marbles, marb, kls
controls bidirectional transport of lipid droplets, nuclear migration and transport of secretory vesicles - regulates microtubule stability and integrin receptor localization during collective cell migration
Please see the JBrowse view of Dmel\klar for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.52
8.5, 8.0 (northern blot)
None of the polypeptides share 100% sequence identity.
Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins (By similarity). Interacts with kud (PubMed:28716842). Interacts with Msp300; this interaction allows the anchoring of Msp300 nuclear ring structure to the nuclear envelope (PubMed:22927463).
The KASH domain mediates localization to the nuclear membrane (PubMed:15579692). Msp300 and Klar KASH domains cooperate to mediate the connection between a nuclear ring structure of Msp300 and the plus ends of a unique astral microtubule (MT) network (PubMed:22927463).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\klar using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Expression pattern inferred from unspecified enhancer trap line.
Prior to and during invagination of the salivary gland placodes klar transcripts were elevated in the dorsal and posterior cells.
Epitope-tagged klar protein is perinuclear in developing photoreceptors.
JBrowse - Visual display of RNA-Seq signals
View Dmel\klar in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
KASH forms of klar function in egg-laying.
In embryos injected with dsRNA made from templates generated with primers directed against this gene impairs the epithelial clouding phase of lipid droplet transport towards the minus end of microtubules.
klar is required for nuclear attachment to the microtubule organizing centre.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
snmRNA:438 is derived from the 3' UTR of klar.
Area matching Drosophila EST AA696845 (inverted).
klar may associate with Dynein.
klar may have a direct mechanical role in nuclear migration.
E. Wieschaus's laboratory has shown that marb is allelic to a previously identified locus named klar.
klar facilitates changes in force during lipid droplet transport.
Source for merge of: klar marb
'klarsicht' is German for 'clear view'.
