FB2024_04 , released June 25, 2024
Allele: Dmel\rad50EP1
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General Information
Symbol
Dmel\rad50EP1
Species
D. melanogaster
Name
FlyBase ID
FBal0134027
Feature type
allele
Associated gene
Dmel\rad50
Associated Insertion(s)
P{EP}rad50EP1
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ciapponi et al., 2004)
Mutagen
P-element activity
(Gorski and Eeken, 2002.3.21)
Delta2-3 transposase
(Gorski et al., 2004)
Progenitor genotype
P{EP}mRpS29EP2600
(Gorski et al., 2004, Gorski and Eeken, 2002.3.21)
Associated Insertion(s)
P{EP}rad50EP1
Cytology
Description

P{EP} insertion into the third exon of rad50, at position +1629 relative to the transcription start site.

(Gorski et al., 2004)

Insertion of P{EP} into the third exon of rad50.

(Gorski and Eeken, 2002.3.21)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPTR406W.UAS
      (Tuxworth et al., 2019)
      ameliorates  ataxia telangiectasia
      modeled by tefuRNAi.UAS
      (Rimkus et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      rad50Δ5.1/rad50EP1 adults have a scalloped wing margin. Mitotic neuroblasts from rad50EP1/Df(2R)X58-8 larval brains show a high frequency of telomere fusions and chromosome breaks. Single telomeric associations (in which a single telomere fuses with either its sister telomere or a single non-sister telomere) and double telomere associations are seen. Metaphases with rearranged chromosomes and hyperploid/polyploid cells are seen. Chromosome breaks involving either one or both sister chromatids are seen.

      (Ciapponi et al., 2004)

      Early embryogenesis and larval development appears normal.

      (Gorski and Eeken, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      rad50[+]/rad50EP1 is a suppressor of eye phenotype of Scer\GAL4GMR.PU, tefuRNAi.UAS

      (Rimkus et al., 2008)

      rad50[+]/rad50EP1 is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4GMR.PU, tefuRNAi.UAS

      (Rimkus et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rad50EP1/+ suppresses the rough-eye phenotype and increases the number of normal photoreceptors per ommatidium in flies expressing tefudsRNA.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Rimkus et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      rad50EP1 is rescued by rad50+tCa

      (Ciapponi et al., 2004)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dmrad50EP1
      (Gorski and Eeken, 2002)
      RAD50EP1
      (Rimkus et al., 2008)
      Rad50EP1
      (Gorski et al., 2004)
      rad50EP1
      (Li et al., 2021, Landmann et al., 2020, Tuxworth et al., 2019, Kurzhals et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)