TnI, hdp, troponin I, heldup, TpnI
cytoskeletal protein - along with Tropomyosin regulates muscle contraction - required to maintain nuclear integrity and apico-basal polarity during early embryogenesis - required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle
Please see the JBrowse view of Dmel\wupA for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
1.4, 1.2, 1.0 (northern blot)
1.3, 1.2, 1.1 (northern blot)
269, 208 (aa); 28.8, 24.5 (kD predicted)
208 (aa)
Binds to actin and tropomyosin.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wupA using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reference states 12 hr AEL
JBrowse - Visual display of RNA-Seq signals
View Dmel\wupA in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Haploinsufficient locus.
wupA transheterozygotes show transvection, evidenced by normal wing position in adults.
Mutation within a 4kb region of mostly non-coding sequences in wupA (the 'dominant lethal' domain of 16F) results in a dominant lethal phenotype due to the inactivation of the wupA, l(1)16Fe and l(1)16Fm genes. This 'dominant lethal' domain probably represents a long-range cis-regulatory region. In direction of increasing cytology: l(1)16Fo? l(1)16Fp? l(1)16Fq? mnb? l(1)16Fa? l(1)16Fb? l(1)16Fc? Sh? anon-16Fc? l(1)16Fh? anon-16Fd? scu? anon-16Fe? Taf8? anon-16Ff? wupA? l(1)16Fe? l(1)16Fm? l(1)16Fk? l(1)16Fn? ari-1? Frq1?
Variation of a microsatellite within the wupA locus has been studied in North American populations of D.melanogaster.
A splicing defect in the wupA gene causes abnormal development of flight muscles.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
Source for merge of: wupA fliH
