Transmembrane protein - expressed in 'loser' cells to mediate win/lose decisions in cell competition by means of differentially expressed isoforms
Please see the JBrowse view of Dmel\fwe for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fwe using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: presynaptically localized
fwe exhibits an isoform-dependent expression pattern. fwe-PA (fweUbi) is expressed ubiquitiously in the wing disc. In the pupal retina, at 44 hours APF, fwe-PA is expressed broadly, including in the neuronal layer. fwe-PC (fweLose-A) is expressed in all retinal neurons, while fwe-PB (fweLoseB) is expressed in ommatidia at the periphery of the retina, where photoreceptor neurons are undergoing programmed cell death.
JBrowse - Visual display of RNA-Seq signals
View Dmel\fwe in JBrowse3-43
3-37.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal
flower mutants display normal exocytosis but impaired endocytosis.
Area matching Drosophila ESTS AA441468 and AA142226 (inverted). Sequence similarity to C. elegans protein Z66496.
Source for merge of: flower CG6151
Source for merge of: CG6151 anon-WO0118547.242
Source for merge of CG6151 anon-WO0118547.242 was sequence comparison ( date:051113 ).
Source for identity of: fwe flower
This gene is called 'flower' due to the mutant phenotype where numerous extra synaptic boutons are generated, often in small clusters that are 'flowery in nature'.