HOAP, anon1G5, HP1/ORC-associated protein, p55, anon fe 1G5
poorly conserved component of the telomere capping complex - prevents end fusion by maintaining a chromatin state that is independent of the underlying DNA sequence
Please see the JBrowse view of Dmel\cav for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.39
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Component of the HipHop-HOAP telomere capping complex, composed of at least HipHop and cav/HOAP, and may include Su(var)205/HP1; HipHop and cav/HOAP, but not Su(var)205, are interdependent for their protein stability (PubMed:20057353). Interacts with HipHop (via N-terminus) (PubMed:20057353). Interacts (via C-terminus) with Su(var)205/HP1 dimer (via hinge and chromoshadow domain) and Orc1; possibly interacts with other components of the origin recognition complex (ORC) (PubMed:11408576, PubMed:12826664, PubMed:19181850). Each molecule of cav/HOAP interacts with 2 molecules of Su(var)205/HP1 (PubMed:12826664). The HipHop-HOAP complex recruits the MTV complex, consisting of moi/modigliani, tea and ver/verrocchio, to telomeres, forming the terminin telomere-capping complex (PubMed:19181850, PubMed:20679394). Interacts with moi/modigliani; the interaction is direct (PubMed:19181850). Interacts with ver/verrochio; the interaction is direct (PubMed:20679394). Interacts with HP6, which is also part of the terminin complex (PubMed:19190990). Interacts (via N-terminus) with peo/pendolino (via N-terminus); the interaction is direct (PubMed:26110638).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cav using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\cav in JBrowse3-84
3-82.8
3-85.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
cav protein binds specific heterochromatin satellite DNA sequences in gel mobility shift assays.
Mutant larvae have increased frequencies of telomeric fusions in brain cells.
Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.
Source for merge of: cav Hoap
Source for identity of: anon- EST:fe1G5 CG6219
Source for identity of: Hoap CG6219
The gene is named "caravaggio", because the linear multicentric chromosomes that characterize the mutant phenotype resemble little trains; there is an Italian train named "Caravaggio" in memory of the famous painter.
Named "caravaggio" after an Italian train, as the multicentric chromosomes observed in mutants resemble little trains of chromosomes.