FlyBase Allele Report: Dmel\mei-41[KK101792]

General Information

Symbol

Dmel\mei-41^KK101792

Species

D. melanogaster

Name

FlyBase ID

FBal0231482

Feature type

allele

Associated gene

Dmel\mei-41

Associated Insertion(s)

Carried in Construct

P{KK101792}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101792}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101792

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with BacA\p35^UAS.cHa

(Dekanty et al., 2015)

model of ataxia telangiectasia

CEA with tefu^GD11950

(Park et al., 2015)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | adult stage, with Scer\GAL4^NP5130

(Park et al., 2015)

abnormal DNA repair | adult stage | conditional, with Scer\GAL4^NP5130

(Park et al., 2015)

abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4^19-12

(Li et al., 2021)

decreased cell number | adult stage, with Scer\GAL4^NP5130

(Park et al., 2015)

decreased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Park et al., 2015)

short lived, with Scer\GAL4^NP5130

(Park et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Unlike controls, individuals expressing mei-41^KK101792 under the control of Scer\GAL4^19-12 show increased class III da neuron axonal regeneration after injury.

(Li et al., 2021)

The adulthood-only expression of mei-41^KK101792 under the control of Scer\GAL4^esg-NP5130 (in combination with Gal80[ts], for the temporal control of expression) leads to a severe decrease in life-span, leads to a significant decrease in cell density in the adult midgut, leads to larger and rounder adult midgut progenitor cells (esg-positive intestinal stem cells and enteroblasts), and leads to the adult intestinal stem cells showing significant decreases in relative cell number and in the frequency of DNA replication, as compared to controls. Upon γ-radiation, the adult midgut progenitor cells show an increase in DNA damage, assessed by pS/TQ and γH2AvD immunofluorescence, as compared to irradiated controls.

(Park et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^NP5130, mei-41^KK101792 has abnormal DNA repair | adult stage | conditional phenotype, enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

NOT Enhanced by

Statement

Reference

Scer\GAL4^NP5130, mei-41^KK101792 has abnormal cell shape | adult stage phenotype, non-enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Scer\GAL4^NP5130, mei-41^KK101792 has decreased cell number | adult stage phenotype, non-enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Scer\GAL4^NP5130, mei-41^KK101792 has short lived phenotype, non-enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Scer\GAL4^NP5130, mei-41^KK101792 has decreased occurrence of cell division | adult stage phenotype, non-enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Enhancer of

Statement

Reference

mei-41^KK101792, Scer\GAL4^en.PU is an enhancer of hyperplasia | larval stage | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

mei-41^KK101792/Scer\GAL4^NP5130 is an enhancer of decreased cell number | adult stage | progressive phenotype of Scer\GAL4^NP5130, tefu^GD11950

(Park et al., 2015)

Suppressor of

Statement

Reference

mei-41^KK101792, Scer\GAL4^nub.PU is a suppressor | partially of visible | adult stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

mei-41^KK101792, Scer\GAL4^nub.PU is a suppressor | partially of abnormal size | adult stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

mei-41^KK101792, Scer\GAL4^nub.PU is a suppressor of increased cell death | third instar larval stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^NP5130, mei-41^KK101792 has intestinal stem cell of posterior adult midgut epithelium | conditional phenotype, enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Scer\GAL4^NP5130, mei-41^KK101792 has enteroblast of posterior adult midgut epithelium | conditional phenotype, enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

NOT Enhanced by

Statement

Reference

Scer\GAL4^NP5130, mei-41^KK101792 has enteroblast of posterior adult midgut epithelium phenotype, non-enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Scer\GAL4^NP5130, mei-41^KK101792 has adult midgut epithelium phenotype, non-enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Scer\GAL4^NP5130, mei-41^KK101792 has intestinal stem cell of posterior adult midgut epithelium phenotype, non-enhanceable by Scer\GAL4^NP5130/tefu^GD11950

(Park et al., 2015)

Enhancer of

Statement

Reference

mei-41^KK101792, Scer\GAL4^en.PU is an enhancer of wing disc posterior compartment | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

mei-41^KK101792/Scer\GAL4^NP5130 is an enhancer of intestinal stem cell of posterior adult midgut epithelium | progressive phenotype of Scer\GAL4^NP5130, tefu^GD11950

(Park et al., 2015)

mei-41^KK101792/Scer\GAL4^NP5130 is an enhancer of enteroblast of posterior adult midgut epithelium | progressive phenotype of Scer\GAL4^NP5130, tefu^GD11950

(Park et al., 2015)

Suppressor of

Statement

Reference

mei-41^KK101792, Scer\GAL4^nub.PU is a suppressor | partially of wing phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

mei-41^KK101792, Scer\GAL4^nub.PU is a suppressor of wing disc | third instar larval stage phenotype of His1^NIG.31617R, Scer\GAL4^nub.PU

(Bayona-Feliu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The extensive cell death in the pouch region of wing discs in third instar larvae as well as the small and deformed wings in adults expressing His1:CG31617^NIG.31617R under the control of Scer\GAL4^nub.PU are significantly suppressed by co-expression of mei-41^KK101792.

(Bayona-Feliu et al., 2017)

The adulthood-only co-expression of mei-41^KK101792 and tefu^GD11950 results in: a more severe increase in γ-radiation-induced DNA damage in adult midgut progenitor cells (esg-positive intestinal stem cells and enteroblasts) compared to either single expression condition; a decrease in life-span that is comparable to that induced by the expression of mei-41^KK101792 alone but more severe than that induced by the expression of tefu^GD11950 alone; a progressive disappearance of progenitor cells that is comparable to that induced by the expression of mei-41^KK101792 alone but more severe than that induced by the expression of tefu^GD11950 alone; cell shape changes in intestinal progenitors comparable to those induced by the expression of mei-41^KK101792 alone; a decreased cell density in the adult midgut that is comparable to that induced by the expression of mei-41^KK101792 alone; decreases in intestinal stem cell number and DNA replication that are comparable to those induced by the expression of mei-41^KK101792 alone.

(Park et al., 2015)

Xenogenetic Interactions

Statement

Reference

The co-expression of mei-41^KK101792 enhances the ionizing irradiation-induced enlarged wing disc posterior compartment observed in individuals expressing BacA\p35^UAS.cHa under the control of Scer\GAL4^en.PU

(Dekanty et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103624

P{KK101792}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mei-41^KK101792

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close