III neuron | conditional

(Li et al., 2021)

larval multidendritic class I neuron | conditional

(Li et al., 2021)

metaphase & condensed nuclear chromosome | conditional qualifier

(Jaklevic and Su, 2004)

neuroblast | third instar larval stage

(Merigliano et al., 2019)

nuclear chromosome | third instar larval stage

(Merigliano et al., 2017)

wing disc

(LaRocque et al., 2007)

Detailed Description

Statement

Reference

Unlike controls, mei-41^29D mutants show increased class III and class I da neuron axonal regeneration after injury. Larvae with injured class III da neuron T1/T2 bundles show faster recovery of gentle touch response than controls.

(Li et al., 2021)

mei-41^29D third instar larval brain neuroblasts show a small increase in the frequency of chromosomal aberrations, as compared to controls.

(Merigliano et al., 2019)

After 5 Gy X-ray treatment mei-41^29D third instar larval brains exhibit an increase in the frequency of nuclei with γ-H2Av foci (indicative of double strand breaks) similar to controls.

After 10 Gy X-ray treatment, mei-41^29D third instar larval brains fail to exhibit variations in the mitosis index over time compared to controls.

Under normal conditions mei-41^29D third instar larval brains exhibit increased frequency of cells with chromosome aberrations but without telomeric fusions compared to controls.

(Merigliano et al., 2017)

The brains of mei-41^29D/Y mutant third instar larvae (treated with colchicine and hypotonic solution) show a significant increase in the frequency of chromosomal aberrations compared to wild-type.

(Mengoli et al., 2014)

Chromosome breakage is significantly increased compared to wild-type in larval brains under hydroxyurea (HU)-induced deoxyribonucleotide triphosphate (dNTP) pool depletion in homozygous mei-41^29D mutants.

(Benna et al., 2010)

grp^fs1 has no effect on the apoptotic response seen in eye discs containing dicentric chromosomes (generated using Scer\FLP1^hs.PP-induced recombination in chromosomes containing inverted Scer\FRT sites). This effect is seen at 12-14 hours after heat shock of DcYy⁺.

(Titen and Golic, 2008)

Hemizygous males are defective in repair of double strand breaks (DSBs) induced by P-element excision; survival to adulthood of mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is drastically reduced (wild-type males and mei-41^29D males that do not contain the insertion of P{hsw^a} show no lethality). Analysis of the female progeny of surviving males indicates that when DSB repair does occur in the mei-41^29D males, the frequency of repair events that are derived from completed SDSA (synthesis-dependent strand annealing) is reduced (20%) compared to wild-type males (46%).

The mitotic checkpoint normally induced by 4000rad of irradiation is not detectable in mei-41^29D mutants.

(LaRocque et al., 2007)

The average number of apoptotic cells per larval wing disc is increased fourfold in mei-41^29D/Y flies compared to wild type.

mei-41^29D/Y flies show an increase in loss of heterozygosity compared to wild type.

(LaRocque et al., 2007)

Mutant larvae show hypersensitivity to camptothecin, hydroxyurea and nitrogen mustard (showing reduced survival to adulthood when fed one of these compounds).

(Trowbridge et al., 2007)

mei-41^29D mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 32^oC or 38^oC.

(Wei and Rong, 2007)

Mutants of mei-41^29D exhibit exacerbate p53-independent cell death. For example, 1,000 R of radiation, a dose that in wild-type produces little p53-independent cell death, produces robust Acridine Orange staining in mei-41^29D mutants in which the p53-pathway is disrupted.

(Wichmann et al., 2006)

When mutant larvae are exposed to 2000R of X-rays they form pupae but loss than 1% eclose (in wild-type larvae pupate and enclose into healthy viable adult flies). Mutants exposed also delay pupariation. Those exposed to 4000R form pupae but none eclose (wild-type animals eclose into flies that are mostly unable to move). Mutants exhibit a robust cell death response to irradiation. Mutants discs degenerate after irradiation. Mutants are unable to sustain organised cell proliferation after irradiation; although mitotic cells are present, mitotic waves are no longer discernable at 24 hours after irradiation. Furthermore, mutant discs appear smaller at longer times (18-24hr) after irradiation. This appears to be due to a reduction in cell number as cell size remains similar. The reduced size of mutant discs is accompanied by the disappearance of the morphogenetic furrow in the eye disc and tissue folds in the antennae disc. In metaphase chromosomes from larval neuroblasts broken chromosomes are seen in approximately 46% of metaphase cells 3hr after irradiation (compared to about 6% in wild-type).

(Jaklevic and Su, 2004)

Heterozygotes are sensitive to methyl methanesulfonate compared to wild-type animals. Homozygous females are semi-sterile; 97.3% of embryos fail to hatch at 25^o and 92% fail to hatch at 20^o). Homozygous females show meiotic defects such as reduction of recombination and increased chromosome loss and nondisjunction compared to wild type (X chromosome loss is 10%, compared to a control value of less than 1%). Homozygous larvae are unable to block mitosis after irradiation; the number of mitotic cells in mutant eye discs is only slightly reduced after irradiation (156 +/- 10 mitotic cells before irradiation, 127 +/- 21.3 mitotic cells after irradiation), in contrast to wild-type eye discs, where the number of mitotic cells is decreased more than 10-fold after irradiation. Wild-type embryos show an increase in the ratio of metaphase to (anaphase+telophase) 40 minutes after irradiation, compared to unirradiated controls. This increase is partially diminished in homozygous embryos derived from heterozygous females.

(Laurencon et al., 2003)

Homozygous mei-41^29D flies have wild-type eyes.

(Brodsky et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mei-41^29D has abnormal neuroanatomy | larval stage | conditional phenotype, suppressible by Scer\GAL4^19-12/twe^HMS00642

(Li et al., 2021)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has visible phenotype, suppressible by p53^5A-1-4/p53^5A-1-4

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has increased cell death phenotype, suppressible by p53^5A-1-4/p53^5A-1-4

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has visible phenotype, suppressible by CycB[+]/CycB²

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has visible phenotype, suppressible by CycA^C8LR1/CycA[+]

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has increased cell death phenotype, suppressible by CycA^C8LR1/CycA[+]

(LaRocque et al., 2007)

NOT suppressed by

Statement

Reference

mei-41^29D has abnormal neuroanatomy | larval stage | conditional phenotype, non-suppressible by Scer\GAL4^19-12/Mmus\Piezo1^TriM.UAS

(Li et al., 2021)

mei-41^29D has abnormal neuroanatomy | larval stage | conditional phenotype, non-suppressible by Scer\GAL4^19-12/Nos^UAS.cLa

(Li et al., 2021)

Enhancer of

Statement

Reference

mei-41^29D is an enhancer of abnormal cell death | conditional phenotype of lok^p6

(Titen and Golic, 2008)

mei-41^29D is an enhancer of abnormal mitotic cell cycle | third instar larval stage phenotype of tefu^unspecified

(Bi et al., 2005)

NOT Suppressor of

Statement

Reference

mei-41^29D is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of Top2^suo3/Df(2L)Exel9043

(Mengoli et al., 2014)

Other

Statement

Reference

Df(2L)Nos^Δ15/+, mei-41^29D has abnormal neuroanatomy | larval stage | conditional phenotype

(Li et al., 2021)

mei-41^29D, tws⁴³⁰ has lethal - all die before end of larval stage phenotype

(Merigliano et al., 2017)

DNApol-α180[+]/PolA1^Q1132ter, mei-41^29D has visible phenotype

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has visible phenotype

(LaRocque et al., 2007)

PolA1^Q1322ter/DNApol-α180[+], mei-41^29D has visible phenotype

(LaRocque et al., 2007)

mei-41^29D, tefu^unspecified has lethal | wandering third instar larval stage phenotype

(Bi et al., 2005)

mei-41^29D, tefu^unspecified has abnormal developmental rate | wandering third instar larval stage phenotype

(Bi et al., 2005)

mei-41^29D, tefu^unspecified has decreased occurrence of cell division | third instar larval stage phenotype

(Bi et al., 2005)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has visible | recessive phenotype

(Brodsky et al., 2000)

PolA1^Emus304, mei-41^29D has visible phenotype

(Brodsky et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

mei-41^29D has embryonic/larval brain | third instar larval stage phenotype, enhanceable by aurA⁹⁴⁹/aurA⁹⁴⁹

(Merigliano et al., 2019)

mei-41^29D has neuroblast | third instar larval stage phenotype, enhanceable by aurA⁹⁴⁹/aurA⁹⁴⁹

(Merigliano et al., 2019)

mei-41^29D has FlyBase_internalproperty type:chromosome:chromosome | third instar larval stage phenotype, enhanceable by aurA⁹⁴⁹/aurA⁹⁴⁹

(Merigliano et al., 2019)

mei-41^29D has nuclear chromosome | third instar larval stage phenotype, enhanceable by tws⁴³⁰/tws⁴³⁰

(Merigliano et al., 2017)

mei-41^29D has embryonic/larval brain | third instar larval stage phenotype, enhanceable by tws⁴³⁰/tws⁴³⁰

(Merigliano et al., 2017)

mei-41^29D has chromosome | third instar larval stage | male phenotype, enhanceable by Top2^suo1/Top2^suo3

(Mengoli et al., 2014)

mei-41^29D has embryonic/larval brain | third instar larval stage | male phenotype, enhanceable by Top2^suo1/Top2^suo3

(Mengoli et al., 2014)

mei-41^29D has chromosome, telomeric region phenotype, enhanceable by tefu^atm-6

(Ciapponi et al., 2006)

mei-41^29D has chromosome, telomeric region phenotype, enhanceable by nbs¹

(Ciapponi et al., 2006)

mei-41^29D has condensed chromosome phenotype, enhanceable by nbs¹

(Ciapponi et al., 2006)

mei-41^29D has chromosome, telomeric region phenotype, enhanceable by rad50^Δ5.1

(Ciapponi et al., 2006)

mei-41^29D has condensed chromosome phenotype, enhanceable by rad50^Δ5.1

(Ciapponi et al., 2006)

Suppressed by

Statement

Reference

mei-41^29D has axon | larval stage | conditional phenotype, suppressible by Scer\GAL4^19-12/twe^HMS00642

(Li et al., 2021)

mei-41^29D has larval multidendritic class III neuron phenotype, suppressible by Scer\GAL4^19-12/twe^HMS00642

(Li et al., 2021)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has eye phenotype, suppressible by p53^5A-1-4/p53^5A-1-4

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has eye phenotype, suppressible by CycB[+]/CycB²

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has eye phenotype, suppressible by CycA^C8LR1/CycA[+]

(LaRocque et al., 2007)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has wing disc phenotype, suppressible by CycA^C8LR1/CycA[+]

(LaRocque et al., 2007)

NOT suppressed by

Statement

Reference

mei-41^29D has larval multidendritic class III neuron | conditional phenotype, non-suppressible by Scer\GAL4^19-12/Nos^UAS.cLa

(Li et al., 2021)

mei-41^29D has axon | larval stage | conditional phenotype, non-suppressible by Scer\GAL4^19-12/Mmus\Piezo1^TriM.UAS

(Li et al., 2021)

mei-41^29D has larval multidendritic class III neuron | conditional phenotype, non-suppressible by Scer\GAL4^19-12/Mmus\Piezo1^TriM.UAS

(Li et al., 2021)

mei-41^29D has axon | larval stage | conditional phenotype, non-suppressible by Scer\GAL4^19-12/Nos^UAS.cLa

(Li et al., 2021)

Enhancer of

Statement

Reference

mei-41^29D/mei-41^29D is an enhancer of embryonic/larval brain | third instar larval stage phenotype of aurA⁹⁴⁹

(Merigliano et al., 2019)

mei-41^29D/mei-41^29D is an enhancer of neuroblast | third instar larval stage phenotype of aurA⁹⁴⁹

(Merigliano et al., 2019)

mei-41^29D/mei-41^29D is an enhancer of FlyBase_internalproperty type:chromosome:chromosome | third instar larval stage phenotype of aurA⁹⁴⁹

(Merigliano et al., 2019)

mei-41^29D is an enhancer of chromosome | third instar larval stage | male phenotype of Top2^suo1/Top2^suo3

(Mengoli et al., 2014)

mei-41^29D is an enhancer of FlyBase_internalproperty type:chromosome:chromosome | larval stage phenotype of timeout^c06976

(Benna et al., 2010)

mei-41^29D is an enhancer of eye disc | conditional phenotype of lok^p6

(Titen and Golic, 2008)

mei-41^29D is an enhancer of wing disc | conditional phenotype of lok^p6

(Titen and Golic, 2008)

mei-41^29D is an enhancer of chromosome, telomeric region phenotype of nbs¹

(Ciapponi et al., 2006)

mei-41^29D is an enhancer of condensed chromosome phenotype of nbs¹

(Ciapponi et al., 2006)

mei-41^29D is an enhancer of chromosome, telomeric region phenotype of rad50^Δ5.1

(Ciapponi et al., 2006)

mei-41^29D is an enhancer of condensed chromosome phenotype of rad50^Δ5.1

(Ciapponi et al., 2006)

mei-41^29D is an enhancer of chromosome, telomeric region phenotype of tefu^atm-6

(Ciapponi et al., 2006)

mei-41^29D is an enhancer of chromosome & neuroblast | third instar larval stage 2 phenotype of tefu^unspecified

(Bi et al., 2005)

mei-41^29D is an enhancer of chromosome & neuroblast | third instar larval stage 2 phenotype of nbs¹

(Bi et al., 2005)

NOT Enhancer of

Statement

Reference

mei-41^29D is a non-enhancer of nuclear chromosome | third instar larval stage phenotype of tws⁴³⁰

(Merigliano et al., 2017)

mei-41^29D is a non-enhancer of embryonic/larval brain | third instar larval stage phenotype of tws⁴³⁰

(Merigliano et al., 2017)

NOT Suppressor of

Statement

Reference

mei-41^29D is a non-suppressor of nuclear chromosome | third instar larval stage phenotype of tws⁴³⁰

(Merigliano et al., 2017)

mei-41^29D is a non-suppressor of embryonic/larval brain | third instar larval stage phenotype of tws⁴³⁰

(Merigliano et al., 2017)

mei-41^29D is a non-suppressor of embryonic/larval brain | third instar larval stage phenotype of Top2^suo3/Df(2L)Exel9043

(Mengoli et al., 2014)

mei-41^29D is a non-suppressor of karyosome phenotype of Brca2^KO/Brca2^56E

(Klovstad et al., 2008)

mei-41^29D is a non-suppressor of dorsal appendage phenotype of Brca2^KO/Brca2^56E

(Klovstad et al., 2008)

mei-41[+]/mei-41^29D is a non-suppressor of nurse cell phenotype of mio²

(Iida and Lilly, 2004)

mei-41^29D/mei-41^29D is a non-suppressor of nurse cell phenotype of mio²

(Iida and Lilly, 2004)

mei-41[+]/mei-41^29D is a non-suppressor of oocyte phenotype of mio²

(Iida and Lilly, 2004)

mei-41^29D/mei-41^29D is a non-suppressor of oocyte phenotype of mio²

(Iida and Lilly, 2004)

Other

Statement

Reference

Df(2L)Nos^Δ15/+, mei-41^29D has axon | larval stage | conditional phenotype

(Li et al., 2021)

Df(2L)Nos^Δ15/+, mei-41^29D has larval multidendritic class III neuron | conditional phenotype

(Li et al., 2021)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has eye phenotype

(LaRocque et al., 2007, Brodsky et al., 2000)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has ommatidium phenotype

(LaRocque et al., 2007, Brodsky et al., 2000)

DNApol-α180[+]/PolA1^Q1132ter, mei-41^29D has eye phenotype

(LaRocque et al., 2007)

PolA1^Q1322ter/DNApol-α180[+], mei-41^29D has eye phenotype

(LaRocque et al., 2007)

PolA1^Emus304, mei-41^29D has macrochaeta phenotype

(Brodsky et al., 2000)

PolA1^Emus304, mei-41^29D has eye phenotype

(Brodsky et al., 2000)

PolA1^Emus304, mei-41^29D has ommatidium phenotype

(Brodsky et al., 2000)

E(mus304)[+]/PolA1^Emus304, mei-41^29D has macrochaeta phenotype

(Brodsky et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Unlike controls, mei-41^29D, Df(2L)Nos^Δ15 double heterozygotes show increased class III and class I da neuron axonal regeneration after injury.

(Li et al., 2021)

The increased frequency of chromosomal aberrations in third instar larval brain cells characteristic for Top2^suo3/Top2^suo1 and mei-41^29D/Y single mutant males is enhanced further in mei-41^29D/Y;Top2^suo3/Top2^suo1 double mutants.

The low mitotic index observed in Top2^suo3/Df(2L)Exel9043 third instar larval brains cannot be rescued by combination with either mei-41^29D or tefu^atm-3/tefu^atm-3.

(Mengoli et al., 2014)

Larval brains from mei-41^29D; timeout^c06976 double mutants show a dramatic increase in the frequency of aberrant metaphases with respect to either single mutant. The prevalent defect of in mei-41^29D; timeout^c06976 mutant brains consists of metaphases with extensive chromosome fragmentation, a phenotype rarely observed in either mei-41^29D or timeout^c06976 single mutants.

(Benna et al., 2010)

sea^unspecified mei-41^29D double mutants show a 2.5 fold increase in the mitotic index of larval brain neuroblasts compared to sea^unspecified single mutants.

(Morciano et al., 2009)

The addition of mei-41^29D results in little or no suppression of the eggshell patterning and karyosome formation defects of Brca2^KO/Brca2^56E females.

(Klovstad et al., 2008)

mei-41^29D abolishes the residual apoptotic response seen in the eye discs of lok^p6 mutants containing dicentric chromosomes (generated using Scer\FLP1^hs.PP-induced recombination in chromosomes containing inverted Scer\FRT sites). This effect is seen at 12-14 hours after heat shock, using either the DcYy⁺ or the P{inv.FRT}Dc3-FrTr1D chromosome. Wing disc apoptosis is suppressed in mei-41^29D lok^p6 double mutants 12-14 hours after heat shock of DcYy⁺ or P{inv.FRT}Dc3-FrTr1D. At 24 hours after heat shock wing disc apoptosis is suppressed in double mutant cells containing Y chromosome dicentrics, but apoptosis is still seen when dicentric chromosomes are generated on chromosome three. 25% of lok^p6 mei-41^29D double mutant larval neuroblast cells have normal karyotypes 48 hours after dicentric chromosomes production (generated using Scer\FLP1^hs.PP-induced recombination in P{inv.FRT}Dc3-FrTr1D, which contains inverted Scer\FRT sites), whereas 44% appear normal in the dicentric controls. Phenotypes observed in cells with abnormal karyotypes include the presence of multiple acentric chromatids, chromosome fusions and tetraploidy.

(Titen and Golic, 2008)

The lethality seen in mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is completely suppressed by spn-A³/spn-A^093A.

The lethality seen in mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is partly suppressed by CycA^C8LR1/+ or CycB²/+.

The lethality seen in mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is completely suppressed if the female parent carries CycA^C8LR1 and if the male progeny carries both CycA^C8LR1 and CycB².

(LaRocque et al., 2007)

mei-41^29D mutants that are also heterozygous for one of DNApol-α180^Q1132ter or DNApol-α180^Q1322ter have a rough eye phenotype.

mei-41^29D mutants that are also heterozygous for DNApol-α180^Emus304 have a rough eye phenotype that includes fused ommatidia and tissue loss.

Heterozygosity for DNApol-α180^Emus304 further increases the average number of apoptotic cells per larval wing disc is increased fourfold in mei-41^29D/Y flies.

p53^5A-1-4/p53^5A-1-4 completely suppresses the rough eye phenotype of DNApol-α180^Emus304/+ ; mei-41^29D/Y flies. The increased level of apoptosis seen in DNApol-α180^Emus304/+ ; mei-41^29D/Y wing discs is restored by p53^5A-1-4/p53^5A-1-4 to the level seen in mei-41^29D/Y single mutants.

Heterozygosity for DNApol-α180^Emus304 further increases the increase in loss of heterozygosity seen in mei-41^29D/Y flies. There is a significant increase in the frequency of mitotic crossovers in the e to st region of the third chromosome in the double mutants.

The rough eye phenotype seen in mei-41^29D ; DNApol-α180^Emus304/+ adults is partially rescued by CycB²/+ and completely rescued by CycA^C8LR1/+. The increased apoptosis seen in the wing discs of mei-41^29D ; DNApol-α180^Emus304/+ mutants is rescued by CycA^C8LR1/+ to levels indistinguishable from those of mei-41^29D single mutants or mei-41^29D ; CycA^C8LR1/+ mutants.

(LaRocque et al., 2007)

The frequency of total telomeric associations and the frequency of chromosome breaks seen in metaphases of mei-41^29D nbs¹ larval brains is significantly increased compared that seen in each single mutant.

The frequency of total telomeric associations and the frequency of chromosome breaks seen in metaphases of mei-41^29D rad50^Δ5.1 larval brains is significantly increased compared that seen in each single mutant.

The frequency of total telomeric associations seen in metaphases of mei-41^29D tefu^atm-6 larval brains is significantly increased compared that seen in each single mutant.

(Ciapponi et al., 2006)

lok^p6; mei-41^29D mutants develop normally and males are fertile.

The chromosome fusion phenotype seen in third instar larval neuroblasts of tefu^unspecified mutants is enhanced from an average of approximately 3 fusions per nucleus to an average of 7 fusions per nucleus. 19% of the resulting nuclei are also polyploid. tefu^unspecified; mei-41^29D double mutants develop more slowly than wild-type animals and arrest as third instar larvae for several days before death. There are fewer mitotic cells in the proliferating tissues of these double mutants.

The presence of mei-41^29D leads to a synergistic increase in the rate of telomere fusion in the neuroblasts of nbs¹ mutant third instar larvae.

(Bi et al., 2005)

Transformation of oocytes to nurse cells in mio² homozygous females not suppressed by mei-41^29D/+ or mei-41^29D/mei-41^29D.

(Iida and Lilly, 2004)

If homozygous mei-41^29D flies are also heterozygous for E(mus304)¹ they have rough eyes and missing bristles.

(Brodsky et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

29D

(Laurencon et al., 2003)

mei41^29D

(Porrazzo et al., 2022, Li et al., 2021, Klovstad et al., 2008, Ciapponi et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (28)

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