FB2024_04 , released June 25, 2024
Allele: Dmel\tefuatm-5
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General Information
Symbol
Dmel\tefuatm-5
Species
D. melanogaster
Name
FlyBase ID
FBal0175413
Feature type
allele
Associated gene
Dmel\tefu
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Silva et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,233,286..15,233,286 [-]
Nucleotide change:

G15233286A

Amino acid change:

M2495I | tefu-PB

Reported amino acid change:

M2157I

Comment:

One of two nucleotide changes in mutant. Probably not primarily responsible for the phenotype. The difference between the annotated and the reported site of the amino acid change is due to the authors description of a 2429 residue protein, compared to the currently annotated 2767 residue polypeptide. Position of mutation on reference sequence inferred by FlyBase curator.

(Pedersen et al., 2010)
point_mutation
3R:15,235,234..15,235,234 [-]
Nucleotide change:

G15235234A

Comment:

Nucleotide change: GT changed to AT in the splice donor, leading to retention of intron 21. Translation continues past the peptide sequence SLQQAEDFCQ into the retained intron, adding the novel MMVSWEFCDVLF sequence before reaching a premature stop codon. One of two nucleotide changes observed in mutant. The difference between the annotated and the reported site of the amino acid change is due to the authors description of a 2429 residue protein, compared to the currently annotated 2767 residue polypeptide. Position of mutation on reference sequence inferred by FlyBase curator.

(Pedersen et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous pupae have variable morphological defects affecting the antennae, eyes, bristles, wings and legs.

      (Silva et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      atm5
      (Silva et al., 2004)
      tefuatm-5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)