FB2024_04 , released June 25, 2024
Allele: Dmel\Hsc70-4+t14
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General Information
Symbol
Dmel\Hsc70-4+t14
Species
D. melanogaster
Name
FlyBase ID
FBal0105151
Feature type
allele
Associated gene
Dmel\Hsc70-4
Associated Insertion(s)
Carried in Construct
P{Hsc70-4.14}
Also Known As
P[hsc4]
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Hing et al., 1999)
wild_type
(Hing et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Hing et al., 1999)
wild_type
(Hing et al., 1999)
Mutagen
in vitro construct
(Hing et al., 1999)
Progenitor genotype
Carried in construct
P{Hsc70-4.14}
Cytology
Description

Included within a 14kb fragment that encompasses the Hsc70-4 open reading frame together with 5' regulator sequences and 4kb downstream from the stop codon.

(Hing et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsc70-4
Encoded product / tool
Hsc70-4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:15,240,689..15,254,688 [+]
Comment:

A 14 kb genomic DNA fragment spanning from around position -2,000 to +12,000 rescues the recessive lethality of Hsc70-4[3550] mutant and the loss of synaptic transmission in homozygous Hsc70-4[Delta19] mutants. Position of mutation on reference sequence inferred by FlyBase curator.

(Bronk et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  ataxia telangiectasia
      CEA with tefuΔ356
      (Oikemus et al., 2004, Song et al., 2004)
      CEA with tefuΔ11
      (Song et al., 2004)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of visible | dominant | homeotic phenotype of Pc3

      (Mollaaghababa et al., 2001)
      Other
      Statement
      Reference

      Hsc70-4+t14/Hsc70-4[+], ph-p410 has viable phenotype

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14, ph-p410 has viable phenotype

      (Mollaaghababa et al., 2001)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of sex comb | ectopic phenotype of ph-p410

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of abdominal tergite 4 | male phenotype of Pc3

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of abdominal tergite 6 phenotype of Pc3

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 4 phenotype of Pc3

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 5 | ectopic phenotype of Pc3

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 6 phenotype of Pc3

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 7 | ectopic phenotype of Pc3

      (Mollaaghababa et al., 2001)

      Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of sex comb | ectopic phenotype of Pc3

      (Mollaaghababa et al., 2001)
      Suppressor of
      Statement
      Reference

      Hsc70-4+t14 is a suppressor of eye phenotype of Hsc70-4e19/Hsc70-4[+], mTorey.Tag:FLAG

      (Hennig et al., 2006)

      Hsc70-4+t14 is a suppressor of eye phenotype of Hsc70-4e3/Hsc70-4[+], mTorey.Tag:FLAG

      (Hennig et al., 2006)

      Hsc70-4+t14/Hsc70-4[+] is a suppressor of adult abdominal segment 5 phenotype of trxB11

      (Mollaaghababa et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Hsc70-4+t14 rescues Hsc70-4e3

      (Hennig et al., 2006)

      Hsc70-4+t14 rescues Hsc70-4e19

      (Hennig et al., 2006)

      Hsc70-4+t14 rescues Hsc70-4Δ19

      (Bronk et al., 2001)

      Hsc70-4+t14 rescues Hsc70-4195

      (Arbeitman and Hogness, 2000)

      Hsc70-4+t14 rescues Hsc70-4195

      (Hing et al., 1999)
      Comments

      The addition of Hsc70-4+t14 rescues the loss of synaptic transmission in Hsc70-4Δ19 mutants.

      (Bronk et al., 2001)

      Suppresses the dominant enhancement of EcR alleles by Hsc70-4195.

      (Arbeitman and Hogness, 2000)

      Restores the rough eye and slit bristle phenotype to Nspl-1, Hsc70-4195 double mutants. Restores viability to dx24, Hsc70-4195 double mutants.

      (Hing et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsc70-4+t14
      Name Synonyms
      Secondary FlyBase IDs
        References (8)